Abstract: Compounds of general formula (I): wherein R1, R2, R3, R4, R5a, R5b X1, X2, Z and Y are as defined herein are positive modulators of the calcium-activated chloride channel (CaCC), TMEM16A. The compounds are useful for treating diseases and conditions affected by modulation of TMEM16A, particularly respiratory diseases and conditions.

Abstract: An impactor mechanism for virtual or telepresence surgery comprises a base. An impactor shaft has a first end and a second end, a handle portion being provided at the second end. A rotational joint(s) is between the first end of the impactor shaft and the base, the joint providing two or more rotational degrees of freedom to the impactor shaft. Sensors are in the impactor mechanism for measuring an orientation of the impactor shaft relative to the base, and for measuring at least an impact force on the impactor shaft, for use in virtual surgery.

Abstract: The invention relates to compounds of general formula (I): wherein R1, R2, R3, R10 and X? are as defined herein. The compounds are inhibitors of the epithelial sodium channel (ENaC) and are useful for the treatment or prevention respiratory diseases and conditions.

Abstract: The present invention discloses bis(pentahydroxyhexyl)amino substituted 2-{[(3-amino-pyrazin-2-yl)formamido]methyl}-1H-1,3-benzodiazol-3-ium derivatives of formula (I) as inhibitors of ENaC and are of use in the treatment of respiratory diseases and conditions, skin conditions or ocular conditions, wherein the respiratory disease or condition is e.g. cystic fibrosis, chronic obstructive pulmonary disease (COPD), chronic bronchitis, emphysema, bronchiectasis, including non-cystic fibrosis bronchiectasis, and asthma; the skin condition is e.g. psoriasis, atopic dermatitis and ichthyosis; and the ocular condition is e.g. dry eye disease.

Abstract: An electromagnetic energy transmitting device includes a processing unit, a light-detecting sensor coupled to the processing unit, and a high-flux electromagnetic energy transmitter. An electromagnetic energy receiver arranged to convert received light into electricity. A first fiber-based conduit couples the high-flux electromagnetic energy transmitter to the electromagnetic energy receiver. The first fiber-based conduit is arranged to pass high-flux light from the high-flux electromagnetic energy transmitter to the electromagnetic energy receiver. A second fiber-based conduit couples the electromagnetic energy receiver to the light-detecting sensor. The second fiber-based conduit is arranged to pass at least some light from the electromagnetic energy receiver to the light-detecting sensor, wherein the processing unit is arranged to control an output of the high-flux light from the high-flux source based on a control signal from the light-detecting sensor.

Abstract: Compounds of general formula (I) wherein R1, R2, R3, R4, R5 and X are as defined herein are inhibitors of the epithelial sodium channel (ENaC) and are useful for the treatment or prevention respiratory diseases and conditions, skin conditions and ocular conditions.

Abstract: The invention relates to compounds of general formula (I): wherein R1, R2, R3, R10 and X? are as defined herein. The compounds are inhibitors of the epithelial sodium channel (ENaC) and are useful for the treatment or prevention respiratory diseases and conditions.

Abstract: A power beaming system delivers electric power in laser light from a first location to a remote second location. The laser light has a high energy intensity level defining a hazardous illumination area and a low energy intensity level defining a safe illumination area. The system includes guard circuitry emitter(s) and corresponding detector(s). The guard circuitry forms a detection area about the hazardous illumination area to detect objects in proximity to the hazardous illumination area. A controller directs the guard and power beam circuitry according to sequentially activated safety modes to operate at a low energy intensity level, to scan in a defined pattern, to adjust operation of the detector(s), and to set guard circuitry parameters based on a time value, an object detection value, or a change to the delivered electric power. An output coupled to the controller and power beam circuitry controllably permits or prevents operation at the high energy intensity level.

Abstract: An electromagnetic energy transmitting device includes a processing unit, a light-detecting sensor coupled to the processing unit, and a high-flux electromagnetic energy transmitter. An electromagnetic energy receiver arranged to convert received light into electricity. A first fiber-based conduit couples the high-flux electromagnetic energy transmitter to the electromagnetic energy receiver. The first fiber-based conduit is arranged to pass high-flux light from the high-flux electromagnetic energy transmitter to the electromagnetic energy receiver. A second fiber-based conduit couples the electromagnetic energy receiver to the light-detecting sensor. The second fiber-based conduit is arranged to pass at least some light from the electromagnetic energy receiver to the light-detecting sensor, wherein the processing unit is arranged to control an output of the high-flux light from the high-flux source based on a control signal from the light-detecting sensor.

Abstract: A laser safety device may include a light source and scanner capable of projecting a beam of electromagnetic radiation, a device for measuring distance, a control subsystem that may be interconnected with the light source and the device for measuring distance. The control subsystem may change characteristics of the beam of light to prevent people or objects from being harmed by the electromagnetic radiation based on measured distances from the light source to the people or objects.

Abstract: A game in which the moves players can make simulate both the symmetric and antisymmetric couplings of muscle pairs that accompany co-ordinated movement of the two sides of the human body, and in which each player's move comprises two components, one beneficial to the player and the other beneficial to the player(s) opponents (herein called chiralkines); a kit for playing the game; an electronic gaming device for use in playing the game; left- and right handed money and left- and right-handed property rights for use in a game or commerce; and apparatuses adapted for use with these.

Abstract: Technology, alternative to money, for enabling equitable trade between users. The technology embodies chiralkine money and chiralkine property rights created as vectors through chiralkine contracts made by a recorder that maintains an open register and a trading pair of two users.

Abstract: A game in which the moves players can make simulate both the symmetric and antisymmetric couplings of muscle pairs that accompany co-ordinated movement of the two sides of the human body, and in which each player's move comprises two components, one beneficial to the player and the other beneficial to the player(s) opponents (herein called chiralkines); a kit for playing the game; an electronic gaming device for use in playing the game; left- and right handed money and left- and right-handed property rights for use in a game or commerce; and apparatuses adapted for use with these.

Abstract: An illuminated cell phone case that includes a one piece bumper that surrounds a perimeter of a cell phone, illuminated indicia that is disposed on a back portion of the illuminating cell phone case and a LED, PCB and battery assembly. The illuminating cell phone case includes one or more programmable microprocessors that controls a plurality of LED lights, LCD Screens, LED Screens, a motion sensing chip, an audio detection sensor microphone, electronic microprocessor switches that activates electronic components powered by a battery that provides power to the illuminating cellphone case.

Abstract: A method of creating patent rights for a business entity in a drug candidate for clinical development, in which an expert in pharmaceutical science and an expert in pharmaceutical patent law collaborate in a risk-free environment to identify and protect drug candidates, and a kit useful in the method.

Abstract: A front projection screen assembly comprising, a rectangular sheet of a flexible screen material and a roller on which said flexible screen material may be wound and unwound, said flexible screen material defining a first plane in the unwound condition. The front projection screen assembly comprises top, bottom, left-hand and right-hand side frame members, framing said rectangular sheet of flexible screen material along respective top, bottom, left-hand and right-hand sides thereof. At least said side frame members comprise shape memory members.

Abstract: A self-contained sign, illuminated by laser or other source of substantially parallel beams, presenting intensely lighted and vividly colored displays, is programmable to display one or more user designed images through controlled deflection of projected beams. The sign comprises a backlit illuminated apparatus of low depth to display dimension ratio, astigmatically correcting distortion of the projected dot resulting from oblique projection angles, such correction occurring in the projected beam's light path prior to controlled beam deflection. Embodiments further normalize obliquely incident light by employing a transmissive refractive right angle structure. Distortion of a projected image is minimized by appropriate pre- or post-processing of display data. Embodiments enable animation of images and are adaptable to networked control.

Abstract: A boot drying apparatus utilizes a hollow plenum chamber having a lowermost open mouth portion for resting upon a hot air discharge grill disposed in the surface of a floor of a room. The chamber supports a number of upright extending tubes, each having a snout-like portion pointed in one direction. Each of the tubes has a plurality of openings disposed along the length thereof as well as an additional opening being located at the end of the snout. A rod is carried by such that the rod is slidably affixed to the tube having the uppermost end thereof extending outwardly from the tube and having the lowermost end thereof formed into a lowermost leg of an L-shaped portion of the rod to which a plate is affixed. The plate is slidably located adjacent an opening in the plenum chamber as are a plurality of curved plates located and affixed to the rod adjacent the vertical leg portion thereof within the length of the tube.