Patents by Inventor Alexander Heim

Alexander Heim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • O-linked pyrimidin-4-amine-based compounds, compositions comprising them, and methods of their use to treat cancer
    Patent number: 8093246
    Abstract: O-linked pyrimidin-4-amine-based compounds, pharmaceutical compositions comprising them, and methods of their use are described.
    Type: Grant
    Filed: December 12, 2007
    Date of Patent: January 10, 2012
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: David J. Augeri, Marianne Carlsen, Kenneth G. Carson, Qinghong Fu, Jason P. Healy, Alexander Heim-Riether, Theodore C. Jessop, Philip E. Keyes, Min Shen, James E. Tarver, Jerry A. Taylor, Xiaolian Xu
  • ALPHA-SUBSTITUTED N-SULFONYL GYLCINE AMIDES ANTAGONISTS OF CCR10, COMPOSITIONS CONTAINING THE SAME AND METHODS FOR USING THEM
    Publication number: 20110275612
    Abstract: Disclosed is a compound of formula (I). Wherein R1, R2Ar and Cy are as defined herein, or a pharmaceutically acceptable salt thereof. Also disclosed are pharmaceutical compositions of the compound of formula (I), methods of making the compounds of formula I, and methods of using the compounds of formula (I) to treat a disorder associated with activation of CCR10.
    Type: Application
    Filed: May 14, 2009
    Publication date: November 10, 2011
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Derek Cogan, Alexander Heim-Riether, Wang Mao, Craig Andrew Miller, Philip Dean Ramsden, Lana Louise Smith Keenan, Roger John Snow, Jiang-Ping Wu, Yu Yang
  • Heteroaryl Diamide Compounds Useful as MMP-13 Inhibitors
    Publication number: 20110275625
    Abstract: Disclosed are compounds and compositions of the formula (I) as described herein which are inhibitors of MMP-13. Also disclosed are methods of using and making compounds of the formula (I).
    Type: Application
    Filed: November 5, 2009
    Publication date: November 10, 2011
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Neil Alexander Farrow, Donghong Amy Gao, Alexander Heim-Riether, Shuang Liang, Sabine Schlyer, Lana Louise Smith Keenan, Steven John Taylor, Bernd Wellenzohn, Dieter Wiedenmayer, Zhaoming Xiong, Qiang Zhang
  • 2-SULFONYLAMINO-4-HETEROARYL BUTYRAMIDE ANTAGONISTS OF CCR10
    Publication number: 20110275800
    Abstract: This invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein R1, R2, R4. Ar and Het are as defined herein. The invention also relates to methods of using the compound of formula (I) to treat a diseases and disorders that are mediated or sustained through the activity of CCR10.
    Type: Application
    Filed: April 8, 2009
    Publication date: November 10, 2011
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Asitha Abeywardane, Derek Cogan, Younggi Choi, Donghong A. Gao, Daniel R. Goldberg, Alexander Heim-Riether, Craig Andrew Miller, Philip Dean Ramsden, Lana Louise Smith Keenan, Roger John Snow, Yang Yu
  • Heteroaryl Substituted Indole Compounds Useful as MMP-13 Inhibitors
    Publication number: 20110275631
    Abstract: Disclosed are compounds and compositions of the formula I as described herein which are inhibitors of MMP-13. Also disclosed are methods of using and making compounds of the formula I.
    Type: Application
    Filed: October 13, 2009
    Publication date: November 10, 2011
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Asitha Abeywardane, Bennett Farmer, II, Neil Alexander Farrow, Donghong Amy Gao, Alexander Heim-Riether, Lana Louise Smith Keenan, Ingo Andreas Mugge, Steven John Taylor, Zhaoming Xiong, Yang Yu, Qiang Zhang
  • Fused Heteroaryl Diamide Compounds Useful as MMP-13 Inhibitors
    Publication number: 20110269668
    Abstract: Disclosed are compounds and compositions of the formula I as described herein which are inhibitors of MMP-13. Also disclosed are methods of using and making compounds of the formula I.
    Type: Application
    Filed: October 13, 2009
    Publication date: November 3, 2011
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Alexander Heim-Riether, Shuang Liang, Sabine Schlyer
  • DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZO[1,2-alpha]IMIDAZOLE-3-CARBOXYLIC ACID AMIDES
    Publication number: 20110224188
    Abstract: Derivatives of 6,7-dihydro-5H-imidazo[1,2-?]imidazole-3-carboxylic acid amide exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the treatment of inflammatory disease.
    Type: Application
    Filed: November 20, 2008
    Publication date: September 15, 2011
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Antonio Jose del Moral Barbosa, Joerg Martin Benzien, Steven Richard Brunette, Zhidong Chen, Derek Cogan, Donghong A. Gao, Alexander Heim-Riether, Joshua Courtney Horan, Jennifer A. Kowalski, Michael David Lawlor, Rene Marc Lemieux, Weimin Liu, Bryan Mckibben, Craig Andrew Miller, Neil Moss, Matt Aaron Tschantz, Zhaoming Xiong, Hui Yu, Yang Yu
  • CCR10 ANTAGONISTS
    Publication number: 20110039851
    Abstract: The invention relates to a compound of formula (I): or a tautomer thereof or a pharmaceutically acceptable salt thereof, wherein R1 to R11, W, X, Y, Z, and n are as defined herein. The invention also relates to methods of using the compounds of formula (I) and compositions thereof to treat various diseases and disorders in a patient. The invention also relates to processes for preparing the compounds of formula (I) and intermediates useful in these processes.
    Type: Application
    Filed: October 14, 2008
    Publication date: February 17, 2011
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Kaka Dey, Donghong Amy Gao, Daniel R. Goldberg, Alexander Heim-Riether, John Edward Mangette, Ingo Andreas Mugge, Roger John Snow, Alan David Swinamer, Jiang-Ping Wu, Zhaoming Xiong, Yu Yang
  • Undulating washer or wave-shaped spring with a defined progressive characteristic spring rate
    Patent number: 7465138
    Abstract: An axially acting undulating washer or wave-shaped spring consisting of a closed annular member which comprises a central X-axis and which is periodically wave-shaped across the circumference, wherein a wave line extends so as to monotonically rise or fall between a plurality of identical minima and identical maxima and wherein in the minima and maximum of the wave line there are formed contact points of the annular member relative to axis-normal contact faces, wherein, starting from each minimum and maximum, the annular member, on both sides, i.e. in each circumferential direction, comprises at least two wave line portions which directly adjoin one another and which, with an increasing axial load, are individually flattened and made to contact and contact faces one after the other.
    Type: Grant
    Filed: April 15, 2005
    Date of Patent: December 16, 2008
    Assignee: Muhr und Bender KG
    Inventors: Alexander Heim, Andreas Rinsdorf
  • 4-AMINO-1H-PYRIMIDIN-2-ONE BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM AND METHODS OF THEIR USE
    Publication number: 20080182847
    Abstract: 4-Amino-1H-pyrimidin-2-one-based compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of various diseases and disorders are disclosed.
    Type: Application
    Filed: December 12, 2007
    Publication date: July 31, 2008
    Inventors: David J. Augeri, Marianne Carlsen, Kenneth G. Carson, Qinghong Fu, Alexander Heim-Riether, Theodore C. Jessop, James E. Tarver, Jerry A. Taylor
  • O-LINKED PYRIMIDIN-4-AMINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE TO TREAT CANCER
    Publication number: 20080146571
    Abstract: O-linked pyrimidin-4-amine-based compounds, pharmaceutical compositions comprising them, and methods of their use are described.
    Type: Application
    Filed: December 12, 2007
    Publication date: June 19, 2008
    Inventors: David J. Augeri, Marianne Carlsen, Kenneth G. Carson, Qinghong Fu, Jason P. Healy, Alexander Heim-Riether, Theodore C. Jessop, Philip E. Keyes, Min Shen, James E. Tarver, Jerry A. Taylor, Xiaolian Xu
  • Methods for synthesizing imidazotriazinones
    Publication number: 20060264624
    Abstract: Methods of synthesizing imidazotriazinones, such as vardenafil, and compositions useful for the same are disclosed.
    Type: Application
    Filed: May 17, 2006
    Publication date: November 23, 2006
    Inventors: Alexander Heim-Riether, David Rotella
  • Ondular washer or wave-shaped spring with a defined progressive characteristic spring rate
    Publication number: 20050271497
    Abstract: An axially acting ondular washer or wave-shaped spring consisting of a closed annular member which comprises a central X-axis and which is periodically wave-shaped across the circumference, wherein a wave line extends so as to monotonically rise or fall between a plurality of identical minima and identical maxima and wherein in the minima and maximum of the wave line there are formed contact points of the annular member relative to axis-normal contact faces, wherein, starting from each minimum and maximum, the annular member, on both sides, i.e. in each circumferential direction, comprises at least two wave line portions which directly adjoin one another and which, with an increasing axial load, are individually flattened and made to contact and contact faces one after the other.
    Type: Application
    Filed: April 15, 2005
    Publication date: December 8, 2005
    Inventors: Alexander Heim, Andreas Rinsdorf