Patents by Inventor Alexander Henrik Baron van Asbeck

Alexander Henrik Baron van Asbeck has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR REDUCING RNA IMMUNOGENICITY AND RNA MOLECULES WITH DECREASED IMMUNOGENICITY
    Publication number: 20230295637
    Abstract: The present invention relates to a method for decreasing the immunogenicity of an RNA molecule and/or at least maintaining the translation efficacy thereof. The present invention further relates to an RNA molecule, which is modified as compared to a corresponding wildtype RNA molecule, wherein the exchange of codons results in the total cytidine content of the modified RNA molecule being at least 10% less than the total cytidine content of the corresponding RNA molecule transcribed from said wildtype DNA sequence. The present invention also relates to an RNA molecule, wherein the exchange of codons results in the total uridine content of the modified RNA molecule being at least 10% less than the total uridine content of the corresponding RNA molecule transcribed from said wild-type DNA sequence. Finally, the present invention relates to the use of an RNA molecule of this invention in genome editing.
    Type: Application
    Filed: April 30, 2021
    Publication date: September 21, 2023
    Applicant: RiboPro B.V.
    Inventors: Alexander Henrik BARON VAN ASBECK, Jürgen Wilhelmus Carolus DIEKER
  • Nanoparticle comprising a bio-resorbable polyester, a hydrophilic polymer and an acylated human lactoferrin-derived peptide
    Patent number: 11052053
    Abstract: A nanoparticle includes a core. The core includes a bio-resorbable polyester and a hydrophilic polymer. The hydrophilic polymer is a portion of the bio-resorbable polyester or a separate polymer. An acylated human lactoferrin-derived peptide is coated onto the core. The acylated human lactoferrin-derived peptide is a peptide with the amino acid sequence SEQ ID NO. 1: KCFQWQRNMRKVRGPPVSCIKR or an amino acid sequence, which does not differ by more than 8 amino acid positions from the sequence SEQ ID NO: 1. The N-terminus of the human lactoferrin-derived peptide is acylated with a C16-monoacyl group.
    Type: Grant
    Filed: April 24, 2019
    Date of Patent: July 6, 2021
    Assignee: Evonik Operations GmbH
    Inventors: Roland Brock, Rike Nabbefeld, Silko Grimm, Anne Benedikt, Andrea Engel, Alexander Henrik Baron van Asbeck, Jürgen Dieker
  • Nanoparticle comprising a bio-resorbable polyester, a hydrophilic polymer and an acylated human lactoferrin-derived peptide
    Publication number: 20210137847
    Abstract: A nanoparticle includes a core. The core includes a bio-resorbable polyester and a hydrophilic polymer. The hydrophilic polymer is a portion of the bio-resorbable polyester or a separate polymer. An acylated human lactoferrin-derived peptide is coated onto the core. The acylated human lactoferrin-derived peptide is a peptide with the amino acid sequence SEQ ID NO. 1: KCFQWQRNMRKVRGPPVSCIKR or an amino acid sequence, which does not differ by more than 8 amino acid positions from the sequence SEQ ID NO: 1. The N-terminus of the human lactoferrin-derived peptide is acylated with a C16-monoacyl group.
    Type: Application
    Filed: April 24, 2019
    Publication date: May 13, 2021
    Applicant: Evonik Operations GmbH
    Inventors: Roland Brock, Rike Nabbefeld, Silko Grimm, Anne Benedikt, Andrea Engel, Alexander Henrik Baron van Asbeck, Jürgen Dieker