Patents by Inventor Alexander J. Muller

Alexander J. Muller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS UTILIZING IDO1-DEPENDENT VASCULARIZING CELLS FOR THE TREATMENT OF PATHOLOGICAL CONDITIONS INVOLVING NEOVASCULARIZATION
    Publication number: 20240084002
    Abstract: Compositions and methods for treating a retinopathy or inhibiting pathologic neovascularization in a subject are provided herein. In one embodiment, the method includes ablating or inhibiting IDO-dependent vascularizing cells (IDVCs) in the eye of the subject. Various methods of inhibiting or ablating IDVCs are described, including inhibiting IDO1 and/or integrated response nodes.
    Type: Application
    Filed: December 7, 2021
    Publication date: March 14, 2024
    Applicants: LANKENAU INSTITUTE FOR MEDICAL RESEARCH, DUET THERAPEUTICS, INC.
    Inventors: Alexander J. Muller, Arpita Mondal, Souvik Dey, Simon Tomlinson, Lisa Laury-Kleintop
  • METHODS AND COMPOSITIONS FOR THE TREATMENT OF RETINOPATHY AND OTHER OCULAR DISEASES
    Publication number: 20230301967
    Abstract: Compositions and methods for the treatment of ocular diseases are disclosed. In accordance with one aspect of the instant invention, methods for treating, inhibiting (e.g., reducing), and/or preventing an ocular disease in a subject are provided. The methods comprise the administration of at least one inhibitor of the induction or activity of tryptophan degradation and/or of the downstream pathways that respond to this process. In a particular embodiment, the methods comprise the administration of an inhibitor of IDO1.
    Type: Application
    Filed: January 23, 2023
    Publication date: September 28, 2023
    Applicant: Lankenau Institute for Medical Research
    Inventors: Alexander J. Muller, Arturo Bravo-Nuevo, Arpita Mondal, Courtney Smith, Hollie E. Flick
  • Methods and compositions for the treatment of retinopathy and other ocular diseases
    Patent number: 11564907
    Abstract: Compositions and methods for the treatment of ocular diseases are disclosed. In accordance with one aspect of the instant invention, methods for treating, inhibiting (e.g., reducing), and/or preventing an ocular disease in a subject are provided. The methods comprise the administration of at least one inhibitor of the induction or activity of tryptophan degradation and/or of the downstream pathways that respond to this process. In a particular embodiment, the methods comprise the administration of an inhibitor of IDO1.
    Type: Grant
    Filed: January 10, 2020
    Date of Patent: January 31, 2023
    Assignee: Lankenau Institute for Medical Research
    Inventors: Alexander J. Muller, Arturo Bravo-Nuevo, Arpita Mondal, Courtney Smith, Hollie E. Flick
  • Methods and compositions for the treatment of retinopathy and other ocular diseases
    Patent number: 11564906
    Abstract: Compositions and methods for the treatment of ocular diseases are disclosed. In accordance with one aspect of the instant invention, methods for treating, inhibiting (e.g., reducing), and/or preventing an ocular disease in a subject are provided. The methods comprise the administration of at least one inhibitor of the induction or activity of tryptophan degradation and/or of the downstream pathways that respond to this process. In a particular embodiment, the methods comprise the administration of an inhibitor of IDO1.
    Type: Grant
    Filed: January 10, 2020
    Date of Patent: January 31, 2023
    Assignee: Lankenau Institute for Medical Research
    Inventors: Alexander J. Muller, Arturo Bravo-Nuevo, Arpita Mondal, Courtney Smith, Hollie E. Flick
  • Methods and compositions for the treatment of retinopathy and other ocular diseases
    Patent number: 11376236
    Abstract: Compositions and methods for the treatment of ocular diseases are disclosed. In accordance with one aspect of the instant invention, methods for treating, inhibiting (e.g., reducing), and/or preventing an ocular disease in a subject are provided. The methods comprise the administration of at least one inhibitor of the induction or activity of tryptophan degradation and/or of the downstream pathways that respond to this process. In a particular embodiment, the methods comprise the administration of an inhibitor of IDO1.
    Type: Grant
    Filed: November 27, 2019
    Date of Patent: July 5, 2022
    Assignee: Lankenau Institute for Medical Research
    Inventors: Alexander J. Muller, Arturo Bravo-Nuevo, Arpita Mondal, Courtney Smith, Hollie E. Flick
  • METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER
    Publication number: 20200261414
    Abstract: Compositions and methods for the treatment of cancer are disclosed.
    Type: Application
    Filed: September 14, 2018
    Publication date: August 20, 2020
    Inventors: Alexander J. Muller, Arpita Mondal, Souvik Dey, George C. Prendergast
  • METHODS AND COMPOSITIONS FOR THE TREATMENT OF RETINOPATHY AND OTHER OCULAR DISEASES
    Publication number: 20200147046
    Abstract: Compositions and methods for the treatment of ocular diseases are disclosed. In accordance with one aspect of the instant invention, methods for treating, inhibiting (e.g., reducing), and/or preventing an ocular disease in a subject are provided. The methods comprise the administration of at least one inhibitor of the induction or activity of tryptophan degradation and/or of the downstream pathways that respond to this process. In a particular embodiment, the methods comprise the administration of an inhibitor of IDO1.
    Type: Application
    Filed: January 10, 2020
    Publication date: May 14, 2020
    Inventors: Alexander J. Muller, Arturo Bravo-Nuevo, Arpita Mondal, Courtney Smith, Hollie E. Flick
  • METHODS AND COMPOSITIONS FOR THE TREATMENT OF RETINOPATHY AND OTHER OCULAR DISEASES
    Publication number: 20200147045
    Abstract: Compositions and methods for the treatment of ocular diseases are disclosed. In accordance with one aspect of the instant invention, methods for treating, inhibiting (e.g., reducing), and/or preventing an ocular disease in a subject are provided. The methods comprise the administration of at least one inhibitor of the induction or activity of tryptophan degradation and/or of the downstream pathways that respond to this process. In a particular embodiment, the methods comprise the administration of an inhibitor of IDO1.
    Type: Application
    Filed: January 10, 2020
    Publication date: May 14, 2020
    Inventors: Alexander J. Muller, Arturo Bravo-Nuevo, Arpita Mondal, Courtney Smith, Hollie E. Flick
  • METHODS AND COMPOSITIONS FOR THE TREATMENT OF RETINOPATHY AND OTHER OCULAR DISEASES
    Publication number: 20200093793
    Abstract: Compositions and methods for the treatment of ocular diseases are disclosed. In accordance with one aspect of the instant invention, methods for treating, inhibiting (e.g., reducing), and/or preventing an ocular disease in a subject are provided. The methods comprise the administration of at least one inhibitor of the induction or activity of tryptophan degradation and/or of the downstream pathways that respond to this process. In a particular embodiment, the methods comprise the administration of an inhibitor of IDO1.
    Type: Application
    Filed: November 27, 2019
    Publication date: March 26, 2020
    Inventors: Alexander J. Muller, Arturo Bravo-Nuevo, Arpita Mondal, Courtney Smith, Hollie E. Flick
  • Methods and compositions for the treatment of retinopathy and other ocular diseases
    Patent number: 10525035
    Abstract: Compositions and methods for the treatment of ocular diseases are disclosed.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: January 7, 2020
    Assignee: LANKENAU INSTITUTE FOR MEDICAL RESEARCH
    Inventors: Alexander J. Muller, Arturo Bravo-Nuevo, Arpita Mondal, Courtney Smith, Hollie E. Flick
  • Methods and Compositions for the Treatment of Retinopathy and Other Ocular Diseases
    Publication number: 20170360751
    Abstract: Compositions and methods for the treatment of ocular diseases are disclosed.
    Type: Application
    Filed: December 18, 2015
    Publication date: December 21, 2017
    Inventors: Alexander J. Muller, Arturo Bravo-Nuevo, Arpita Mondal, Courtney Smith, Hollie E. Flick
  • IDO inhibitors and methods of use
    Patent number: 8476454
    Abstract: Compounds, compositions and methods for the treatment of malignancy are disclosed.
    Type: Grant
    Filed: April 13, 2010
    Date of Patent: July 2, 2013
    Assignee: Lankenau Institute for Medical Research
    Inventors: George C. Prendergast, Alexander J. Muller, James B. Duhadaway, William Malachowski
  • IDO inhibitors and methods of use thereof
    Patent number: 8389568
    Abstract: Novel indoleamine 2,3-dioxygenase (IDO) inhibitors, compositions comprising the same, and methods of use thereof are disclosed.
    Type: Grant
    Filed: March 14, 2008
    Date of Patent: March 5, 2013
    Assignee: Lankenau Institute for Medical Research
    Inventors: George C. Prendergast, William P. Malachowski, Alexander J. Muller
  • Methods for the treatment of cancer
    Patent number: 8383613
    Abstract: Compositions and methods for the treatment of malignancy and chronic viral infection are disclosed.
    Type: Grant
    Filed: July 20, 2011
    Date of Patent: February 26, 2013
    Assignee: Lankenau Institute for Medical Research
    Inventors: George C. Prendergast, Alexander J. Muller, James B. DuHadaway, William Malachowski
  • Novel Methods for the Treatment of Cancer
    Publication number: 20110311648
    Abstract: Compositions and methods for the treatment of malignancy and chronic viral infection are disclosed.
    Type: Application
    Filed: July 20, 2011
    Publication date: December 22, 2011
    Inventors: George C. Prendergast, Alexander J. Muller, James B. DuHadaway, William Malachowski
  • Methods for the treatment of cancer
    Patent number: 8008281
    Abstract: Compositions and methods for the treatment of malignancy and chronic viral infection are disclosed.
    Type: Grant
    Filed: February 20, 2004
    Date of Patent: August 30, 2011
    Assignee: Lankenau Institute for Medical Research
    Inventors: George C. Prendergast, Alexander J. Muller, James B. DuHadaway, William Malachowski
  • NOVEL IDO INHIBITORS AND METHODS OF USE
    Publication number: 20100233166
    Abstract: Compounds, compositions and methods for the treatment of malignancy are disclosed.
    Type: Application
    Filed: April 13, 2010
    Publication date: September 16, 2010
    Inventors: George C. Prendergast, Alexander J. Muller, James B. Duhadaway, William Malachowski
  • Novel IDO Inhibitors and Methods of Use Thereof
    Publication number: 20100166881
    Abstract: Novel indoleamine 2,3-dioxygenase (IDO) inhibitors, compositions comprising the same, and methods of use thereof are disclosed.
    Type: Application
    Filed: March 11, 2010
    Publication date: July 1, 2010
    Inventors: George C. Prendergast, William P. Malachowski, Alexander J. Muller, James B. DuHadaway
  • IDO inhibitors and methods of use
    Patent number: 7714139
    Abstract: Compounds, compositions and methods for the treatment of malignancy are disclosed.
    Type: Grant
    Filed: February 20, 2004
    Date of Patent: May 11, 2010
    Assignee: Lankenau Institute for Medcial Research
    Inventors: George C. Prendergast, Alexander J. Muller, James B. Duhadaway, William Malachowski
  • IDO inhibitors and methods of use thereof
    Patent number: 7705022
    Abstract: Novel indoleamine 2,3-dioxygenase (IDO) inhibitors, compositions comprising the same, and methods of use thereof are disclosed.
    Type: Grant
    Filed: October 27, 2006
    Date of Patent: April 27, 2010
    Assignee: Lankenau Institute for Medical Research
    Inventors: George C. Prendergast, William P. Malachowski, Alexander J. Muller, James B. DuHadaway