Abstract: An embodiment of the present disclosure provides a footwear including a sole and at least one upper. The sole includes: a sole body; and at least one first mating connector located on the sole body. The at least one upper includes: an upper body; and at least one first mating connector located on the upper body. Each of the at least one first mating connector of the upper is configured to be detachably attached to one of the at least one first mating connector of the at least one sole.

Abstract: The application pertains to pharmaceutical combinations of orally administered paclitaxel and a P-gp inhibitor. The pharmaceutical combinations are suitable for the treatment of cancer in a subject and for reducing or preventing toxicity, hypersensitivity-type infusion reactions, and other negative outcomes resulting from or associated with intravenously administered paclitaxel (e.g., Taxol® or paclitaxel formulated with Cremophor®) therapy in a subject suffering from cancer.

Abstract: An artificial cave has various features that resemble speleothems (e.g., stalactites, stalagmites, etc.) found in real subterranean caves. Human users may pass through the artificial cave, with each user wearing a wearable transceiver that broadcasts a signal code unique to that user. Fixed transceivers throughout the cave can detect and identify any user who is sufficiently close to that fixed transceiver. Other components of the system collect user identification information from the fixed transceivers for any of several possible purposes (e.g., identifying which user was probably responsible for inappropriate interaction with a speleothem that is adjacent to a given fixed transceiver, where all of the various user of the cave are currently located in the cave, etc.). A count of users currently in the artificial cave passageway may be maintained and used for a number of purposes.

Abstract: An artificial cave has various features that resemble speleothems (e.g., stalactites, stalagmites, etc.) found in real subterranean caves. Human users may pass through the artificial cave, with each user wearing a wearable transceiver that broadcasts a signal code unique to that user. Fixed transceivers throughout the cave can detect and identify any user who is sufficiently close to that fixed transceiver. Other components of the system collect user identification information from the fixed transceivers for any of several possible purposes (e.g., identifying which user was probably responsible for inappropriate interaction with a speleothem that is adjacent to a given fixed transceiver, where all of the various user of the cave are currently located in the cave, etc.).

Abstract: The present invention relates to an improved [18F]labelled synthon composition, wherein the non-radioactive impurities in said composition have been found to be more straightforward to remove than with known compositions comprising said [18F]labelled synthon. The resultant purified [18F]label led synthon therefore can be used in the production of a positron emission tomography (PET) tracer having improved properties for in vivo imaging. The invention also includes methods of imaging and/or diagnosis using the radiopharmaceutical compositions described.

Abstract: The invention relates to methods for processing [18F]-fluoride target water using a solid-support bound Cryptand of formula (I) and to apparatus for performing such methods. The resultant [18F]-fluoride is useful for preparation of radiopharmaceuticals by nucleophilic fluorination, specifically for use in Positron Emission Tomography (PET).

Abstract: The invention relates to methods for processing [18F]-fluoride target water using a solid-support bound Cryptand of formula (I) and to apparatus for performing such methods. The resultant [18F]-fluoride is useful for preparation of radiopharmaceuticals by nucleophilic fluorination, specifically for use in Positron Emission Tomography (PET).

Abstract: The present invention provides a method to obtain radiofluorinated compounds useful for in vivo imaging GABAA receptors. The method of the invention is high-yielding and may conveniently be carried out on an automated synthesizer such as Fastlab™. A further aspect of the invention is a cassette suitable for carrying out the automated method of synthesis of the invention. Novel precursor compounds useful in the method of the invention are also provided, as are a number of novel compounds obtained by the method of the invention.

Abstract: In view of the needs of the art, the present invention provides a reaction vessel having two distinct compartments, for separating solid-supported reagents. The present invention also provides a method to perform two step radiochemistry procedures in one reactor in a clean and 10 efficient manner. An example of the chemistry that could benefit from this approach is ‘click’ radiochemistry. The present invention provides a method to form the synthon, and react it with an alkyne without the need to perform a purification step.

Abstract: A stacked reactor vessel provides two separate reaction vessel compartments for performing chemical reactions and is particularly suited to multi-step chemical reactions and for incorporation into a cassette for automated operation.

Abstract: A connector cap for a reagent bottle which can be pre-attached to a fully assembled synthesis cassette allows greater control in the assembly of the cassette and simpler operation for the end user. The connector cap may be incorporated onto reagent bottle or on vials to be used with automated synthesis cassettes.

Abstract: A method and system of synchronizing accounting objects between a client and server are provided. In accordance with one embodiment, there is provided a method for use on a server of synchronizing data between a client accounting database on a client computer and the server accounting database on the server, the client computer and server being connected over a communication network by a persistent connection, each of the client accounting database and server accounting database comprising a number of tables, wherein accounting objects are defined by a group of one or more related records in one or more tables in the client accounting database and server accounting database.

Abstract: An obstacle course has the appearance of a natural cave environment. The course may include a plurality of interconnected, hollow, three-dimensional shapes through which human users can pass. The shapes may be modular to allow various different configurations of the course. The shapes may contain models of cave formations (speleothems), with which the users are expected to avoid contact and close proximity. Electronic sensing may be provided for monitoring any contact and proximity of the users to the speleothems, and additional electronic circuitry may be provided to present feedback to the users regarding their performance in the course.

Abstract: System and method for monitoring a synthesis process in a synthesizer to provide reduced quality control efforts and facilitate quality by design. The system and method perform by detecting a synthesizer parameter value for one or more synthesizer parameters of a radiopharmaceutical synthesis process in a radiopharmaceutical synthesizer, and comparing the synthesizer parameter value of each of the synthesizer parameters to a corresponding reference synthesizer value range. The radiopharmaceutical synthesis process is either continued, aborted, or interrupted based on a comparison result.

Abstract: The present invention provides a method to obtain radiofluorinated compounds useful for in vivo imaging GABAA receptors. The method of the invention is high-yielding and may conveniently be carried out on an automated synthesizer such as Fastlab™. A further aspect of the invention is a cassette suitable for carrying out the automated method of synthesis of the invention. Novel precursor compounds useful in the method of the invention are also provided, as are a number of novel compounds obtained by the method of the invention.

Abstract: The present invention provides novel compounds which may be used as in vivo imaging agents. The compounds of the invention are useful in a method to image the expression of P2X7 receptors in a subject, as a means to facilitate the diagnosis of a range of disease states.

Abstract: The present invention relates to imaging agents suitable for in vivo optical imaging, which comprise conjugates of dihydrocarbazolium dyes with biological targeting moieties, such as peptides. Also disclosed are pharmaceutical compositions and kits, as well as in vivo imaging methods. The dihydrocarbazolium dyes are functionalised with water solubilising groups and have functional groups which facilitate conjugation to biological targeting moieties.

Abstract: A method and system of synchronizing accounting objects between a client and server are provided. In accordance with one embodiment, there is provided a method for use on a server of synchronizing data between a client accounting database on a client computer and the server accounting database on the server, the client computer and server being connected over a communication network by a persistent connection, each of the client accounting database and server accounting database comprising a number of tables, wherein accounting objects are defined by a group of one or more related records in one or more tables in the client accounting database and server accounting database.

Abstract: The invention relates to a compound of formula (I): wherein P1, P2, P3, and P4 are each independently hydrogen or a protecting group; and n is an integer of from 2 to 20 and to the use of such compounds for the synthesis of 18F-FDG.

Abstract: The invention relates to methods for processing [18F]-fluoride target water using a solid-support bound Cryptand of formula (I) and to apparatus for performing such methods. The resultant [18F]-fluoride is useful for preparation of radiopharmaceuticals by nucleophilic fluorination, specifically for use in Positron Emission Tomography (PET).