Patents by Inventor Alexander Jaeger

Alexander Jaeger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190365719
    Abstract: It has been established that exposure to cytotoxic doses of HSP90 inhibitor is broadly immunosuppressive, whereas continuous exposure to low-dosages of the same inhibitor exerts anti-tumor activity. The anti-tumor activity is mediated by the host immune system. Compositions and methods for continuous, low-dose exposure to HSP90 inhibitors in combination with one or more immunostimulatory agents for the treatment of cancer are described. Typically, the HSP90 inhibitor is administered in an amount that is between 1% and 20% of the clinically-determined maximum tolerate dose. The immunostimulatory agent can be administered simultaneously with the HSP90 inhibitor, or at some time before or after the HSP90 inhibitor. Compositions including a sub-toxic dose of HSP90 inhibitor in combination with an immunostimulatory agent in an amount effective to treat cancer are also provided.
    Type: Application
    Filed: June 3, 2019
    Publication date: December 5, 2019
    Inventors: Tyler Jacks, Alexander Jaeger, Sandro Santagata, Luke Whitesell, Susan Lindquist
  • Patent number: 9946959
    Abstract: In an example, high-dimensional data is projected to a multi-dimensional space to differentiate clusters of the high-dimensional data. A user selection of at least two of the clusters may be received and a plurality of dissimilar dimensions may be extracted from the at least two clusters. In addition, a user selected of a dissimilar dimension from the plurality of extracted dissimilar dimensions may be received. In response to receipt of the user selection of the dissimilar dimension from the plurality of dissimilar dimensions, a plurality of correlated dimensions to the dissimilar dimension may be determined. In addition, the plurality of dissimilar dimensions and the plurality of correlated dimensions may be displayed.
    Type: Grant
    Filed: April 30, 2014
    Date of Patent: April 17, 2018
    Assignee: ENTIT SOFTWARE LLC
    Inventors: Ming C. Hao, Wei-Nchih Lee, Alexander Jaeger, Nelson L. Chang, Daniel Keim
  • Publication number: 20170046597
    Abstract: In an example, high-dimensional data is projected to a multi-dimensional space to differentiate clusters of the high-dimensional data. A user selection of at least two of the clusters may be received and a plurality of dissimilar dimensions may be extracted from the at least two clusters. In addition, a user selected of a dissimilar dimension from the plurality of extracted dissimilar dimensions may be received. In response to receipt of the user selection of the dissimilar dimension from the plurality of dissimilar dimensions, a plurality of correlated dimensions to the dissimilar dimension may be determined. In addition, the plurality of dissimilar dimensions and the plurality of correlated dimensions may be displayed.
    Type: Application
    Filed: April 30, 2014
    Publication date: February 16, 2017
    Inventors: Ming C. Hao, Wei-Nchih Lee, Alexander Jaeger, Nelson L. Chang, Daniel Keim