Patents by Inventor Alexander James Mijalis
Alexander James Mijalis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230279045Abstract: Methods and systems for control of solid phase peptide synthesis are generally described. Control of solid phase peptide synthesis involves the use of feedback from one or more reactions and/or processes (e.g., reagent removal) taking place in the solid phase peptide synthesis system. In some embodiments, a detector may detect one or more fluids flowing across a detection zone of a solid phase peptide synthesis system and one or more signals may be generated corresponding to the fluid(s). For instance, an electromagnetic radiation detector positioned downstream of a reactor may detect a fluid exiting the reactor after a deprotection reactor and produce a signal(s). In some embodiments, based at least in part on information derived from the signal(s), a parameter of the system may be modulated prior to and/or during one or more subsequent reactions and/or processes taking place in the solid phase peptide synthesis system.Type: ApplicationFiled: December 20, 2022Publication date: September 7, 2023Applicant: Massachusetts Institute of TechnologyInventors: Dale Arlington Thomas, III, Alexander James Mijalis, Bradley L. Pentelute, Mark David Simon, Surin Mong
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Publication number: 20230174572Abstract: Methods and system for solid phase peptide synthesis are provided. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. New amino acid residues are added via a coupling reaction between an activated amino acid and an amino acid residue of the immobilized peptide. Amino acids may be activated using, e.g., a base and an activating agent. Certain inventive concepts, described herein, relate to methods and systems for the activation of amino acids. These systems and methods may allow for fewer side reactions and a higher yield compared to conventional activation techniques as well as the customization of the coupling reaction on a residue-by-residue basis without the need for costly and/or complex processes.Type: ApplicationFiled: May 18, 2022Publication date: June 8, 2023Applicant: Massachusetts Institute of TechnologyInventors: Dale Arlington Thomas, III, Alexander James Mijalis, Bradley L. Pentelute, Mark David Simon, Andrea Adamo, Patrick Louis Heider, Klavs F. Jensen
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Patent number: 11584776Abstract: Methods and systems for control of solid phase peptide synthesis are generally described. Control of solid phase peptide synthesis involves the use of feedback from one or more reactions and/or processes (e.g., reagent removal) taking place in the solid phase peptide synthesis system. In some embodiments, a detector may detect one or more fluids flowing across a detection zone of a solid phase peptide synthesis system and one or more signals may be generated corresponding to the fluid(s). For instance, an electromagnetic radiation detector positioned downstream of a reactor may detect a fluid exiting the reactor after a deprotection reactor and produce a signal(s). In some embodiments, based at least in part on information derived from the signal(s), a parameter of the system may be modulated prior to and/or during one or more subsequent reactions and/or processes taking place in the solid phase peptide synthesis system.Type: GrantFiled: May 15, 2020Date of Patent: February 21, 2023Assignee: Massachusetts Institute of TechnologyInventors: Dale Arlington Thomas, III, Alexander James Mijalis, Bradley L. Pentelute, Mark David Simon, Surin Mong
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Publication number: 20210188901Abstract: Methods and system for solid phase peptide synthesis are provided. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. New amino acid residues are added via a coupling reaction between an activated amino acid and an amino acid residue of the immobilized peptide. Amino acids may be activated using, e.g., a base and an activating agent. Certain inventive concepts, described herein, relate to methods and systems for the activation of amino acids. These systems and methods may allow for fewer side reactions and a higher yield compared to conventional activation techniques as well as the customization of the coupling reaction on a residue-by-residue basis without the need for costly and/or complex processes.Type: ApplicationFiled: October 30, 2020Publication date: June 24, 2021Applicant: Massachusetts Institute of TechnologyInventors: Dale Arlington Thomas, III, Alexander James Mijalis, Bradley L. Pentelute, Mark David Simon, Andrea Adamo, Patrick Louis Heider, Klavs F. Jensen
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Publication number: 20210047365Abstract: Methods and systems for control of solid phase peptide synthesis are generally described. Control of solid phase peptide synthesis involves the use of feedback from one or more reactions and/or processes (e.g., reagent removal) taking place in the solid phase peptide synthesis system. In some embodiments, a detector may detect one or more fluids flowing across a detection zone of a solid phase peptide synthesis system and one or more signals may be generated corresponding to the fluid(s). For instance, an electromagnetic radiation detector positioned downstream of a reactor may detect a fluid exiting the reactor after a deprotection reactor and produce a signal(s). In some embodiments, based at least in part on information derived from the signal(s), a parameter of the system may be modulated prior to and/or during one or more subsequent reactions and/or processes taking place in the solid phase peptide synthesis system.Type: ApplicationFiled: May 15, 2020Publication date: February 18, 2021Applicant: Massachusetts Institute of TechnologyInventors: Dale Arlington Thomas, Alexander James Mijalis, Bradley L. Pentelute, Mark David Simon, Surin Mong
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Patent number: 10683325Abstract: Methods and systems for control of solid phase peptide synthesis are generally described. Control of solid phase peptide synthesis involves the use of feedback from one or more reactions and/or processes (e.g., reagent removal) taking place in the solid phase peptide synthesis system. In some embodiments, a detector may detect one or more fluids flowing across a detection zone of a solid phase peptide synthesis system and one or more signals may be generated corresponding to the fluid(s). For instance, an electromagnetic radiation detector positioned downstream of a reactor may detect a fluid exiting the reactor after a deprotection reactor and produce a signal(s). In some embodiments, based at least in part on information derived from the signal(s), a parameter of the system may be modulated prior to and/or during one or more subsequent reactions and/or processes taking place in the solid phase peptide synthesis system.Type: GrantFiled: September 16, 2016Date of Patent: June 16, 2020Assignee: Massachusetts Institute of TechnologyInventors: Dale Arlington Thomas, III, Alexander James Mijalis, Bradley L. Pentelute, Mark David Simon, Surin Mong
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Publication number: 20170081358Abstract: Methods and systems for control of solid phase peptide synthesis are generally described. Control of solid phase peptide synthesis involves the use of feedback from one or more reactions and/or processes (e.g., reagent removal) taking place in the solid phase peptide synthesis system. In some embodiments, a detector may detect one or more fluids flowing across a detection zone of a solid phase peptide synthesis system and one or more signals may be generated corresponding to the fluid(s). For instance, an electromagnetic radiation detector positioned downstream of a reactor may detect a fluid exiting the reactor after a deprotection reactor and produce a signal(s). In some embodiments, based at least in part on information derived from the signal(s), a parameter of the system may be modulated prior to and/or during one or more subsequent reactions and/or processes taking place in the solid phase peptide synthesis system.Type: ApplicationFiled: September 16, 2016Publication date: March 23, 2017Applicant: Massachusetts Institute of TechnologyInventors: Dale Arlington Thomas, III, Alexander James Mijalis, Bradley L. Pentelute, Mark David Simon, Surin Mong
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Publication number: 20170081359Abstract: Methods and system for solid phase peptide synthesis are provided. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. New amino acid residues are added via a coupling reaction between an activated amino acid and an amino acid residue of the immobilized peptide. Amino acids may be activated using, e.g., a base and an activating agent. Certain inventive concepts, described herein, relate to methods and systems for the activation of amino acids. These systems and methods may allow for fewer side reactions and a higher yield compared to conventional activation techniques as well as the customization of the coupling reaction on a residue-by-residue basis without the need for costly and/or complex processes.Type: ApplicationFiled: September 16, 2016Publication date: March 23, 2017Applicant: Massachusetts Institute of TechnologyInventors: Dale Arlington Thomas, III, Alexander James Mijalis, Bradley L. Pentelute, Mark David Simon, Andrea Adamo, Patrick Louis Heider, Klavs F. Jensen