Abstract: Provided herein are compounds of formula (II): or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein m, n, p, R1, R2, R3, L1, L2, L3, R4, X1, X2, X3, and X4 are as defined herein. Also provided are methods of preparing compounds of formula (II), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing. Also provided are methods of inhibiting APOL1 and methods of treating an APOL1-mediated disease, disorder, or condition in an individual.

Abstract: The present invention relates to the extraction of lithium from liquid resources such as natural and synthetic brines, leachate solutions from clays and minerals, and recycled products.

Abstract: The techniques herein are directed generally to a “zero-knowledge” data management network. Users are able to share verifiable proof of data and/or identity information, and businesses are able to request, consume, and act on the data—all without a data storage server or those businesses ever seeing or having access to the raw sensitive information (where server-stored data is viewable only by the intended recipients, which may even be selected after storage). In one embodiment, source data is encrypted with a source encryption key (e.g., source public key), with a rekeying key being an encrypting combination of a source decryption key (e.g., source private key) and a recipient's public key. Without being able to decrypt the data, the storage server can use the rekeying key to re-encrypt the source data with the recipient's public key, to then be decrypted only by the corresponding recipient using its private key, accordingly.

Abstract: Systems and methods are provided for asset utilization and trigger-based automation. A network management system may receive a receive a network management configuration that identifies a configuration of a set of assets to be allocated to a service. The network management system may generate an asset utilization dataset including a set of utilization values associated with the set of assets generated over a time. The asset utilization data set may be used to train a machine-learning model configured to generated predictions corresponding to a future utilization associated with the set of assets. The network management system may then execute the machine-learning model predict utilization of a first asset. Upon determining that the predicted utilization is greater than a threshold, the network management system may execute an action associated with the set of assets.

Abstract: An optical sensing module suitable for wearable devices, the optical sensing module comprising: a silicon or silicon nitride transmitter photonic integrated circuit (PIC), the transmitter PIC comprising: a plurality of lasers, each laser of the plurality of lasers operating at a wavelength that is different from the wavelength of the others; an optical manipulation region, the optical manipulation region comprising one or more of: an optical modulator, optical multiplexer (MUX); and additional optical manipulation elements; and one or more optical outputs for light originating from the plurality of lasers.

Abstract: A handheld vacuum cleaner includes a dirt separator. The dirt separator includes a chamber having an inlet through which dirt-laden fluid enters and an outlet through which cleansed fluid exits the chamber. A disc located at the outlet rotates about a rotational axis and comprises holes through which the cleansed fluid passes.

Abstract: In various embodiments, a medical device includes: a tissue sample-receiving surface; an electrode array that includes a first electrode and a second electrode that are positioned to contact a tissue sample disposed on the tissue sample-receiving surface; and an impedance bridge that is communicatively coupled to the electrode array.

Abstract: A rotor for an electric machine, including a laminated core with slots in which bottom bars and top bars are arranged to in an axial direction beyond the laminated core to form a winding overhang. A bottom bar of one slot is respectively connected to a top bar of another slot in the winding overhang and, in a plan view, bottom bars and top bars cross axially outside the laminated core at crossing points and gaps remain between the crossing points. A support device has a retaining body arranged radially inside the winding overhang and at least one clip having two legs and a crosspiece. The is connected to both the retaining body and to a top bar to radially support the top bar by the retaining body. To ensure a robust stabilization of the winding overhang the legs protrude through two gaps adjacent to different top bars.

Abstract: A cuff for an air delivery conduit includes a first end portion provided to a tube and a second end portion adapted to engage a tubular connector. The second end portion includes an annular bead for sealing and retention.

Abstract: The techniques herein are directed generally to a “zero-knowledge” data management network. Users are able to share verifiable proof of data and/or identity information, and businesses are able to request, consume, and act on the data—all without a data storage server or those businesses ever seeing or having access to the raw sensitive information (where server-stored data is viewable only by the intended recipients, which may even be selected after storage). In one embodiment, source data is encrypted with a source encryption key (e.g., source public key), with a rekeying key being an encrypting combination of a source decryption key (e.g., source private key) and a recipient's public key. Without being able to decrypt the data, the storage server can use the rekeying key to re-encrypt the source data with the recipient's public key, to then be decrypted only by the corresponding recipient using its private key, accordingly.

Abstract: A monitoring system that is configured to monitor a property is disclosed. The monitoring system includes a sensor that is configured to generate sensor data that indicates an attribute of the property; a floor sensor that is configured to generate floor sensor data that indicates an amount of pressure applied to a portion of a floor of the property; and a monitor control unit. The monitor control unit is configured to receive, from the sensor, the sensor data; receive, from the floor sensor, the floor sensor data; analyze the sensor data and the floor sensor data; and based on analyzing the sensor data and the floor sensor data, perform a monitoring system action.

Abstract: An autonomous vehicle includes one or more sensors for detecting an object in an environment surrounding the autonomous vehicle and a vehicle computing system comprising one or more processors receiving canonical route data associated with at least one canonical route, and controlling travel of the autonomous vehicle based on sensor data from the one or more sensors and the canonical route data associated with the at least one canonical route. The at least one canonical route comprises at least one roadway connected with another roadway in a plurality of roadways in a geographic location that satisfies at least one route optimization function derived based on trip data associated with one or more traversals of the plurality of roadways in a geographic location by one or more autonomous vehicles.

Abstract: A lubricating member for a hair removal device, in which the lubricating member includes a lubricating material, in which the lubricating material includes a polyglutamic acid (PGA) material. Also disclosed is a lubricating composition including: a matrix material and a lubricating material, in which the lubricating material includes a PGA material and the PGA includes at least 5% of the lubricating composition by weight. Also disclosed is a method of forming a corresponding lubricating member.

Abstract: Connectivity is enabled between a first and second isolated network using a virtual traffic hub that includes a decision master node responsible for determining a routing action for a packet received at the hub. At the hub, a determination is made that a particular domain name system (DNS) message being directed to a first resource in the first isolated network is to include an indication of a second resource in the second isolated network. The second resource is assigned a network address within a private address range of the second isolated network, which overlaps with a private address range being used in the first isolated network. The hub causes a transformed version of the network address to be included in the DNS message delivered to the first resource.

Abstract: The present invention relates to the extraction of lithium from liquid resources such as natural and synthetic brines, leachate solutions from clays and minerals, and recycled products.

Abstract: Systems and methods described herein facilitate biometric, health, and activity data aggregation and visualization in order to provide improved physical performance tracking and medical monitoring. In some examples, the system can providing real time access to healthcare providers during telehealth sessions. In some examples, the system can include infectious disease monitoring, enabling a healthcare provider to monitor and provide healthcare to a group of patients outside of a clinical setting.

Abstract: The present invention relates to a method of preparing a topical pharmaceutical composition, a pharmaceutical composition prepared by the method, a topical pharmaceutical composition, and to uses and methods involving the pharmaceutical composition. The pharmaceutical composition comprises at least one local anesthetic agent and a vasoconstrictive agent. The method of preparing the composition comprises stirring an aqueous liquid comprising at least one local anesthetic agent and a vasoconstrictive agent, wherein the stirring is performed substantially without forming a vortex and under an inert gas. The at least one local anesthetic agent may be lignocaine and tetracaine, and the vasoconstrictive agent may be adrenaline.

Abstract: The techniques herein are directed generally to a “zero-knowledge” data management network. Users are able to share verifiable proof of data and/or identity information, and businesses are able to request, consume, and act on the data—all without a data storage server or those businesses ever seeing or having access to the raw sensitive information (where server-stored data is viewable only by the intended recipients, which may even be selected after storage). In one embodiment, source data is encrypted with a source encryption key (e.g., source public key), with a rekeying key being an encrypting combination of a source decryption key (e.g., source private key) and a recipient's public key. Without being able to decrypt the data, the storage server can use the rekeying key to re-encrypt the source data with the recipient's public key, to then be decrypted only by the corresponding recipient using its private key, accordingly.

Abstract: A surgical robotic system includes at least one eye tracking system positioned detect the direction of at least one user's gaze. Input derived from the eye tracking system may be used to enter commands to the surgical robotic system depending on the directions of the gaze detected or other aspects of the gaze such as pupil dilation or speed of eye movement.