Patents by Inventor Alexander Karpeisky

Alexander Karpeisky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthetic ribonucleic acids with RNAse activity
    Patent number: 6528640
    Abstract: Novel nucleotide triphosphates, methods of synthesis and process of incorporating these nucleotide triphosphates into oligonucleotides, and isolation of novel nucleic acid catalysts (e.g., ribozymes) are disclosed. Also, described are the use of novel enzymatic nucleic acid molecules to inhibit HER2/neu/ErbB2 gene expression and their applications in human therapy.
    Type: Grant
    Filed: December 29, 1999
    Date of Patent: March 4, 2003
    Assignee: Ribozyme Pharmaceuticals, incorporated
    Inventors: Leonid Beigelman, Alex Burgin, Amber Beaudry, Alexander Karpeisky, Jasenka Matulic-Adamic, David Sweedler, Shawn Zinnen
  • Nucleoside triphosphates and their incorporation into oligonucleotides
    Patent number: 6509460
    Abstract: Novel nucleoside triphosphates, methods of synthesis and process of incorporating these nucleoside triphosphates into oligonucleotides are disclosed.
    Type: Grant
    Filed: August 23, 2000
    Date of Patent: January 21, 2003
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Leonid Beigelman, Alex Burgin, Amber Beaudry, Alexander Karpeisky, Jasenka Matulic-Adamic, David Sweedler
  • 2?-O-amino-containing nucleoside analogs and polynucleotides
    Patent number: 6506888
    Abstract: Novel nucleoside or nucleotide analogs comprising 2′-O-amino residues, processes for their synthesis and incorporation into polynucleotides.
    Type: Grant
    Filed: September 19, 2000
    Date of Patent: January 14, 2003
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Alexander Karpeisky, Leonid Beigelman
  • Nucleotide triphosphates and their incorporation into oligonucleotides
    Publication number: 20030004122
    Abstract: The present invention relates to novel nucleotide triphosphates, methods of synthesis and process of incorporating these nucleotide triphosphates into oligonucleotides, and isolation of novel nucleic acid catalysts (e.g., ribozymes or DNAzymes). Also, provided are the use of novel enzymatic nucleic acid molecules to inhibit HER2/neu/ErbB2 gene expression and their applications in human therapy.
    Type: Application
    Filed: April 4, 2001
    Publication date: January 2, 2003
    Inventors: Leonid Beigelman, Alex Burgin, Amber Beaudry, Alexander Karpeisky, Jasenka Matulic-Adamic, David Sweedler, Shawn Zinnen
  • 2'-deoxy-2'-alkylnucleotide containing nucleic acid
    Publication number: 20020197684
    Abstract: 2′-deoxy-2′-alkylnucleotides useful for stabilizing enzymatic nucleic acid molecules and antisense molecules.
    Type: Application
    Filed: March 21, 2002
    Publication date: December 26, 2002
    Applicant: Ribozyme Pharmaceuticals, Inc.
    Inventors: Nassim Usman, Alexander Karpeisky, Leonid Beigelman, Anil Modak
  • Nucleoside triphosphates and their incorporation into oligonucleotides
    Patent number: 6482932
    Abstract: Novel nucleotide triphosphates, methods of synthesis and process of incorporating these nucleotide triphosphates into oligonucleotides, and isolation of novel nucleic acid catalysts (e.g., ribozymes) are disclosed.
    Type: Grant
    Filed: April 28, 1999
    Date of Patent: November 19, 2002
    Assignee: Ribozyme Pharmaceuticals, Incorporated
    Inventors: Leonid Beigelman, Alex Burgin, Amber Beaudry, Alexander Karpeisky, Jasenka Matulic-Adamic, David Sweedler, Shawn Zinnen
  • Methods for synthesizing nucleosides, nucleoside derivatives and non-nucleoside derivatives
    Publication number: 20020150936
    Abstract: The present invention provides methods for the chemical synthesis of nucleosides and derivatives thereof, including 2′-amino, 2′-N-phthaloyl, 2′-O-methyl, 2′-O-silyl, 2′-O-triisopropylsilyloxymethyl, 2′-OH nucleosides, C-nucleosides, nucleoside phosphoramidites, C-nucleoside phosphoramidites, and non-nucleoside derivatives.
    Type: Application
    Filed: January 11, 2002
    Publication date: October 17, 2002
    Inventors: Leonid Beigelman, Alexander Karpeisky, Vladmir Serebryany, Peter Haeberli, David Sweedler
  • Nucleic acid molecules with novel chemical compositions capable of modulating gene expression
    Publication number: 20020142980
    Abstract: The invention features nucleic acid molecules with novel combinations of chemical modifications which are able to modulate gene expression.
    Type: Application
    Filed: May 25, 2001
    Publication date: October 3, 2002
    Inventors: James Thompson, Leonid Beigelman, James McSwiggen, Alexander Karpeisky, Laurent Bellon, Mark Reynolds, Michael Zwick, Thale Jarvis, Tod Woolf, Peter Haeberli, Jasenka Matulic-Adamic
  • Methods for synthesizing nucleosides, nucleoside derivatives and non-nucleoside derivatives
    Publication number: 20020120129
    Abstract: The present invention provides methods for the chemical synthesis of nucleosides and derivatives thereof, including 2′-amino, 2′-N-phthaloyl, 2′-O-methyl, 2′-O-silyl, 2′OH nucleosides, C-nucleosides, nucleoside phosphoramidites, C-nucleoside phosphoramidites, and non-nucleoside derivatives.
    Type: Application
    Filed: August 31, 2001
    Publication date: August 29, 2002
    Inventors: Leonid Beigelman, Alexander Karpeisky, Vladmir Serebryany, Peter Haeberli, David Sweedler
  • 2?-deoxy-2?-alkylnucleotide containing nucleic acid
    Patent number: 6365374
    Abstract: 2′-deoxy-2′-alkylnucleotides useful for stabilizing enzymatic nucleic acid molecules and antisense molecules.
    Type: Grant
    Filed: August 18, 1999
    Date of Patent: April 2, 2002
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Nassim Usman, Alexander Karpeisky, Leonid Beigelman, Anil Modak
  • Nucleoside analogs
    Patent number: 6248878
    Abstract: Novel nucleoside analogs, such as 3-(&bgr;-D-Ribofuranosyl)-2-fluoropyridine, 3-(&bgr;-D-Ribofuranosyl)-pyridin-2-one, 3-(&bgr;-D-Ribofuranosyl)-pyridin-2-(4-nitrophenylethyl)-one, 3-(&agr;-D-Ribofuranosyl)-2-fluoropyridine, 5-(&bgr;-D-Ribofuranosyl)-2-bromopyridine, 5-(&agr;-D-Ribofuranosyl)-2-bromopyridine, 5-(&bgr;-D-Ribofuranosyl)-pyridin-2-one, 5-(&agr;-D-Ribofuranosyl)-pyridin-2-one, 5-(&bgr;-D-Ribofuranosyl)-2-aminopyridine, 5-(&bgr;-D-Ribofuranosyl)-pyridin-2-(4-nitrophenylethyl)-one, and 5-(&agr;-D-Ribofuranosyl)-2-aminopyridine; process for their synthesis and incorporation into polynucleotides.
    Type: Grant
    Filed: November 21, 1997
    Date of Patent: June 19, 2001
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Jasenka Matulic-Adamic, Leonid Beigelman, Alexander Karpeisky
  • 2'-O-amino-containing nucleoside analogs and polynucleotides
    Patent number: 6159951
    Abstract: Novel nucleoside or nucleotide analogs comprising 2'-O-amino residues, processes for their synthesis and incorporation into polynucleotides.
    Type: Grant
    Filed: December 2, 1997
    Date of Patent: December 12, 2000
    Assignee: Ribozyme Pharmaceuticals Inc.
    Inventors: Alexander Karpeisky, Leonid Beigelman
  • Nucleoside triphosphates and their incorporation into oligonucleotides
    Patent number: 6127535
    Abstract: Novel nucleoside triphosphates, methods of synthesis and process of incorporating these nucleoside triphosphates into oligonucleotides are disclosed.
    Type: Grant
    Filed: November 4, 1998
    Date of Patent: October 3, 2000
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Leonid Beigelman, Alex Burgin, Amber Beaudry, Alexander Karpeisky, Jasenka Matulic-Adamic, David Sweedler
  • Enzymatic nucleic acids containing 5'-and/or 3'-cap structures
    Patent number: 5998203
    Abstract: An enzymatic nucleic acid molecule comprising a 5'- and/or a 3'-cap structure, wherein said structure is not a 5'-5'-linked inverted nucleotide or a 3'-3'-linked inverted nucleotide.
    Type: Grant
    Filed: April 16, 1996
    Date of Patent: December 7, 1999
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Jasenka Matulic-Adamic, Leonid Beigelman, Alexander Karpeisky, Thale Jarvis, Nassim Usman, Anthony DiRenzo, Francine Wincott
  • 2'-deoxy-2'-alkylnucleotide containing nucleic acid
    Patent number: 5985621
    Abstract: 2'-deoxy-2'-alkylnucleotides useful for stabilizing enzymatic nucleic acid molecules and antisense molecules.
    Type: Grant
    Filed: September 12, 1996
    Date of Patent: November 16, 1999
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Nassim Usman, Alexander Karpeisky, Leonid Beigelman, Anil Modak
  • Chemical syntheses of 2'-O-methoxy purine nucleosides
    Patent number: 5962675
    Abstract: Several processes for the chemical synthesis of 2'-O-methoxy purine nucleosides are herein disclosed.
    Type: Grant
    Filed: December 23, 1996
    Date of Patent: October 5, 1999
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Leonid Beigelman, David Sweedler, Peter Haeberli, Alexander Karpeisky
  • 2'-deoxy-2'alkylnucleotide containing nucleic acid
    Patent number: 5639647
    Abstract: 2'-deoxy-2'-alkylnucleotides useful for stabilizing enzymatic nucleic acid molecules and antisense molecules are disclosed.
    Type: Grant
    Filed: March 29, 1994
    Date of Patent: June 17, 1997
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Nassim Usman, Alexander Karpeisky, Leonid Beigelman, Anil Modak
  • 2'deoxy-2'-alkylnucleotide containing nucleic acid
    Patent number: 5627053
    Abstract: 2'-deoxy-2'-alkylnucleotides useful for stabilizing enzymatic nucleic acid molecules and antisense molecules.
    Type: Grant
    Filed: May 2, 1995
    Date of Patent: May 6, 1997
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Nassim Usman, Alexander Karpeisky, Leonid Beigelman, Anil Modak