Patents by Inventor Alexander Keith Stewart

Alexander Keith Stewart has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND MATERIALS FOR IDENTIFYING MYELOMA STAGE AND DRUG SENSITIVITY AND TREATING MYELOMA
    Publication number: 20240150843
    Abstract: Methods and materials for identifying and treating mammals (e.g., humans) having multiple myeloma (MM) are provided herein. For example, this document provides methods and materials that can be used to identify and treat mammals having advanced stage MM, and/or having MVI that is resistant to treatment with immunomodulatory drugs (IMiDs) and/or proteasome inhibitors (PIs).
    Type: Application
    Filed: March 17, 2022
    Publication date: May 9, 2024
    Inventors: Xianfeng Chen, Yuan Xiao Zhu, Alexander Keith Stewart, Lisa M. Rimsza
  • Inhibiting G protein coupled receptor 6 kinase polypeptides
    Patent number: 10252984
    Abstract: This document relates to inhibitors of G protein coupled receptor 6 kinase (GRK6) polypeptides as well as methods and materials for using such inhibitors to treat hematological malignancies, inflammation diseases, and autoimmune disorders.
    Type: Grant
    Filed: October 26, 2012
    Date of Patent: April 9, 2019
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Alexander Keith Stewart, Artem Plekhov, Robert Greenhouse
  • Small molecule inhibitors of G protein coupled receptor 6 kinases polypeptides
    Patent number: 9902739
    Abstract: This document relates to inhibitors of G protein coupled receptor 6 kinase (GRK6) polypeptides as well as methods and materials for using such inhibitors to treat hematological malignancies, inflammation diseases, and autoimmune disorders.
    Type: Grant
    Filed: April 21, 2015
    Date of Patent: February 27, 2018
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Alexander Keith Stewart, Brian Rich, Nikolai Sepetov, Robert Greenhouse, Artem Plekhov, Wen Yang, Zhiwei Tong
  • Methods and materials for assessing responsiveness to lenalidomide, thalidomide, and/or other thalidomide analogs
    Patent number: 9662319
    Abstract: This document provides methods and materials related to assessing responsiveness to lenalidomide, thalidomide, and/or other IMiDs (structural and functional analogues of thalidomide that represent a promising new class of immunomodulators). For example, methods and materials for using CRBN levels to determine whether or not cancer cells (e.g., multiple myeloma cells) are susceptible to lenalidomide, thalidomide, and/or other IMiDs are provided.
    Type: Grant
    Filed: March 8, 2012
    Date of Patent: May 30, 2017
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Alexander Keith Stewart, Peter Bergsagel, Rafael Fonseca, Esteban Braggio
  • SMALL MOLECULE INHIBITORS OF G PROTEIN COUPLED RECEPTOR 6 KINASE POLYPEPTIDES
    Publication number: 20170050939
    Abstract: This document relates to inhibitors of G protein coupled receptor 6 kinase (GRK6) polypeptides as well as methods and materials for using such inhibitors to treat hematological malignancies, inflammation diseases, and autoimmune disorders.
    Type: Application
    Filed: April 21, 2015
    Publication date: February 23, 2017
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Alexander Keith Stewart, Robert Greenhouse, Brian Rich, William Thomas, Nikolai Sepetov
  • SMALL MOLECULE INHIBITORS OF G PROTEIN COUPLED RECEPTOR 6 KINASES POLYPEPTIDES
    Publication number: 20170050979
    Abstract: This document relates to inhibitors of G protein coupled receptor 6 kinase (GRK6) polypeptides as well as methods and materials for using such inhibitors to treat hematological malignancies, inflammation diseases, and autoimmune disorders.
    Type: Application
    Filed: April 21, 2015
    Publication date: February 23, 2017
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Alexander Keith Stewart, Brian Rich, Nikolai Sepetov, Robert Greenhouse, Artem Plekhov, Wen Yang, Zhiwei Tong
  • INHIBITING CYCLIN D POLYPEPTIDES
    Publication number: 20150004696
    Abstract: This document involves methods and materials related to inhibiting cyclin D polypeptide activity. For example, this document provides methods and materials that can be used to (1) identify mammals or cells in need of cyclin D polypeptide inhibition and (2) administer an agent capable of inhibiting cyclin D polypeptide activity.
    Type: Application
    Filed: July 25, 2014
    Publication date: January 1, 2015
    Inventors: Rodger E. Tiedemann, Alexander Keith Stewart, Aaron David Schimmer, Xinliang Mao
  • Inhibiting G Protein Coupled Receptor 6 Kinase Polypeptides
    Publication number: 20140309185
    Abstract: This document relates to inhibitors of G protein coupled receptor 6 kinase (GRK6) polypeptides as well as methods and materials for using such inhibitors to treat hematological malignancies, inflammation diseases, and autoimmune disorders.
    Type: Application
    Filed: October 26, 2012
    Publication date: October 16, 2014
    Inventors: Alexander Keith Stewart, Artem Plekhov, Robert Greenhouse
  • Inhibiting cyclin D polypeptides
    Patent number: 8822440
    Abstract: This document involves methods and materials related to inhibiting cyclin D polypeptide activity. For example, this document provides methods and materials that can be used to (1) identify mammals or cells in need of cyclin D polypeptide inhibition and (2) administer an agent capable of inhibiting cyclin D polypeptide activity.
    Type: Grant
    Filed: October 10, 2007
    Date of Patent: September 2, 2014
    Assignees: Mayo Foundation for Medical Education and Research, University Health Network
    Inventors: Rodger E. Tiedemann, Alexander Keith Stewart, Aaron David Schimmer, Xinliang Mao
  • METHODS AND MATERIALS FOR ASSESSING RESPONSIVENESS TO LENALIDOMIDE, THALIDOMIDE, AND/OR OTHER THALIDOMIDE ANALOGS
    Publication number: 20140066480
    Abstract: This document provides methods and materials related to assessing responsiveness to lenalidomide, thalidomide, and/or other IMiDs (structural and functional analogues of thalidomide that represent a promising new class of immunomodulators). For example, methods and materials for using CRBN levels to determine whether or not cancer cells (e.g., multiple myeloma cells) are susceptible to lenalidomide, thalidomide, and/or other IMiDs are provided.
    Type: Application
    Filed: March 8, 2012
    Publication date: March 6, 2014
    Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: Alexander Keith Stewart, Peter Bergsagel, Rafael Fonseca, Esteban Braggio
  • TREATING MULTIPLE MYELOMA
    Publication number: 20130281377
    Abstract: This document relates to methods and materials for treating multiple myeloma. For example, methods and materials for using albumin-bound paclitaxel composition (e.g., Abraxane®, a paclitaxel albumin-stabilized nanoparticle formulation) to treat multiple myeloma are provided.
    Type: Application
    Filed: December 22, 2011
    Publication date: October 24, 2013
    Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: Rafael Fonseca, Alexander Keith Stewart, Peter Bergsagel, Marta Chesi
  • INHIBITING CYCLIN D POLYPEPTIDES
    Publication number: 20100144685
    Abstract: This document involves methods and materials related to inhibiting cyclin D polypeptide activity. For example, this document provides methods and materials that can be used to (1) identify mammals or cells in need of cyclin D polypeptide inhibition and (2) administer an agent capable of inhibiting cyclin D polypeptide activity.
    Type: Application
    Filed: October 10, 2007
    Publication date: June 10, 2010
    Inventors: Rodger E. Tiedemann, Alexander Keith Stewart, Aaron David Schimmer, Xinliang Mao