Patents by Inventor Alexander Kholomeev
Alexander Kholomeev has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11817301Abstract: A signal processing unit comprises: at least one data signal input line adapted to receive a measured data signal generated by an image current, the measured data signal comprising an added crosstalk signal induced by a source of electromagnetic disturbance; at least one disturbance signal input line adapted to receive a decoupled disturbance signal, extracted from the source of electromagnetic disturbance; an output line adapted to supply a compensated data signal; a conditioning module, to which the decoupled disturbance signal is supplied via the disturbance signal input line and which provides a compensation signal; and an adding module, to which the measured data signal and the compensation signal are provided and in which the measured data signal and the compensation signal are superposed, whereby the decoupled disturbance signal is conditioned by the conditioning module such that the compensation signal essentially corresponds to an inverted added crosstalk signal.Type: GrantFiled: June 10, 2022Date of Patent: November 14, 2023Assignee: Thermo Fisher Scientific (Bremen) GmbHInventors: Alexander Kholomeev, Gregor Quiring, Frank Czemper
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Publication number: 20230118221Abstract: A mass spectrometer comprises: a first ion optical device in a relatively low gas pressure region; a second ion optical device in a relatively high gas pressure region, the first and second ion optical devices receiving respective RF voltages from respective RF power supplies for generating respective RF fields that confine ions in respective trapping regions of the ion optical devices; and a gas conductance restriction, restricting gas flow from the relatively high gas pressure region to the relatively low gas pressure region, the gas conductance restriction having an aperture to allow ions to pass from the second to the first ion optical device. The first and second RF power supplies are independent to allow the RF voltages for generating the first RF field to have a different amplitude from the RF voltages for generating the second RF field.Type: ApplicationFiled: October 17, 2022Publication date: April 20, 2023Inventors: Hamish Stewart, Anastassios Giannakopulos, Alexander Kholomeev, Dmitry Grinfeld, Alexander Makarov, Christian Hock, Matthias Biel, Alexander Wagner
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Publication number: 20220301841Abstract: A signal processing unit comprises: at least one data signal input line adapted to receive a measured data signal generated by an image current, the measured data signal comprising an added crosstalk signal induced by a source of electromagnetic disturbance; at least one disturbance signal input line adapted to receive a decoupled disturbance signal, extracted from the source of electromagnetic disturbance; an output line adapted to supply a compensated data signal; a conditioning module, to which the decoupled disturbance signal is supplied via the disturbance signal input line and which provides a compensation signal; and an adding module, to which the measured data signal and the compensation signal are provided and in which the measured data signal and the compensation signal are superposed, whereby the decoupled disturbance signal is conditioned by the conditioning module such that the compensation signal essentially corresponds to an inverted added crosstalk signal.Type: ApplicationFiled: June 10, 2022Publication date: September 22, 2022Inventors: Alexander KHOLOMEEV, Gregor QUIRING, Frank CZEMPER
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Patent number: 11361952Abstract: There is disclosed a method for eliminating an added crosstalk signal from a measured data signal, which is generated by an image current. There is further disclosed a signal processing unit for carrying out the method. There is still further disclosed a mass spectrometer and a mass analyser comprising the signal processing unit for carrying out the method. There is yet still further disclosed a Fourier transform mass spectrometer configured to eliminate the added crosstalk signal from a measured data signal.Type: GrantFiled: January 22, 2021Date of Patent: June 14, 2022Assignee: Thermo Fisher Scientific (Bremen) GmbHInventors: Alexander Kholomeev, Gregor Quiring, Frank Czemper
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Patent number: 11087969Abstract: A method for controlling the filling of an ion trap with a predetermined quantity of ions. The method comprises generating an ion current by transmitting ions along an ion path to an ion trap, such that ions are accumulated in the ion trap over a transmission time period, wherein the magnitude of the ion current varies in time. The method further comprises detecting at an ion detector at least some ions from the source of ions during a plurality of distinct sampling time intervals interspersed within the transmission time period, and setting the duration of the transmission time period based on the detection of ions at the ion detector. The time difference between the start of a sampling time interval and the start of an immediately subsequent sampling time interval is less than a timescale for variation of the magnitude of the ion current. A controller for controlling the filling of an ion trap with a predetermined quantity of ions and a mass spectrometer comprising the controller is also described.Type: GrantFiled: May 1, 2020Date of Patent: August 10, 2021Assignee: Thermo Fisher Scientific (Bremen) GmbHInventors: Amelia Corinne Peterson, Jan-Peter Hauschild, Alexander Kholomeev, Alexander A. Makarov
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Publication number: 20210142994Abstract: There is disclosed a method for eliminating an added crosstalk signal from a measured data signal, which is generated by an image current. There is further disclosed a signal processing unit for carrying out the method. There is still further disclosed a mass spectrometer and a mass analyser comprising the signal processing unit for carrying out the method. There is yet still further disclosed a Fourier transform mass spectrometer configured to eliminate the added crosstalk signal from a measured data signal.Type: ApplicationFiled: January 22, 2021Publication date: May 13, 2021Inventors: Alexander KHOLOMEEV, Gregor QUIRING, Frank CZEMPER
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Patent number: 10903061Abstract: There is disclosed a method for eliminating an added crosstalk signal from a measured data signal, which is generated by an image current. There is further disclosed a signal processing unit for carrying out the method. There is still further disclosed a mass spectrometer and a mass analyser comprising the signal processing unit for carrying out the method. There is yet still further disclosed a Fourier transform mass spectrometer configured to eliminate the added crosstalk signal from a measured data signal.Type: GrantFiled: November 28, 2018Date of Patent: January 26, 2021Assignee: Thermo Fisher Scientific (Bremen) GmbHInventors: Alexander Kholomeev, Gregor Quiring, Frank Czemper
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Publication number: 20200373146Abstract: An ion trap 1 comprises one ejection electrode 2 for ion trapping having an opening 4, through which ions in the ion trap 1 can be ejected in an ejection direction E and further electrodes 3 for ion trapping, wherein the ejection electrode 2 and the further electrodes 3 are elongated in a longitudinal direction L. The angle ? between the longitudinal direction L and the ejection direction E is nearly 90°. The ion trap 1 comprises a primary winding 5 connected to an RF power supply 6, a secondary winding 7 coupling with the primary winding 5 for transforming the RF voltage of the RF power supply 6 supplying the transformed RF signals to the ejection electrode 2 and secondary windings 7? coupling with the primary winding 5 for transforming the RF voltage of the RF power supply 6 supplying the transformed RF signals to the further electrodes 3.Type: ApplicationFiled: May 20, 2020Publication date: November 26, 2020Inventors: Jan-Peter Hauschild, Alexander A. Makarov, Alexander Kholomeev, Dmitry Grinfeld, Eduard V. Dennisov, Amelia Corinne Peterson
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Publication number: 20200357627Abstract: A method for controlling the filling of an ion trap with a predetermined quantity of ions. The method comprises generating an ion current by transmitting ions along an ion path to an ion trap, such that ions are accumulated in the ion trap over a transmission time period, wherein the magnitude of the ion current varies in time. The method further comprises detecting at an ion detector at least some ions from the source of ions during a plurality of distinct sampling time intervals interspersed within the transmission time period, and setting the duration of the transmission time period based on the detection of ions at the ion detector. The time difference between the start of a sampling time interval and the start of an immediately subsequent sampling time interval is less than a timescale for variation of the magnitude of the ion current. A controller for controlling the filling of an ion trap with a predetermined quantity of ions and a mass spectrometer comprising the controller is also described.Type: ApplicationFiled: May 1, 2020Publication date: November 12, 2020Inventors: Amelia Corinne Peterson, Jan-Peter Hauschild, Alexander Kholomeev, Alexander A. Makarov
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Publication number: 20190198303Abstract: There is disclosed a method for eliminating an added crosstalk signal from a measured data signal, which is generated by an image current. There is further disclosed a signal processing unit for carrying out the method. There is still further disclosed a mass spectrometer and a mass analyser comprising the signal processing unit for carrying out the method. There is yet still further disclosed a Fourier transform mass spectrometer configured to eliminate the added crosstalk signal from a measured data signal.Type: ApplicationFiled: November 28, 2018Publication date: June 27, 2019Inventors: Alexander KHOLOMEEV, Gregor QUIRING, Frank CZEMPER
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Patent number: 9911586Abstract: A method of switching between two modes of power supply to a mass analyzer is provided. In a first mode of operation, operated for a first predefined time duration, a first power supply, coupled to the mass analyzer, generates a first non-zero potential, while a second power supply, disconnected from the mass analyzer, generates a second non-zero potential. In a second mode of operation, operated for a second predefined time duration, the second potential is coupled to the mass analyzer, while the first power supply, disconnected from the mass analyzer, generates the first potential. These predefined time durations are selected such that only one of: the first potential; and the second potential is coupled to the mass analyzer at any time, and such that the first and second modes of operation are carried out at least once within a predetermined length of time.Type: GrantFiled: May 15, 2015Date of Patent: March 6, 2018Assignee: Thermo Fisher Scientific (Bremen) GmbHInventors: Alexander Makarov, Alexander Kholomeev
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Patent number: 9698002Abstract: A method of mass analysis and a mass spectrometer are provided wherein a batch of ions is accumulated in a mass analyzer; the batch of ions accumulated in the mass analyzer is detected using image current detection to provide a detected signal; the number of ions in the batch of ions accumulated in the mass analyzer is controlled using an algorithm based on a previous detected signal obtained using image current detection from a previous batch of ions accumulated in the mass analyzer; wherein one or more parameters of the algorithm are adjusted based on a measurement of ion current or charge obtained using an independent detector located outside of the mass analyzer.Type: GrantFiled: April 18, 2016Date of Patent: July 4, 2017Assignee: Thermo Fisher Scientific (Bremen) GmbHInventors: Jan-Peter Hauschild, Oliver Lange, Ulf Fröhlich, Andreas Wieghaus, Alexander Kholomeev, Alexander Makarov
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Patent number: 9530632Abstract: A detection system and a method for detecting ions which have been separated in a time-of-flight (TOF) mass analyzer, comprising an amplifying arrangement for converting ions into packets of secondary particles and amplifying the packets of secondary particles, wherein the amplifying arrangement is arranged so that each packet of secondary particles produces at least a first output and a second output separated in time and so that during the delay between producing the first and second output the first output produced by a packet of secondary particles is used for modulating the second output produced by the same packet. An increased dynamic range of detection and protection of the detection system against intense ion pulses is thereby provided.Type: GrantFiled: December 10, 2015Date of Patent: December 27, 2016Assignee: Thermo Fisher Scientific (Bremen) GmbHInventors: Alexander Kholomeev, Alexander Alekseevich Makarov
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Patent number: 9496123Abstract: A mass analyzer in which ions form packets that oscillate with a period has an ion detector comprising: a detection arrangement; and compensation circuitry. The detection arrangement may comprise: a plurality of detection electrodes detecting image current signals from ions in the mass analyzer; and a preamplifier, providing an output based on the image current signals. The compensation circuitry provides a compensation signal to a respective compensatory part of the detection arrangement, based on one or more of the image current signals. A capacitance between each of the compensatory parts of the detection arrangement and a signal-carrying part of the detection arrangement affects the signal-to-noise ratio of the preamplifier output. A generator may provide a trapping field defining an ion trapping volume and a shielding conductor may be positioned between two detection electrodes, with a controller applying a voltage to the shielding conductor based on a detected image current.Type: GrantFiled: May 23, 2016Date of Patent: November 15, 2016Assignee: Thermo Fisher Scientific (Bremen) GmbHInventors: Alexander Kholomeev, Alexander Alekseevich Makarov
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Patent number: 9472385Abstract: The present invention provides a radio frequency (RF) power supply in a mass spectrometer. The power supply provides an RF signal to electrodes of a storage device to create a trapping field. The RF field is usually collapsed prior to ion ejection. In an illustrative embodiment the RF power supply includes a RF signal supply; a coil arranged to receive the signal provided by the RF signal supply and to provide an output RF signal for supply to electrodes of an ion storage device; and a shunt including a switch operative to switch between a first open position and a second closed position in which the shunt shorts the coil output.Type: GrantFiled: April 2, 2015Date of Patent: October 18, 2016Assignee: Thermo Finnigan LLCInventors: Alexander A. Makarov, Eduard V. Denisov, Alexander Kholomeev
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Publication number: 20160268118Abstract: A mass analyser in which ions form packets that oscillate with a period has an ion detector comprising: a detection arrangement; and compensation circuitry. The detection arrangement may comprise: a plurality of detection electrodes detecting image current signals from ions in the mass analyser; and a preamplifier, providing an output based on the image current signals. The compensation circuitry provides a compensation signal to a respective compensatory part of the detection arrangement, based on one or more of the image current signals. A capacitance between each of the compensatory parts of the detection arrangement and a signal-carrying part of the detection arrangement affects the signal-to-noise ratio of the preamplifier output. A generator may provide a trapping field defining an ion trapping volume and a shielding conductor may be positioned between two detection electrodes, with a controller applying a voltage to the shielding conductor based on a detected image current.Type: ApplicationFiled: May 23, 2016Publication date: September 15, 2016Inventors: Alexander KHOLOMEEV, Alexander Alekseevich MAKAROV
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Publication number: 20160233078Abstract: A method of mass analysis and a mass spectrometer are provided wherein a batch of ions is accumulated in a mass analyser; the batch of ions accumulated in the mass analyser is detected using image current detection to provide a detected signal; the number of ions in the batch of ions accumulated in the mass analyser is controlled using an algorithm based on a previous detected signal obtained using image current detection from a previous batch of ions accumulated in the mass analyser; wherein one or more parameters of the algorithm are adjusted based on a measurement of ion current or charge obtained using an independent detector located outside of the mass analyser.Type: ApplicationFiled: April 18, 2016Publication date: August 11, 2016Inventors: Jan-Peter HAUSCHILD, Oliver LANGE, Ulf FRÖHLICH, Andreas WIEGHAUS, Alexander KHOLOMEEV, Alexander MAKAROV
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Patent number: 9349579Abstract: A mass analyzer in which ions form packets that oscillate with a period has an ion detector comprising: a detection arrangement; and compensation circuitry. The detection arrangement may comprise: a plurality of detection electrodes detecting image current signals from ions in the mass analyzer; and a preamplifier, providing an output based on the image current signals. The compensation circuitry provides a compensation signal to a respective compensatory part of the detection arrangement, based on one or more of the image current signals. A capacitance between each of the compensatory parts of the detection arrangement and a signal-carrying part of the detection arrangement affects the signal-to-noise ratio of the preamplifier output. A generator may provide a trapping field defining an ion trapping volume and a shielding conductor may be positioned between two detection electrodes, with a controller applying a voltage to the shielding conductor based on a detected image current.Type: GrantFiled: May 14, 2012Date of Patent: May 24, 2016Inventors: Alexander Kholomeev, Alexander A. Makarov
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Patent number: 9324547Abstract: A method of mass analysis and a mass spectrometer are provided wherein a batch of ions is accumulated in a mass analyzer; the batch of ions accumulated in the mass analyzer is detected using image current detection to provide a detected signal; the number of ions in the batch of ions accumulated in the mass analyzer is controlled using an algorithm based on a previous detected signal obtained using image current detection from a previous batch of ions accumulated in the mass analyzer; wherein one or more parameters of the algorithm are adjusted based on a measurement of ion current or charge obtained using an independent detector located outside of the mass analyzer.Type: GrantFiled: May 18, 2012Date of Patent: April 26, 2016Assignee: Thermo Fisher Scientific (Bremen) GmbHInventors: Jan-Peter Hauschild, Oliver Lange, Ulf Froehlich, Andreas Wieghaus, Alexander Kholomeev, Alexander Makarov
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Publication number: 20160111267Abstract: A detection system and a method for detecting ions which have been separated in a time-of-flight (TOF) mass analyzer, comprising an amplifying arrangement for converting ions into packets of secondary particles and amplifying the packets of secondary particles, wherein the amplifying arrangement is arranged so that each packet of secondary particles produces at least a first output and a second output separated in time and so that during the delay between producing the first and second output the first output produced by a packet of secondary particles is used for modulating the second output produced by the same packet. An increased dynamic range of detection and protection of the detection system against intense ion pulses is thereby provided.Type: ApplicationFiled: December 10, 2015Publication date: April 21, 2016Inventors: Alexander KHOLOMEEV, Alexander Alekseevich MAKAROV