Patents by Inventor Alexander Kiselyov

Alexander Kiselyov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATORY, CARDIOVASCULAR AND CNS DISORDERS
    Publication number: 20120183522
    Abstract: The present invention relates to a genus of biaryl compounds containing at least one further ring. The compounds are PDE4 inhibitors useful for the treatment and prevention of stroke, myocardial infarct and cardiovascular inflammatory diseases and disorders.
    Type: Application
    Filed: March 26, 2012
    Publication date: July 19, 2012
    Applicant: DECODE GENETICS EHF
    Inventors: Jasbir Singh, Mark E. Gurney, Alex Burgin, Vincent Sandanayaka, Alexander Kiselyov, Adalie Motta, Gary Schiltz, Georgeta Hategan, Timothy Hagen
  • SUBSTITUTED ALKYLAMINE DERIVATIVES AND METHODS OF USE
    Publication number: 20120065185
    Abstract: Selected heterocyclic compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like.
    Type: Application
    Filed: November 15, 2011
    Publication date: March 15, 2012
    Applicant: Amgen Inc.
    Inventors: Guoqing CHEN, Jeffrey Adams, Jean Bemis, Shon Booker, Guolin Cai, Lucian Di Pietro, Celia Dominguez, Daniel Elbaum, Julie Germain, Stephanie Geuns-Meyer, Michael Handley, Qi Huang, Joseph L. Kim, Tae-Seong Kim, Alexander Kiselyov, Xiaohu Ouyang, Vinod F. Patel, Leon M. Smith, Markian Stec, Andrew Tasker, Ning Xi, Shimin Xu, Chester Chenguang Yuan, Michael Croghan
  • COMPOUNDS FOR BINDING TO ER ALPHA/BETA AND GPR30, METHODS OF TREATING DISEASE STATES AND CONDITIONS MEDIATED THROUGH THESE RECEPTORS AND IDENTIFICATION THEREOF
    Publication number: 20110092533
    Abstract: The current invention is in the field of molecular biology/pharmacology and provides compounds which modulate the effects of GPR30 as well as the classical estrogen receptors alpha and beta (ER? and ER?). These compounds may function as agonists and/or antagonists of one or more of the disclosed estrogen receptors.
    Type: Application
    Filed: December 14, 2010
    Publication date: April 21, 2011
    Applicant: STC. UNM
    Inventors: Eric R. PROSSNITZ, Sergey E. Tkatchenko, Chetana M. Revankar, Larry A. Sklar, Jeffrey B. Arterburn, Daniel F. Cimino, Tudor I. Oprea, Cristian-George Bologa, Bruce S. Edwards, Alexander Kiselyov, Susan M. Young
  • Compounds for binding to ER?/? and GPR30, methods of treating disease states and conditions mediated through these receptors and identification thereof
    Patent number: 7875721
    Abstract: The current invention is in the field of molecular biology/pharmacology and provides compounds which modulate the effects of GPR30 as well as the classical estrogen receptors alpha and beta (ER? and ER?). These compounds may function as agonists and/or antagonists of one or more of the disclosed estrogen receptors.
    Type: Grant
    Filed: August 2, 2006
    Date of Patent: January 25, 2011
    Assignee: STC.UNM
    Inventors: Eric R. Prossnitz, Sergey E. Tkatchenko, Chetana M. Revankar, Larry A. Sklar, Jeffrey B. Arterburn, Daniel F. Cimino, Tudor I. Oprea, Cristian-George Bologa, Bruce S. Edwards, Alexander Kiselyov, Susan M. Young
  • Mono, di and tri cyclic compounds useful for lowering IgE concentrations
    Patent number: 7649113
    Abstract: The present invention is directed to novel compounds which are derivatives of minocycline or doxycycline, pharmaceutical compositions containing same and use thereof in lowering excess IgE levels in a mammal suffering from a disease where IgE is pathogenic.
    Type: Grant
    Filed: August 25, 2008
    Date of Patent: January 19, 2010
    Assignee: The Research Foundation of State University of New York
    Inventors: Helen G. Durkin, Martin H. Bluth, Tamar A. Smith-Norowitz, Rauno Joks, Alexander Kiselyov
  • BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATORY, CARDIOVASCULAR AND CNS DISORDERS
    Publication number: 20090324569
    Abstract: The present invention relates to a genus of biaryl compounds containing at least one further ring. The compounds are PDE4 inhibitors useful for the treatment and prevention of stroke, myocardial infarct and cardiovascular inflammatory diseases and disorders.
    Type: Application
    Filed: November 20, 2008
    Publication date: December 31, 2009
    Applicant: DECODE GENETICS EHF
    Inventors: Jasbir Singh, Mark E. Gurney, Alex Burgin, Vincent Sandanayaka, Alexander Kiselyov, Adalie Motta, Gary Schiltz, Georgeta Hategan, Timothy Hagen
  • Heterocyclic compounds and their use as anticancer agents
    Publication number: 20090318438
    Abstract: The present invention relates to heterocyclic compounds that have anticancer activity, and pharmaceutical compositions that contain such compounds, methods of treating diseases and conditions in mammals using such compounds and composition and methods for their manufacture.
    Type: Application
    Filed: September 25, 2008
    Publication date: December 24, 2009
    Inventors: Xiaoling Chen, Hai-Ying He, Joel Kawakami, Alexander Kiselyov, Xiaohu Ouyang, Vatee Pattaropong, Evgueni Piatnitski, Maria Carolina Tuma, John Kincaid
  • BIARYL PDE4 INHIBITORS FOR TREATING PULMONARY AND CARDIOVASCULAR DISORDERS
    Publication number: 20090136473
    Abstract: The present invention relates to a genus of biaryl compounds containing at least one further ring. The compounds are PDE4 inhibitors useful for the treatment and prevention of stroke, myocardial infarct and cardiovascular inflammatory diseases and disorders.
    Type: Application
    Filed: November 20, 2008
    Publication date: May 28, 2009
    Applicant: DECODE GENETICS EHF
    Inventors: Jasbir Singh, Mark E. Gurney, Alex Burgin, Alexander Kiselyov, Munagala Rao, Timothy Hagen
  • SUBSTITUTED BENZOAZOLE PDE4 INHIBITORS FOR TREATING PULMONARY AND CARDIOVASCULAR DISORDERS
    Publication number: 20090130076
    Abstract: The invention relates to substituted benzothiazoles, benzoxazoles—and their counterparts having pyridine and pyrimidine rings replacing the benzene ring—that are PDE4 inhibitors useful for treating stroke, myocardial infarct, and cardiovascular inflammatory conditions, to pharmaceutical compositions comprising these compounds, and to methods for the treatment of stroke, myocardial infarct, and cardiovascular inflammatory conditions in a mammal. The compounds have general formula I: in which A and B are carbocycles or heterocycles.
    Type: Application
    Filed: November 20, 2008
    Publication date: May 21, 2009
    Applicant: DECODE GENETICS EHF
    Inventors: Jasbir Singh, Mark E. Gurney, Alex Burgin, Alexander Kiselyov, Munagala Rao
  • 4- (OR 5-) SUBSTITUTED CATECHOL DERIVATIVES
    Publication number: 20090131530
    Abstract: Compounds of the formula: are disclosed. The compounds act as phosphodiesterase-4 modulators, and useful for treating stroke, myocardial infarct, and cardiovascular inflammatory conditions. Other embodiments are also disclosed.
    Type: Application
    Filed: November 20, 2008
    Publication date: May 21, 2009
    Applicant: DECODE GENETICS EHF
    Inventors: Jasbir Singh, Mark E. Gurney, Alex Burgin, Vincent Sandanayaka, Alexander Kiselyov
  • SUBSTITUTED BENZOAZOLE PDE4 INHIBITORS FOR TREATING INFLAMMATORY, CARDIOVASCULAR AND CNS DISORDERS
    Publication number: 20090130077
    Abstract: The invention relates to substituted benzothiazoles, benzoxazoles—and their counterparts having pyridine and pyrimidine rings replacing the benzene ring—that are PDE4 inhibitors useful for treating stroke, myocardial infarct, and cardiovascular inflammatory conditions, to pharmaceutical compositions comprising these compounds, and to methods for the treatment of stroke, myocardial infarct, and cardiovascular inflammatory conditions in a mammal. The compounds have general formula I: in which A and B are carbocycles or heterocycles.
    Type: Application
    Filed: November 20, 2008
    Publication date: May 21, 2009
    Applicant: deCODE genetics ehf
    Inventors: Jasbir Singh, Mark E. Gurney, Alex Burgin, Vincent Sandanayaka, Alexander Kiselyov, Munagala Rao
  • HETEROCYCLIC COMPOUNDS AND THEIR USE AS ANTICANCER AGENTS
    Publication number: 20090048301
    Abstract: The present invention relates to heterocyclic compounds that have anticancer activity, and pharmaceutical compositions that contain such compounds, methods of treating diseases and conditions in mammals using such compounds and composition and methods for their manufacture.
    Type: Application
    Filed: July 9, 2004
    Publication date: February 19, 2009
    Applicant: IMCLONE SYSTEMS INCORPORATED
    Inventors: Xiaoling Chen, Hai-Ying He, Joel Kawakami, Alexander Kiselyov, Xiaohu Ouyang, Vatee Pattaropong, Evgueni Piatnitski, Maria Carolina Tuma, John Kincaid
  • Mono, Di & Tri Cyclic Compounds Useful for Lowering IgE Concentrations
    Publication number: 20080312470
    Abstract: The present invention is directed to novel compounds which are derivatives of minocycline or doxycycline, pharmaceutical compositions containing same and use thereof in lowering excess IgE levels in a mammal suffering from a disease where IgE is pathogenic.
    Type: Application
    Filed: August 25, 2008
    Publication date: December 18, 2008
    Applicant: The Research Foundation of State University of New York
    Inventors: Helen G. Durkin, Martin H. Bluth, Tamar A. Smith-Norowitz, Rauno Joks, Alexander Kiselyov
  • Mono di & tri cyclic compounds useful for lowering IgE concentrations
    Patent number: 7425655
    Abstract: The present invention is directed novel compounds which are derivatives of minocycline or doxycycline, pharmaceutical compositions containing same and use thereof in lowering excess IgE levels in a mammal suffering from a disease where IgE is pathogenic.
    Type: Grant
    Filed: February 9, 2004
    Date of Patent: September 16, 2008
    Assignee: The Research Foundation of State University of New York
    Inventors: Helen G. Durkin, Martin H. Bluth, Tamar A. Smith-Norowitz, Rauno Joks, Alexander Kiselyov
  • Compounds for binding to ERalpha/beta and GPR30, methods of treating disease states and conditions mediated through these receptors and identification thereof
    Publication number: 20080167334
    Abstract: The current invention is in the field of molecular biology/pharmacology and provides compounds which modulate the effects of GPR30 as well as the classical estrogen receptors alpha and beta (ER? and ER?). These compounds may function as agonists and/or antagonists of one or more of the disclosed estrogen receptors.
    Type: Application
    Filed: August 2, 2006
    Publication date: July 10, 2008
    Inventors: Eric R. Prossnitz, Sergey E. Tkatchenko, Chetana M. Revankar, Larry A. Sklar, Jeffrey B. Arterburn, Daniel F. Cimino, Tudor I. Oprea, Cristian-George Bologa, Bruce S. Edwards, Alexander Kiselyov, Susan M. Young
  • Breast stimulation and augmentation system
    Publication number: 20070104694
    Abstract: A stem-cell-seeded porous scaffold implant and electromagnetic growth stimulation for treating or augmenting a breast tissue defect in a patient.
    Type: Application
    Filed: May 1, 2006
    Publication date: May 10, 2007
    Inventors: Rodolfo Quijano, Hosheng Tu, Kenneth Williams, Robert Carter, Alexander Kiselyov
  • Breast augmentation and reconstruction system
    Publication number: 20070104695
    Abstract: A breast template for delivering stem cell formulation to a breast defect of a patient for treating or augmenting a breast tissue defect comprising a flexible band with at least one throughput hole for guiding an injecting needle to penetrate into the breast of the patient, wherein the flexible band is configured to be placed intimately against a surface of the breast.
    Type: Application
    Filed: July 20, 2006
    Publication date: May 10, 2007
    Inventors: Rodolfo Quijano, Hosheng Tu, Kenneth Williams, Robert Carter, Alexander Kiselyov
  • Breast tissue regeneration
    Publication number: 20070104692
    Abstract: A stem-cell-seeded porous scaffold implant and methods for treating a breast tissue defect in a patient.
    Type: Application
    Filed: November 7, 2005
    Publication date: May 10, 2007
    Inventors: Rodolfo Quijano, Hosheng Tu, Kenneth Williams, Robert Carter, Alexander Kiselyov
  • Mono di & tri cyclic compounds useful for lowering ige concentrations
    Publication number: 20060235081
    Abstract: The present invention is directed novel compounds which are derivatives of minocycline or doxycycline, pharmaceutical compositions containing same and use thereof in lowering excess IgE levels in a mammal suffering from a disease where IgE is pathogenic.
    Type: Application
    Filed: February 9, 2004
    Publication date: October 19, 2006
    Inventors: Helen Durkin, Martin Bluth, Tamar Smith-Norowitz, Rauno Joks, Alexander Kiselyov
  • Substituted alkylamine derivatives and methods of use
    Publication number: 20060040956
    Abstract: Selected heterocyclic compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
    Type: Application
    Filed: September 23, 2005
    Publication date: February 23, 2006
    Inventors: Guoqing Chen, Jeffrey Adams, Jean Bemis, Shon Booker, Guolin Cai, Lucian Di Pietro, Celia Dominguez, Daniel Elbaum, Julie Germain, Stephanie Geuns-Meyer, Michael Handley, Qi Huang, Joseph Kim, Tae-Seong Kim, Alexander Kiselyov, Xiaohu Ouyang, Vinod Patel, Leon Smith, Markian Stec, Andrew Tasker, Ning Xi, Shimin Xu, Chester Yuan, Michael Croghan