Patents by Inventor Alexander Klose

Alexander Klose has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11447037
    Abstract: System for regulating a charging temperature (T) of a vehicle battery (2) of a vehicle, wherein the vehicle battery (2) is cooled by means of a fluid (F) which circulates in a cooling circuit (21) of the vehicle, which is controlled by a controller (18) such that, upon reaching a charging station, the temperature of the vehicle battery (2) is pre-controlled to a desired charging start temperature (T0) which is suitable for an electrical charging procedure for speedily charging the vehicle battery (2) by means of the charging station.
    Type: Grant
    Filed: December 4, 2018
    Date of Patent: September 20, 2022
    Assignee: Klose & Oechsle GmbH
    Inventors: Alexander Klose, Oliver Oechsle
  • Patent number: 11191937
    Abstract: A method for delivering drugs into cystic fluid, the method comprising injecting a drug delivery system (DDS) into a cystic fluid space at an injection site, the DDS comprising at least one therapeutic agent encapsulated in biodegradable polymers, applying ultrasonic energy proximal to the injection site, and controlling the at least one of buoyancy, delivery location, mixing, and dispersion of the DDS to a targeted area using the ultrasonic energy.
    Type: Grant
    Filed: March 21, 2019
    Date of Patent: December 7, 2021
    Assignee: Advanced CSF Therapies, LLC
    Inventors: Jae H. Choi, Keith Baker, Alexander Klose, John Pile-Spellman
  • Publication number: 20210188127
    Abstract: System for regulating a charging temperature (T) of a vehicle battery (2) of a vehicle, wherein the vehicle battery (2) is cooled by means of a fluid (F) which circulates in a cooling circuit (21) of the vehicle, which is controlled by a controller (18) such that, upon reaching a charging station, the temperature of the vehicle battery (2) is pre-controlled to a desired charging start temperature (T0) which is suitable for an electrical charging procedure for speedily charging the vehicle battery (2) by means of the charging station.
    Type: Application
    Filed: December 4, 2018
    Publication date: June 24, 2021
    Inventors: Alexander Klose, Oliver Oechsle
  • Publication number: 20200337819
    Abstract: Systems and method for optical imaging of an animal include a body conforming animal mold, which is shaped and sized to hold an animal in an immobilized and geometrically defined position and a gantry, which can include multiple optical mirrors to provide for simultaneous imaging of multiple different views of an animal within a body conforming animal mold.
    Type: Application
    Filed: March 2, 2020
    Publication date: October 29, 2020
    Inventors: Alexander Klose, Neal Paragas
  • Patent number: 10605742
    Abstract: Exemplary systems, methods and computer accessible mediums which can determine quantitative information of a tissue(s) can be provided, which can include receiving optical information regarding the tissue(s), and determining the quantitative information of the tissue(s), in real time and during the receipt of the optical information, using an atlas. The tissue(s) can be part of a mouse, and the quantitative information can be an in-vivo count of cells or bacteria in the tissue(s). The quantitative information can be determined by co-registering the in-vivo count to the atlas. The optical information can be generated using a mirror gantry(s) so as to simultaneously image at least two opposing views of the tissue(s).
    Type: Grant
    Filed: June 30, 2014
    Date of Patent: March 31, 2020
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Alexander Klose, Neal Paragas
  • Publication number: 20200086104
    Abstract: A method for delivering drugs into cystic fluid, the method comprising injecting a drug delivery system (DDS) into a cystic fluid space at an injection site, the DDS comprising at least one therapeutic agent encapsulated in biodegradable polymers, applying ultrasonic energy proximal to the injection site, and controlling the at least one of buoyancy, delivery location, mixing, and dispersion of the DDS to a targeted area using the ultrasonic energy.
    Type: Application
    Filed: March 21, 2019
    Publication date: March 19, 2020
    Inventors: Jae H. Choi, Keith Baker, Alexander Klose, John Pile-Spellman
  • Patent number: 10575934
    Abstract: Systems and method for optical imaging of an animal include a body conforming animal mold, which is shaped and sized to hold an animal in an immobilized and geometrically defined position and a gantry, which can include multiple optical mirrors to provide for simultaneous imaging of multiple different views of an animal within a body conforming animal mold.
    Type: Grant
    Filed: June 13, 2017
    Date of Patent: March 3, 2020
    Assignee: In Vivo Analytics, Inc.
    Inventors: Alexander Klose, Neal Paragas
  • Patent number: 10258781
    Abstract: A method for delivering drugs into cystic fluid, the method comprising injecting a drug delivery system (DDS) into a cystic fluid space at an injection site, the DDS comprising at least one therapeutic agent encapsulated in biodegradable polymers, applying ultrasonic energy proximal to the injection site, and controlling the at least one of buoyancy, delivery location, mixing, and dispersion of the DDS to a targeted area using the ultrasonic energy.
    Type: Grant
    Filed: June 23, 2016
    Date of Patent: April 16, 2019
    Assignee: Advanced CSF Therapies, LLC
    Inventors: Jae H. Choi, Keith Baker, Alexander Klose, John Pile-Spellman
  • Publication number: 20170354487
    Abstract: Systems and method for optical imaging of an animal include a body conforming animal mold, which is shaped and sized to hold an animal in an immobilized and geometrically defined position and a gantry, which can include multiple optical mirrors to provide for simultaneous imaging of multiple different views of an animal within a body conforming animal mold.
    Type: Application
    Filed: June 13, 2017
    Publication date: December 14, 2017
    Inventors: Alexander Klose, Neal Paragas
  • Publication number: 20160375236
    Abstract: A method for delivering drugs into cystic fluid, the method comprising injecting a drug delivery system (DDS) into a cystic fluid space at an injection site, the DDS comprising at least one therapeutic agent encapsulated in biodegradable polymers, applying ultrasonic energy proximal to the injection site, and controlling the at least one of buoyancy, delivery location, mixing, and dispersion of the DDS to a targeted area using the ultrasonic energy.
    Type: Application
    Filed: June 23, 2016
    Publication date: December 29, 2016
    Inventors: Jae H. Choi, Keith Baker, Alexander Klose, John Pile-Spellman
  • Patent number: 9047659
    Abstract: The present disclosure can provide apparatus, system, methods, and computer-accessible medium for generating particular information which is at least one of three-dimensional information or intensity information of a tissue portion which can include at least one of a tissue surface or a tissue volume. For example, the exemplary method can include determining a light intensity distribution of light provided on the tissue portion, using the light intensity distribution, determining one or more attenuation maps of the tissue portion, obtaining one or more multispectral measurements of the light intensity distribution on the tissue portion taken from one or more views, and generating the particular information using an image reconstruction procedure in conjunction with data from the one or more tissue attenuation maps and the multispectral measurements.
    Type: Grant
    Filed: April 28, 2011
    Date of Patent: June 2, 2015
    Assignee: The Trustees of Columbia University in the City of New York
    Inventor: Alexander Klose
  • Publication number: 20150012224
    Abstract: Exemplary systems, methods and computer accessible mediums which can determine quantitative information of a tissue(s) can be provided, which can include receiving optical information regarding the tissue(s), and determining the quantitative information of the tissue(s), in real time and during the receipt of the optical information, using an atlas. The tissue(s) can be part of a mouse, and the quantitative information can be an in-vivo count of cells or bacteria in the tissue(s). The quantitative information can be determined by co-registering the in-vivo count to the atlas. The optical information can be generated using a mirror gantry(s) so as to simultaneously image at least two opposing views of the tissue(s).
    Type: Application
    Filed: June 30, 2014
    Publication date: January 8, 2015
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Alexander Klose, Neal Paragas
  • Publication number: 20130108132
    Abstract: The present disclosure can provide apparatus, system, methods, and computer-accessible medium for generating particular information which is at least one of three-dimensional information or intensity information of a tissue portion which can include at least one of a tissue surface or a tissue volume. For example, the exemplary method can include determining a light intensity distribution of light provided on the tissue portion, using the light intensity distribution, determining one or more attenuation maps of the tissue portion, obtaining one or more multispectral measurements of the light intensity distribution on the tissue portion taken from one or more views, and generating the particular information using an image reconstruction procedure in conjunction with data from the one or more tissue attenuation maps and the multispectral measurements.
    Type: Application
    Filed: April 28, 2011
    Publication date: May 2, 2013
    Applicant: The Trustees of Columbia University in the City of New York
    Inventor: Alexander Klose
  • Publication number: 20120049088
    Abstract: An exemplary method, system, and computer-accessible medium can be provided for generating three-dimensional image information associated with a fluorescence-exhibiting arrangement within a sample. For example, it is possible to generate a first electro-magnetic radiation, to be received in the sample, at one or more wavelengths that are associated with one or more wavelengths of emission of the fluorescence-exhibiting arrangement. In addition, it is possible to generate a second electro-magnetic radiation from the sample which is caused by the fluorescence-exhibiting arrangement in response to the first electro-magnetic radiation, and generate data associated with the second electro-magnetic radiation. Then, it is possible to receive the data, and generate three-dimensional information based on the data.
    Type: Application
    Filed: March 5, 2010
    Publication date: March 1, 2012
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventor: Alexander Klose
  • Publication number: 20120037818
    Abstract: Exemplary embodiments of a computer-accessible medium, method and system for providing information are provided. A first detection arrangement can be provided which can be configured to detect electro-magnetic radiations from a fluorescent particle(s) in a portion of a structure, and generate information associated with the portion of the structure. A second arrangement can be configured to generate a two-dimensional image and/or a three-dimensional image of the at least one portion of the structure as a function of the information. The electro-magnetic radiations can have different wavelengths.
    Type: Application
    Filed: April 30, 2010
    Publication date: February 16, 2012
    Applicant: The Trustees of Columbia University in the City of New York
    Inventor: Alexander Klose
  • Publication number: 20010032053
    Abstract: A system and method for improved image reconstruction of the internal properties of a scattering medium is provided. The reconstruction technique employs a model-based iterative image reconstruction scheme. The reconstruction algorithm comprises a forward and inverse model. The forward model of the present method and system is based on the equation of radiative transfer. The forward model predicts the transport of energy through a medium for a given set of internal properties, source positions, source strengths, and boundary conditions, for a medium to be imaged. The inverse model relates the predicted transport of energy to the actual measured energy transport through the medium to determine the actual properties of the medium.
    Type: Application
    Filed: January 22, 2001
    Publication date: October 18, 2001
    Inventors: Andreas H. Hielscher, Alexander Klose