Patents by Inventor Alexander Knuth

Alexander Knuth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Isolated nucleic acid molecules encoding cancer associated antigens, the antigens per se, and uses thereof
    Patent number: 7354992
    Abstract: The invention relates to newly identified cancer associated antigens. It has been discovered that each of these molecules provokes antibodies when expressed by a subject. The ramifications of this observation are also a part of this invention.
    Type: Grant
    Filed: December 4, 2003
    Date of Patent: April 8, 2008
    Assignees: Ludwig Institute For Cancer Research, Cornell Research Foundation, Inc.
    Inventors: Dirk Jager, Barry C. Picker, legal representative, Cynthia H. Scanlan, legal representative, Ali Gure, Elke Jager, Alexander Knuth, Lloyd Old, Yao-Tseng Chen, Elisabeth Stockert, Matthew Scanlan
  • Isolated nucleic acid molecules encoding ESO-1 peptides and uses thereof
    Patent number: 7291335
    Abstract: The invention relates to antibodies which bind to the cancer associated antigen NY-ESO-1. Both polyclonal and monoclonal antibodies are part of the invention, as are chimeric forms of the antibodies, and binding portions of antibodies. Uses of these antibodies are described. Also described are truncated, recombinant forms of the cancer associated antigen.
    Type: Grant
    Filed: December 17, 2001
    Date of Patent: November 6, 2007
    Assignee: Ludwig Institute for Cancer Research
    Inventors: Elisabeth Stockert, Elke Jäger, Yao-tseng Chen, Matthew Scanlan, Alexander Knuth, Lloyd J. Old
  • Isolated peptides corresponding to amino acid requirements of NY-ESO-1, which bind to MHC Class I and MHC Class II molecules, and uses thereof
    Publication number: 20060269960
    Abstract: The invention relates to peptides which bind to MHC Class I and to MHC Class II molecules. These peptides are useful in different therapeutic and diagnostic contexts.
    Type: Application
    Filed: August 4, 2006
    Publication date: November 30, 2006
    Inventors: Alexander Knuth, Elke Jager, Yao-tseng Chen, Matthew Scanlan, Ali Gure, Gerd Ritter, Lloyd Old, Jan Drijfhout
  • Isolated cancer associated antigens NY-MEL 1 and NY-MEL 3, peptides based thereon, and their uses
    Patent number: 7132507
    Abstract: The invention relates to isolated, cancer associated antigens, nucleic acid molecules, and various uses thereof.
    Type: Grant
    Filed: May 21, 2002
    Date of Patent: November 7, 2006
    Assignees: Ludwig Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center, Cornell Research Foundation, Inc.
    Inventors: Dirk Jager, Elizabeth Stockert, Matthew Scanlan, Ali Gure, Elke Jager, Alexander Knuth, Lloyd Old, Yao-Tseng Chen
  • Methods for detection of disease-associated antibodies in urine
    Patent number: 7125681
    Abstract: The present invention provides methods and diagnostic kits for the detection of disease-specific antibodies in urine containing sample. The present invention is also directed toward methods for determining that a patient suffers from a disorder characterized by aberrant expression of a naturally occurring gene. Methods for monitoring the status of a disorder in a patient characterized by aberrant expression of a naturally occurring gene are also provided.
    Type: Grant
    Filed: June 21, 2002
    Date of Patent: October 24, 2006
    Assignee: Ludwig Institute for Cancer Research
    Inventors: Alexander Knuth, Elke Jäger, Dirk Jäger
  • Isolated nucleic acid molecules which encode peptides which bind to MHC class II molecules, such as HLA-DR53
    Patent number: 7115729
    Abstract: The invention relates to peptides which bind to MHC Class I and to MHC Class II molecules. These peptides are useful in different therapeutic and diagnostic contexts.
    Type: Grant
    Filed: January 2, 2004
    Date of Patent: October 3, 2006
    Assignees: Cornell Research Foundation, Ludwig Institute for Cancer Research, Memorial Sloan Kettering Cancer Center
    Inventors: Alexander Knuth, Elke Jäger, Yao-tseng Chen, Matthew Scanlan, Ali Gure, Gerd Ritter, Lloyd J. Old, Jan W. Drijfhout
  • Isolated nucleic acid molecules encoding cancer associated antigens, the antigens per se, and uses thereof
    Publication number: 20060165651
    Abstract: The invention relates to newly identified cancer associated antigens. It has been discovered that each of these molecules provokes antibodies when expressed by a subject. The ramifications of this observation are also a part of this invention.
    Type: Application
    Filed: September 6, 2005
    Publication date: July 27, 2006
    Inventors: Elke Jager, Dirk Jager, Alexander Knuth
  • Isolated peptides which bind to HLA-C molecules and uses thereof
    Patent number: 7009035
    Abstract: The invention teaches peptide epitopes which bind to HLA-Cw3 and HLA-Cw6 molecules on the surface of cells. The peptides are useful diagnostically and therapeutically, as are DNA molecules which encode them, and the cytolytic T lymphocytes specific to the HLA/peptide complexes. Also a feature of the invention is a method for identifying relevant molecules such as those described herein, in a system that uses stimulation and restimulation using different viral vectors.
    Type: Grant
    Filed: October 18, 2002
    Date of Patent: March 7, 2006
    Assignees: Ludwig Institute for Cancer Research, Cornell Research Foundation, Inc., Memorial Sloan-Kettering Cancer Center
    Inventors: Sacha Gnjatic, Lloyd J. Old, Yasuhiro Nagata, Elke Jager, Yao-Tseng Chen, Alexander Knuth
  • Isolated nucleic acid molecules encoding cancer associated antigens, the antigens per se, and uses thereof
    Patent number: 6911529
    Abstract: The invention relates to newly identified cancer associated antigens. It has been discovered that each of these molecules provokes antibodies when expressed by a subject. The ramifications of this observation are also part of this invention.
    Type: Grant
    Filed: June 22, 2000
    Date of Patent: June 28, 2005
    Assignees: Ludwig Institute for Cancer Research, Cornell Research Foundation, Memorial Sloan-Kettering Cancer Center
    Inventors: Dirk Jager, Elizabeth Stockert, Matthew Scanlan, Ali Gure, Elke Jager, Alexander Knuth, Lloyd Old, Yao-tseng Chen
  • Isolated nucleic acid molecules encoding cancer associated antigens, the antigens per se, and uses thereof
    Publication number: 20050063981
    Abstract: The invention relates to newly identified cancer associated antigens. It has been discovered that each of these molecules provokes antibodies when expressed by a subject. The ramifications of this observation are also a part of this invention.
    Type: Application
    Filed: December 4, 2003
    Publication date: March 24, 2005
    Inventors: Dirk Jager, Elisabeth Stockert, Barry Picker, Matthew Scanlan, Cynthia Scanlan, Ali Gure, Elke Jager, Alexander Knuth, Lloyd Old, Yao-Tseng Chen
  • Isolated nucleic acid molecule encoding cancer associated antigens, the antigens per se, and uses thereof
    Patent number: 6830924
    Abstract: The invention relates to newly identified cancer associated antigens, referred to as CT7, KOC-2 and KOC-3. The invention also relates to observations regarding known molecule KOC-1. It has been discovered that each of these molecules provokes antibodies when expressed by a subject. The ramifications of this observation are also a part of this invention.
    Type: Grant
    Filed: March 16, 1999
    Date of Patent: December 14, 2004
    Assignees: Ludwig Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center, Cornell Research Foundation, Inc.
    Inventors: Yao-Tseng Chen, Ali Gure, Solam Tsang, Elisabeth Stockert, Elke Jager, Alexander Knuth, Lloyd J. Old
  • Isolated nucleic acid molecules which encode peptides which bind to MHC class II molecules, such as HLA-DR53
    Publication number: 20040158044
    Abstract: The invention relates to peptides which bind to MHC Class I and to MHC Class II molecules. These peptides are useful in different therapeutic and diagnostic contexts.
    Type: Application
    Filed: January 2, 2004
    Publication date: August 12, 2004
    Inventors: Alexander Knuth, Elke Jager, Yao-tseng Chen, Matthew Scanlan, Ali Gure, Gerd Ritter, Lloyd J. Old, Jan W. Drijfhout
  • Isolated nucleic acid molecules encoding cancer associated antigens, the antigens per se, and uses thereof
    Patent number: 6774226
    Abstract: The invention relates to newly identified cancer associated antigens. It has been discovered that each of these molecules provokes antibodies when expressed by a subject. The ramifications of this observation are also a part of this invention.
    Type: Grant
    Filed: November 30, 1999
    Date of Patent: August 10, 2004
    Assignees: Ludwig Institute for Cancer Research, Cornell Research Foundation, Inc.
    Inventors: Dirk Jager, Elizabeth Stockert, Matthew Scanlan, Ali Gure, Elke Jager, Alexander Knuth, Lloyd Old, Yao-tseng Chen
  • Isolated nucleic acid molecules encoding cancer associated antigens, the antigens per se, and uses thereof
    Publication number: 20040126398
    Abstract: The invention relates to newly identified cancer associated antigens. It has been discovered that each of these molecules provokes antibodies when expressed by a subject. The ranifications of this observation are also a part of this invention.
    Type: Application
    Filed: February 24, 2003
    Publication date: July 1, 2004
    Inventors: Dirk Jager, Elisabeth Stockert, Matthew Scanlan, Alexander Knuth, Lloyd Old, Ali Gure, Yao-Tseng Chen, Elke Jager
  • Isolated peptides corresponding to amino acid sequences of NY-ESO-1, which bind to MHC Class I and MHC Class II molecules, and uses thereof
    Patent number: 6723832
    Abstract: The invention relates to peptides which bind to MHC Class I and to MHC Class II molecules. These peptides are useful in different therapeutic and diagnostic contexts.
    Type: Grant
    Filed: October 2, 1998
    Date of Patent: April 20, 2004
    Assignees: Ludwig Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center, Academisch Ziekenhuis Leiden, Cornell Research Foundation
    Inventors: Alexander Knuth, Elke Jäger, Yao-tseng Chen, Matthew Scanlan, Ali Gure, Gerd Ritter, Lloyd J. Old, Jan W. Drijfhout
  • Isolated peptides which bind to HLA molecules and uses thereof
    Publication number: 20030175250
    Abstract: This invention relates to isolated peptides that bind to an HLA molecule particularly HLA-A3, HLA-B35 and/or HLA-B51 and stimulate cytolytic T cells specific for complexes of the peptide and the HLA molecule. This invention also relates to CTLs, antibodies, antibody fragments and T cell receptors that are specific for HLA/peptide complexes, and to methods of using the peptides, CTLs, antibodies and receptors.
    Type: Application
    Filed: February 12, 2003
    Publication date: September 18, 2003
    Inventors: Elke Jager, Alexander Knuth, Lloyd J. Old, Sacha Gnjatic
  • Isolated peptides which bind to HLA-C molecules and uses thereof
    Publication number: 20030050451
    Abstract: The invention teaches peptide epitopes which bind to HLA-Cw3 and HLA-Cw6 molecules on the surface of cells. The peptides are useful diagnostically and therapeutically, as are DNA molecules which encode them, and the cytolytic T lymphocytes specific to the HLA/peptide complexes. Also a feature of the invention is a method for identifying relevant molecules such as those described herein, in a system that uses stimulation and restimulation using different viral vectors.
    Type: Application
    Filed: October 18, 2002
    Publication date: March 13, 2003
    Inventors: Sacha Gnjatic, Lloyd J. Old, Yasuhiro Nagata, Elke Jager, Yao-Tseng Chen, Alexander Knuth
  • Antibodies specific for SSX proteins
    Publication number: 20030023057
    Abstract: The invention relates to members of the SSX family of genes, as well as their uses.
    Type: Application
    Filed: October 11, 2001
    Publication date: January 30, 2003
    Inventors: Ali O. Gure, Ozlem Tureci, Ugur Sahin, Solam Tsang, Matthew J. Scanlan, Alexander Knuth, Michael Pfreundschuh, Lloyd J. Old, Yao-Tseng Chen
  • Isolated cancer associated antigens NY-MEL 1 and NY-MEL 3, peptides based thereon, and their uses
    Publication number: 20030017547
    Abstract: The invention relates to isolated, cancer associated antigens, nucleic acid molecules, and various uses thereof.
    Type: Application
    Filed: May 21, 2002
    Publication date: January 23, 2003
    Inventors: Dirk Jager, Elizabeth Stockert, Matthew Scanlan, Ali Gure, Elke Jager, Alexander Knuth, Lloyd Old, Yao-Tseng Chen
  • Isolated peptides which bind to HLA-C molecules and uses thereof
    Patent number: 6506875
    Abstract: The invention teaches peptide epitopes which bind to HLA-Cw3 and HLA-Cw6 molecules on the surface of cells. The peptides are useful diagnostically and therapeutically, as are DNA molecules which encode them, and the cytolytic T lymphocytes specific to the HLA/peptide complexes. Also a feature of the invention is a method for identifying relevant molecules such as those described herein, in a system that uses stimulation and restimulation using different viral vectors.
    Type: Grant
    Filed: September 26, 2000
    Date of Patent: January 14, 2003
    Assignee: Ludwig Institute for Cancer Research
    Inventors: Sacha Gnjatic, Lloyd J. Old, Yasuhiro Nagata, Elke Jager, Yao-Tseng Chen, Alexander Knuth