Patents by Inventor Alexander Kuhn

Alexander Kuhn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11547673
    Abstract: This disclosure relates to the field of RNA to prevent or treat coronavirus infection. In particular, the present disclosure relates to methods and agents for vaccination against coronavirus infection and inducing effective coronavirus antigen-specific immune responses such as antibody and/or T cell responses. Specifically, in one embodiment, the present disclosure relates to methods comprising administering to a subject RNA encoding a peptide or protein comprising an epitope of SARS-CoV-2 spike protein (S protein) for inducing an immune response against coronavirus S protein, in particular S protein of SARS-CoV-2, in the subject, i.e., vaccine RNA encoding vaccine antigen.
    Type: Grant
    Filed: April 16, 2021
    Date of Patent: January 10, 2023
    Assignee: BioNTech SE
    Inventors: Ugur Sahin, Alptekin Güler, Andreas Kuhn, Alexander Muik, Annette Vogel, Kerstin Walzer, Sonja Witzel, Stephanie Hein, Özlem Türeci
  • Publication number: 20220363901
    Abstract: A mixture contains at least one polyether block amide (PEBA) and at least one poly(meth)acrylate, selected from poly(meth)acrylimides, poly-alkyl(meth)acrylates, and mixtures thereof. The mass ratio of PEBA to poly(meth)acrylate is 95:5 to 60:40. The polyalkyl(meth)acrylate contains 80% by weight to 99% by weight of methyl methacrylate (MMA) units and 1% by weight to 20% by weight of C1-C10-alkyl acrylate units, based on the total weight of polyalkyl(meth)acrylate. The mixture can be processed to give foamed mouldings. The mouldings can he used in footwear soles, stud material, insulation or insulating material, damping components, lightweight components, or in a sandwich structure.
    Type: Application
    Filed: October 16, 2019
    Publication date: November 17, 2022
    Applicants: Röhm GmbH, Evonik Operations GmbH
    Inventors: Kathrin Salwiczek, Alexander Richter, Christine Weiß, Wolfgang Luley, Andreas Weber, Lukas Friedrich Dössel, David Bailey, Ralf Richter, Steffen Krill, Johannes Vorholz, Maren Kuhn
  • Patent number: 11482956
    Abstract: An arrangement contains an asynchronous machine having a rotor and a stator. The arrangement is set up in a generator mode for feeding electrical energy into an AC voltage network. The arrangement is characterized in that the asynchronous machine can be doubly fed. The asynchronous machine can be connected in a matrix configuration to the AC voltage network by a modular multi-level converter, and the modular multi-level converter is set up in a motor mode of the arrangement for starting up the asynchronous machine while short-circuiting the rotor or the stator.
    Type: Grant
    Filed: December 5, 2017
    Date of Patent: October 25, 2022
    Assignee: Siemens Energy Global GmbH & Co. KG
    Inventors: Friedemann Augsburger, Rainer Gruber, German Kuhn, Alexander Rentschler, Kunal Sharma
  • Patent number: 11477370
    Abstract: The invention relates to a method for reconstructing an output image and/or a sequence of output images from raw image data, wherein, in at least one reconstruction chain between a recording of raw image data by means of an image recording device and a display of the output image and/or the sequence of output images on a display unit, at least one reconstruction step for reconstructing the output image and/or the sequence of output images is carried out, and wherein the result of the at least one reconstruction step is discarded when the result is recognized as invalid with respect to the fulfillment of a verification criterion.
    Type: Grant
    Filed: April 29, 2021
    Date of Patent: October 18, 2022
    Assignee: SCHÖLLY FIBEROPTIC GMBH
    Inventors: Stefan Schröer, Matthias Kühn, Alexander Köhler, Daniel Härter, Joachim Jauss
  • Publication number: 20220273820
    Abstract: Disclosed herein are RNA polynucleotides comprising a 5? Cap, a 5? UTR comprising a cap proximal sequence disclosed herein, and a sequence encoding a payload. Also disclosed herein are compositions and medical preparations comprising the same, and methods of making and using the same.
    Type: Application
    Filed: December 30, 2021
    Publication date: September 1, 2022
    Inventors: Ugur Sahin, Alptekin Güler, Andreas Kuhn, Alexander Muik, Annette Vogel, Kerstin Walzer, Sonja Witzel, Stephanie Hein, Özlem Türeci, Gábor Boros, Azita Josefine Mahiny, Jonas Reinholz, Katalin Karikó
  • Patent number: 11426518
    Abstract: An inventive drug delivery system includes a reservoir that holds a drug to be administered. A drug applicator injects or infuses the drug, and a pump generates a flow of the drug from the reservoir to the drug applicator. A control system has a pressure sensor that measures pressure signals indicative of resistance against the flow of the drug and a processor is in communication with the pressure sensor. The control system detects with the pressure sensor a pressure signal indicative of the resistance against the flow of the drug while the drug is being administered and compares the measured pressure signal to a reference value. The control system also generates display data and provides it to an output device when the measured pressure signal exceeds the reference value. The display data includes a scheduled test reminder for a glucose level test that is communicated to an output device.
    Type: Grant
    Filed: June 5, 2020
    Date of Patent: August 30, 2022
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Alexander Licht, Tobias Kuhn-Ullrich
  • Publication number: 20220262172
    Abstract: A method for detecting tampering in a vehicle includes receiving first data of a first type in a central unit; receiving second data of a second type in the central unit, wherein the first type and the second type are different, and the first data and the second data relate to the operation of the vehicle; and checking the first data and the second data for mutual correspondence.
    Type: Application
    Filed: July 10, 2020
    Publication date: August 18, 2022
    Inventors: Sigmund BECKER, Daniel KRETSCHMANN, Tobias KUHN, Ingrid PREM, Alexander SCHEEL, Alexander SCHLENK, Martin STENGL, Martin WOZNIAK
  • Publication number: 20220249704
    Abstract: Disclosed herein are RNA polynucleotides comprising a 5? Cap, a 5? UTR comprising a cap proximal sequence disclosed herein, and a sequence encoding a payload. Also disclosed herein are compositions and medical preparations comprising the same, and methods of making and using the same.
    Type: Application
    Filed: December 30, 2021
    Publication date: August 11, 2022
    Inventors: Ugur Sahin, Alptekin Güler, Andreas Kuhn, Alexander Muik, Annette Vogel, Kerstin Walzer, Sonja Witzel, Stephanie Hein, Özlem Türeci, Gábor Boros, Azita Josefine Mahiny, Jonas Reinholz, Katalin Karikó
  • Patent number: 11342866
    Abstract: A method for operating a pressure control device in a vehicle, in particular in a motor vehicle, wherein current is supplied by an energy source of the vehicle for operating the pressure control device, as a result of which the pressure control device carries out at least one pressure control function, for which at least two actuators of the pressure control device are actuated, wherein at least one current required at maximum for actuating the actuator is determined for each actuator and current budget management for actuating the actuators and/or for carrying out the pressure control functions is performed by the determined currents required at maximum. In addition, the invention relates to a pressure control device for carrying out the method.
    Type: Grant
    Filed: August 9, 2017
    Date of Patent: May 24, 2022
    Inventors: Sascha Dickten, Alexander Kühn, Aleksandar Stanojkovski, Robert Schmidt, Bartosz Maj
  • Publication number: 20220056189
    Abstract: Disclosed are ion-sensitive polymers and methods for their use for monitoring biological phenomena associated with ion fluxes, as well as organic electrochemical transistors including such polymers.
    Type: Application
    Filed: December 17, 2019
    Publication date: February 24, 2022
    Inventors: Eric CLOUTET, Jochen LANG, Alexander KUHN, Georges HADZIIOANNOU, Matthieu RAOUX, Ariana VILLARROEL, Myriam ABARKAN
  • Publication number: 20210025410
    Abstract: A method for operating a pressure control device in a vehicle, in particular in a motor vehicle, wherein current is supplied by an energy source of the vehicle for operating the pressure control device, as a result of which the pressure control device carries out at least one pressure control function, for which at least two actuators of the pressure control device are actuated, wherein at least one current required at maximum for actuating the actuator is determined for each actuator and current budget management for actuating the actuators and/or for carrying out the pressure control functions is performed by the determined currents required at maximum. In addition, the invention relates to a pressure control device for carrying out the method.
    Type: Application
    Filed: August 9, 2017
    Publication date: January 28, 2021
    Inventors: Sascha Dickten, Alexander Kühn, Aleksandar Stanojkovski, Robert Schmidt, Bartosz Maj
  • Patent number: 10745821
    Abstract: Dissymmetric particles also called Janus particles of micron or submicron size and methods of synthesis of Janus particles by bipolar electrochemistry, based on substrates of isotropic or anisotropic shape. The particles include an electrically conductive substrate having at least a chemically and/or physically modified part by deposit of a layer of electrochemically depositable material, and a non-modified part. The particles are of isotropic shape, and the layer of electrochemically depositable material has a specific shape delimited by a precise contour.
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: August 18, 2020
    Assignees: UNIVERSITE DE BORDEAUX, INSTITUT POLYTECHNIQUE DE BORDEAUX, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Gabriel Michel Pierre Loget, Alexander Kuhn
  • Patent number: 10608238
    Abstract: A miniaturized electrochemical cell and a method for making it are provided. The method includes preparing at least one inner electrode of an electron conducting or semi-conducting material M1; providing a hollow support made of an electrically insulating material M6 and having at least one internal hollow channel; depositing on the external surface of the support a layer of an electrically conducting material M2; forming a template of colloidal particles of an electrically insulating material M3, on the M2 layer; depositing a layer of an electrically conducting material M4 on the M2 layer; depositing a layer L1 of an electron conducting or semi-conducting material M5 on the M4 layer, introducing the at least one inner electrode into the at least one internal hollow channel of the obtained structure; stabilizing the structure at its two open ends with an electrically insulating material M7; and removing M2, M3, M4 and M6 materials.
    Type: Grant
    Filed: June 29, 2016
    Date of Patent: March 31, 2020
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE BORDEAUX, INSTITUT POLYTECHNIQUE BORDEAUX
    Inventors: Nicolas Mano, Stephane Reculusa, Serge Ravaine, Aleksandar Karajic, Alexander Kuhn
  • Publication number: 20190376930
    Abstract: The invention relates to an electrochemical method and device for detecting and/or quantifying sulphur dioxide (S(¾) in its various uncomplexed forms (molecular and ionic) in an aqueous or hydroalcoholic liquid food product. It also relates to a method for regenerating an electrode, the active surface of which is composed of gold. The electrochemical method for detecting and/or quantifying sulphur dioxide (SO2) in its uncomplexed (free) forms in an aqueous or hydroalcoholic liquid food product of the invention comprises: a) introducing into the liquid food product a measuring electrode, the active surface of which, in contact with the liquid food product is entirely made of gold, b) measuring the variation of the current produced by the oxidisation of the free SC½, present in the food liquid, during a potential sweep by cyclic voltammetry. In particular, the invention is used for measuring free S(¾).
    Type: Application
    Filed: February 20, 2018
    Publication date: December 12, 2019
    Applicants: Universite de Bordeaux, Institut Polytechnique de Bordeaux, Centre National de la Recherche Scientifique
    Inventors: Stéphane Arbault, Stéphane Reculusa, Alexander Kuhn, Neso Sojic, Pascal Masse
  • Publication number: 20180205070
    Abstract: A miniaturized electrochemical cell and a method for making it are provided. The method includes preparing at least one inner electrode of an electron conducting or semi-conducting material M1; providing a hollow support made of an electrically insulating material M6 and having at least one internal hollow channel; depositing on the external surface of the support a layer of an electrically conducting material M2; forming a template of colloidal particles of an electrically insulating material M3, on the M2 layer; depositing a layer of an electrically conducting material M4 on the M2 layer; depositing a layer L1 of an electron conducting or semi-conducting material M5 on the M4 layer, introducing the at least one inner electrode into the at least one internal hollow channel of the obtained structure; stabilizing the structure at its two open ends with an electrically insulating material M7; and removing M2, M3, M4 and M6 materials.
    Type: Application
    Filed: June 29, 2016
    Publication date: July 19, 2018
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE BORDEAUX, INSTITUT POLYTECHNIQUE BORDEAUX
    Inventors: Nicolas MANO, Stephane RECULUSA, Serge RAVAINE, Aleksandar KARAJIC, Alexander KUHN
  • Publication number: 20170350816
    Abstract: The present invention relates to a device, comprising at least one layer of an active material having a first optical thickness, the active material being selected so as to experience a change (i) of at least one size dimension, (ii) of the resistance, (iii) of the refractive index or (iv) combinations of two or more of the foregoing, when the active material is subjected to a change in environment, wherein at least one and preferably all of the layers of the at least one layer of the active material is composed of at least two nanosheets of the active material, with the at least two nanosheets randomly overlapping one another. The invention further relates to a nanosheet of active material and to a use of the nanosheet of the material.
    Type: Application
    Filed: November 26, 2015
    Publication date: December 7, 2017
    Inventors: Katalin Szendrei, Pirmin Ganter, Olalla Sanchez-Sobrado, Alexander Kuhn, Bettina Lotsch
  • Publication number: 20170130356
    Abstract: Dissymmetric particles also called Janus particles of micron or submicron size and methods of synthesis of Janus particles by bipolar electrochemistry, based on substrates of isotropic or anisotropic shape. The particles include an electrically conductive substrate having at least a chemically and/or physically modified part by deposit of a layer of electrochemically depositable material, and a non-modified part. The particles are of isotropic shape, and the layer of electrochemically depositable material has a specific shape delimited by a precise contour.
    Type: Application
    Filed: September 16, 2016
    Publication date: May 11, 2017
    Inventors: Gabriel Michel Pierre Loget, Alexander Kuhn
  • Publication number: 20160259918
    Abstract: The present invention relates to a method for identifying a therapeutic drug combination against a cancer, wherein the cancer comprises at least two alterations in at least two different, but crosstalking signaling pathways, the method comprising the steps of: a) providing a kinetic model of a biological network for said cancer comprising the at least two different, but crosstalking signaling pathways, wherein the kinetic model is generated by choosing a network topology, wherein the nodes of said topology represent biological entities selected from the group comprising genes, transcripts, peptides, proteins, protein modification states, small molecules, complexes, metabolites and modifications thereof, and the edges of said topology represent interactions between said entities, assigning kinetic laws and kinetic constants to the interactions and assigning concentrations to the biological entities, such that the kinetic model reflects the genome, epi-genome, proteome and/or transcriptome of said cancer, b)sel
    Type: Application
    Filed: October 6, 2014
    Publication date: September 8, 2016
    Applicant: ALACRIS THERANOSTICS GMBH
    Inventors: Alexander KÜHN, Bodo LANGE, Svetlana PEYCHEVA, Hans LEHRACH, Christoph WIERLING
  • Publication number: 20140030527
    Abstract: Dissymmetric particles also called Janus particles of micron or submicron size and methods of synthesis of Janus particles by bipolar electrochemistry, based on substrates of isotropic or anisotropic shape. The particles include an electrically conductive substrate having at least a chemically and/or physically modified part by deposit of a layer of electrochemically depositable material, and a non-modified part. The particles are of isotropic shape, and the layer of electrochemically depositable material has a specific shape delimited by a precise contour.
    Type: Application
    Filed: December 15, 2011
    Publication date: January 30, 2014
    Applicant: UNIVERSITE BORDEAUX 1
    Inventors: Gabriel Michel Pierre Loget, Alexander Kuhn
  • Publication number: 20130119028
    Abstract: The invention relates to a device for processing pipes or other elongated materials (6) by means of a laser beam (8) produced by a laser beam source (7), comprising a retaining element for retaining a tool or cutting element, wherein said retaining element is mounted so as to be slidable and rotatable relative to a machine bed (1). The material (6) to be processed passes through an opening (5) surrounded by the retaining element. Favorable and flexible processing of widely varying materials is enabled in that the rotatably and slidably mounted retaining element is an elongated rotational element, on the inside of which the laser beam source (7) for the laser beam (8) is arranged as the tool or cutting element.
    Type: Application
    Filed: July 15, 2011
    Publication date: May 16, 2013
    Inventors: Alexander Kuhn, Christoph Deininger