Abstract: A valve assembly for a piston compressor, in particular an oil-free piston compressor for generating compressed air in a rail vehicle, includes a valve plate having a compressed-air opening, a valve retainer and a valve lamina which is flexible and/or movable in relation to the valve retainer and is provided for opening and closing the compressed-air opening; wherein a damping and/or braking device is provided which is associated with the valve lamina.

Abstract: This disclosure relates to the field of RNA to prevent or treat coronavirus infection. In particular, the present disclosure relates to methods and agents for vaccination against coronavirus infection and inducing effective coronavirus antigen-specific immune responses such as antibody and/or T cell responses. Specifically, in one embodiment, the present disclosure relates to methods comprising administering to a subject RNA encoding a peptide or protein comprising an epitope of SARS-CoV-2 spike protein (S protein) for inducing an immune response against coronavirus S protein, in particular S protein of SARS-CoV-2, in the subject. i.e., vaccine RNA encoding vaccine antigen.

Abstract: This disclosure relates to the field of RNA to prevent or treat coronavirus infection. In particular, the present disclosure relates to methods and agents for vaccination against coronavirus infection and inducing effective coronavirus antigen-specific immune responses such as antibody and/or T cell responses. Specifically, in one embodiment, the present disclosure relates to methods comprising administering to a subject RNA encoding a peptide or protein comprising an epitope of SARS-CoV-2 spike protein (S protein) for inducing an immune response against coronavirus S protein, in particular S protein of SARS-CoV-2, in the subject, i.e., vaccine RNA encoding vaccine antigen.

Abstract: The present disclosure provides a screw and a screw assemblage. The screw includes a screw head and a screw shaft which protrudes from an underside of the screw head and has a self-forming or self-cutting thread, wherein the underside of the screw head has a bearing area and at least one annular recess extending around the shaft between the bearing area and the shaft, wherein a coating made of an elastic sealant is attached to the underside of the screw head.

Abstract: The present disclosure provides a screw and a screw assemblage. The screw includes a screw head and a screw shaft which protrudes from an underside of the screw head and has a self-forming or self-cutting thread, wherein the underside of the screw head has a bearing area and at least one annular recess extending around the shaft between the bearing area and the shaft, wherein a coating made of an elastic sealant is attached to the underside of the screw head.

Abstract: A method for operating a pressure control device in a vehicle, in particular in a motor vehicle, wherein current is supplied by an energy source of the vehicle for operating the pressure control device, as a result of which the pressure control device carries out at least one pressure control function, for which at least two actuators of the pressure control device are actuated, wherein at least one current required at maximum for actuating the actuator is determined for each actuator and current budget management for actuating the actuators and/or for carrying out the pressure control functions is performed by the determined currents required at maximum. In addition, the invention relates to a pressure control device for carrying out the method.

Abstract: Disclosed are ion-sensitive polymers and methods for their use for monitoring biological phenomena associated with ion fluxes, as well as organic electrochemical transistors including such polymers.

Abstract: A method for operating a pressure control device in a vehicle, in particular in a motor vehicle, wherein current is supplied by an energy source of the vehicle for operating the pressure control device, as a result of which the pressure control device carries out at least one pressure control function, for which at least two actuators of the pressure control device are actuated, wherein at least one current required at maximum for actuating the actuator is determined for each actuator and current budget management for actuating the actuators and/or for carrying out the pressure control functions is performed by the determined currents required at maximum. In addition, the invention relates to a pressure control device for carrying out the method.

Abstract: Dissymmetric particles also called Janus particles of micron or submicron size and methods of synthesis of Janus particles by bipolar electrochemistry, based on substrates of isotropic or anisotropic shape. The particles include an electrically conductive substrate having at least a chemically and/or physically modified part by deposit of a layer of electrochemically depositable material, and a non-modified part. The particles are of isotropic shape, and the layer of electrochemically depositable material has a specific shape delimited by a precise contour.

Abstract: A miniaturized electrochemical cell and a method for making it are provided. The method includes preparing at least one inner electrode of an electron conducting or semi-conducting material M1; providing a hollow support made of an electrically insulating material M6 and having at least one internal hollow channel; depositing on the external surface of the support a layer of an electrically conducting material M2; forming a template of colloidal particles of an electrically insulating material M3, on the M2 layer; depositing a layer of an electrically conducting material M4 on the M2 layer; depositing a layer L1 of an electron conducting or semi-conducting material M5 on the M4 layer, introducing the at least one inner electrode into the at least one internal hollow channel of the obtained structure; stabilizing the structure at its two open ends with an electrically insulating material M7; and removing M2, M3, M4 and M6 materials.

Abstract: The invention relates to an electrochemical method and device for detecting and/or quantifying sulphur dioxide (S(¾) in its various uncomplexed forms (molecular and ionic) in an aqueous or hydroalcoholic liquid food product. It also relates to a method for regenerating an electrode, the active surface of which is composed of gold. The electrochemical method for detecting and/or quantifying sulphur dioxide (SO2) in its uncomplexed (free) forms in an aqueous or hydroalcoholic liquid food product of the invention comprises: a) introducing into the liquid food product a measuring electrode, the active surface of which, in contact with the liquid food product is entirely made of gold, b) measuring the variation of the current produced by the oxidisation of the free SC½, present in the food liquid, during a potential sweep by cyclic voltammetry. In particular, the invention is used for measuring free S(¾).

Abstract: A miniaturized electrochemical cell and a method for making it are provided. The method includes preparing at least one inner electrode of an electron conducting or semi-conducting material M1; providing a hollow support made of an electrically insulating material M6 and having at least one internal hollow channel; depositing on the external surface of the support a layer of an electrically conducting material M2; forming a template of colloidal particles of an electrically insulating material M3, on the M2 layer; depositing a layer of an electrically conducting material M4 on the M2 layer; depositing a layer L1 of an electron conducting or semi-conducting material M5 on the M4 layer, introducing the at least one inner electrode into the at least one internal hollow channel of the obtained structure; stabilizing the structure at its two open ends with an electrically insulating material M7; and removing M2, M3, M4 and M6 materials.

Abstract: The present invention relates to a device, comprising at least one layer of an active material having a first optical thickness, the active material being selected so as to experience a change (i) of at least one size dimension, (ii) of the resistance, (iii) of the refractive index or (iv) combinations of two or more of the foregoing, when the active material is subjected to a change in environment, wherein at least one and preferably all of the layers of the at least one layer of the active material is composed of at least two nanosheets of the active material, with the at least two nanosheets randomly overlapping one another. The invention further relates to a nanosheet of active material and to a use of the nanosheet of the material.

Abstract: Dissymmetric particles also called Janus particles of micron or submicron size and methods of synthesis of Janus particles by bipolar electrochemistry, based on substrates of isotropic or anisotropic shape. The particles include an electrically conductive substrate having at least a chemically and/or physically modified part by deposit of a layer of electrochemically depositable material, and a non-modified part. The particles are of isotropic shape, and the layer of electrochemically depositable material has a specific shape delimited by a precise contour.

Abstract: The present invention relates to a method for identifying a therapeutic drug combination against a cancer, wherein the cancer comprises at least two alterations in at least two different, but crosstalking signaling pathways, the method comprising the steps of: a) providing a kinetic model of a biological network for said cancer comprising the at least two different, but crosstalking signaling pathways, wherein the kinetic model is generated by choosing a network topology, wherein the nodes of said topology represent biological entities selected from the group comprising genes, transcripts, peptides, proteins, protein modification states, small molecules, complexes, metabolites and modifications thereof, and the edges of said topology represent interactions between said entities, assigning kinetic laws and kinetic constants to the interactions and assigning concentrations to the biological entities, such that the kinetic model reflects the genome, epi-genome, proteome and/or transcriptome of said cancer, b)sel

Abstract: Dissymmetric particles also called Janus particles of micron or submicron size and methods of synthesis of Janus particles by bipolar electrochemistry, based on substrates of isotropic or anisotropic shape. The particles include an electrically conductive substrate having at least a chemically and/or physically modified part by deposit of a layer of electrochemically depositable material, and a non-modified part. The particles are of isotropic shape, and the layer of electrochemically depositable material has a specific shape delimited by a precise contour.

Abstract: The invention relates to a device for processing pipes or other elongated materials (6) by means of a laser beam (8) produced by a laser beam source (7), comprising a retaining element for retaining a tool or cutting element, wherein said retaining element is mounted so as to be slidable and rotatable relative to a machine bed (1). The material (6) to be processed passes through an opening (5) surrounded by the retaining element. Favorable and flexible processing of widely varying materials is enabled in that the rotatably and slidably mounted retaining element is an elongated rotational element, on the inside of which the laser beam source (7) for the laser beam (8) is arranged as the tool or cutting element.

Abstract: This invention relates to the field of signal transit time sensors, in particular sensors based on ultrasonic transit times. Existing electronic control circuits for such transit time sensors for measurements on medical liquids, in particular blood, are extremely complex or their time resolution is limited. However, the present invention makes use of a simple measurement technique which cannot be used directly at first for the time resolution to be achieved. In this method, an ordinary sampling method is used to detect the received signal (12). An oscillator-like received signal (12) generated by an emitted step-like signal is first sampled during a half-period (14, 15) and is checked with the help of a selection criterion.

Abstract: This invention relates to the field of signal transit time sensors, in particular sensors based on ultrasonic transit times. Existing electronic control circuits for such transit time sensors for measurements on medical liquids, in particular blood, are extremely complex or their time resolution is limited. However, the present invention makes use of a simple measurement technique which cannot be used directly at first for the time resolution to be achieved. In this method, an ordinary sampling method is used to detect the received signal (12). An oscillator-like received signal (12) generated by an emitted step-like signal is first sampled during a half-period (14, 15) and is checked with the help of a selection criterion.

Abstract: A device for articulated connection between a control element and a control rod having a ball head comprising a main body attachable to the control element. The main body envelops a locating section providing positive location for the ball head and has an opening area through which the control rod extends when the device is assembled. According to the invention, the locating section is in two parts whereby the main body forms a part into which the ball head can be introduced through a joint duct located outside the opening, while a molding insertable into the joint duct forms the other part of the locating section. As a result, a simple device is created, guaranteeing connection between the control element and the control rod which is backlash-free or has little backlash.