Patents by Inventor Alexander Laurence MANDEL

Alexander Laurence MANDEL has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CYTOTOXIC AND ANTI-MITOTIC COMPOUNDS, AND METHODS OF USING THE SAME
    Publication number: 20230390354
    Abstract: Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.
    Type: Application
    Filed: February 21, 2023
    Publication date: December 7, 2023
    Applicant: ZYMEWORKS BC INC.
    Inventors: Geoffrey C. WINTERS, Alexander Laurence MANDEL, James R. RICH, Bradley John HEDBERG, Tom Han Hsiao HSIEH, Elyse Marie Josée BOURQUE, John BABCOOK
  • CYTOTOXIC AND ANTI-MITOTIC COMPOUNDS, AND METHODS OF USING THE SAME
    Publication number: 20230317700
    Abstract: Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.
    Type: Application
    Filed: January 20, 2023
    Publication date: October 5, 2023
    Inventors: Geoffrey C. WINTERS, James R. RICH, Graham Albert Edwin GARNETT, Alexander Laurence MANDEL, Tom Han Hsiao HSIEH, Elyse Marie Josée BOURQUE, Stuart Daniel BARNSCHER
  • Cytotoxic and anti-mitotic compounds, and methods of using the same
    Patent number: 11617777
    Abstract: Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.
    Type: Grant
    Filed: February 11, 2019
    Date of Patent: April 4, 2023
    Inventors: Geoffrey C. Winters, Alexander Laurence Mandel, James R. Rich, Bradley John Hedberg, Tom Han Hsiao Hsieh, Elyse Marie Josée Bourque, John Babcook
  • Cytotoxic and anti-mitotic compounds, and methods of using the same
    Patent number: 11591405
    Abstract: Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.
    Type: Grant
    Filed: July 26, 2019
    Date of Patent: February 28, 2023
    Inventors: Geoffrey C. Winters, James R. Rich, Graham Albert Edwin Garnett, Alexander Laurence Mandel, Tom Han Hsiao Hsieh, Elyse Marie Josée Bourque, Stuart Daniel Barnscher
  • CYTOTOXIC AND ANTI-MITOTIC COMPOUNDS, AND METHODS OF USING THE SAME
    Publication number: 20190345254
    Abstract: Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.
    Type: Application
    Filed: July 26, 2019
    Publication date: November 14, 2019
    Inventors: Geoffrey C. WINTERS, James R. RICH, Graham Albert Edwin GARNETT, Alexander Laurence MANDEL, Tom Han Hsiao HSIEH, Elyse Marie Josée BOURQUE, Stuart Daniel BARNSCHER
  • Cytotoxic and anti-mitotic compounds, and methods of using the same
    Patent number: 10450378
    Abstract: Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.
    Type: Grant
    Filed: September 17, 2015
    Date of Patent: October 22, 2019
    Assignee: ZYMEWORKS INC.
    Inventors: Geoffrey C. Winters, James R. Rich, Graham Albert Edwin Garnett, Alexander Laurence Mandel, Tom Han Hsiao Hsieh, Elyse Marie Josee Bourque, Stuart Daniel Barnscher
  • Cytotoxic and anti-mitotic compounds, and methods of using the same
    Patent number: 10414822
    Abstract: Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.
    Type: Grant
    Filed: January 16, 2018
    Date of Patent: September 17, 2019
    Assignee: ZYMEWORKS INC.
    Inventors: Geoffrey C. Winters, James R. Rich, Graham Albert Edwin Garnett, Alexander Laurence Mandel, Tom Han Hsiao Hsieh, Elyse Marie Josée Bourque, Stuart Daniel Barnscher
  • CYTOTOXIC AND ANTI-MITOTIC COMPOUNDS, AND METHODS OF USING THE SAME
    Publication number: 20190269785
    Abstract: Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.
    Type: Application
    Filed: February 11, 2019
    Publication date: September 5, 2019
    Inventors: Geoffrey C. WINTERS, Alexander Laurence MANDEL, James R. RICH, Bradley John HEDBERG, Tom Han Hsiao HSIEH, Elyse Marie Josée BOURQUE, John BABCOOK
  • Cytotoxic and anti-mitotic compounds, and methods of using the same
    Patent number: 10201614
    Abstract: Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: February 12, 2019
    Assignee: ZYMEWORKS INC.
    Inventors: Geoffrey C. Winters, Alexander Laurence Mandel, James R. Rich, Bradley John Hedberg, Tom Han Hsiao Hsieh, Elyse Marie Josée Bourque, John Babcook
  • Antibiotic Compounds, Pharmaceutical Formulations Thereof And Methods And Uses Therefor
    Publication number: 20180312493
    Abstract: The present invention relates to compounds of formula (I) wherein G1 to G8 are as defined herein. The compounds are PK inhibitors and as such represent a new approach to treating pathogenic infections, including multidrug resistant pathogens. Disclosed herein are the compounds of formula (I), pharmaceutical compositions comprising the compounds of formula (I) and their use in the treatment of antimicrobial infection.
    Type: Application
    Filed: November 4, 2016
    Publication date: November 1, 2018
    Inventors: Robert Norman Young, Nag Sharwan Kumar, Alexander Laurence Mandel, Tom Han Hsiao Hsieh, Jason Samuel Tan, Fahimeh S. Shidmoossavee, James Brian Jaquith, Edith Mary Dullaghan
  • CYTOTOXIC AND ANTI-MITOTIC COMPOUNDS, AND METHODS OF USING THE SAME
    Publication number: 20180208667
    Abstract: Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.
    Type: Application
    Filed: January 16, 2018
    Publication date: July 26, 2018
    Inventors: Geoffrey C. WINTERS, James R. RICH, Graham Albert Edwin GARNETT, Alexander Laurence MANDEL, Tom Han Hsiao HSIEH, Elyse Marie Josée BOURQUE, Stuart Daniel BARNSCHER
  • Cytotoxic and anti-mitotic compounds, and methods of using the same
    Patent number: 9879086
    Abstract: Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.
    Type: Grant
    Filed: September 17, 2015
    Date of Patent: January 30, 2018
    Assignee: ZYMEWORKS INC.
    Inventors: Geoffrey C. Winters, James R. Rich, Graham Albert Edwin Garnett, Alexander Laurence Mandel, Tom Han Hsiao Hsieh, Elyse Marie Josée Bourque, Stuart Daniel Barnscher
  • CYTOTOXIC AND ANTI-MITOTIC COMPOUNDS, AND METHODS OF USING THE SAME
    Publication number: 20170247408
    Abstract: Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.
    Type: Application
    Filed: September 17, 2015
    Publication date: August 31, 2017
    Inventors: Geoffrey C. WINTERS, James R. RICH, Graham Albert Edwin GARNETT, Alexander Laurence MANDEL, Tom Han Hsiao HSIEH, Elyse Marie Josee BOURQUE, Stuart Daniel BARNSCHER
  • CYTOTOXIC AND ANTI-MITOTIC COMPOUNDS, AND METHODS OF USING THE SAME
    Publication number: 20160075735
    Abstract: Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.
    Type: Application
    Filed: September 17, 2015
    Publication date: March 17, 2016
    Inventors: Geoffrey C. WINTERS, James R. RICH, Graham Albert Edwin GARNETT, Alexander Laurence MANDEL, Tom Han Hsiao HSIEH, Elyse Marie Josée BOURQUE, Stuart Daniel BARNSCHER
  • CYTOTOXIC AND ANTI-MITOTIC COMPOUNDS, AND METHODS OF USING THE SAME
    Publication number: 20160038606
    Abstract: Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.
    Type: Application
    Filed: March 14, 2014
    Publication date: February 11, 2016
    Inventors: Geoffrey C. WINTERS, Alexander Laurence MANDEL, James R. RICH, Bradley John HEDBERG, Tom Han Hsiao HSIEH, Elyse Marie Josée BOURQUE, John BABCOOK