Abstract: Disclosed are methods for inhibiting proliferation of a cell or inducing apoptosis. In general, the methods include the steps of providing an elevated level of M6P/IGF2R protein in the cell, and contacting the cell with a compound, e.g., a retinoid, that binds to the M6P/IGF2R protein. The methods can be used to inhibit proliferation of a cancer cell or induce apoptosis in a cancer cell. Also disclosed is a method for potentiating an M6P/IGF2R-mediated effect in a cell. Also disclosed are screening methods for identification of compounds that bind directly to the retinoic acid binding site of a M6P/IGF2R protein.

Abstract: Methods and compositions for the prevention of imminent ventricular fibrillation are disclosed. The composition comprises eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), or a mixture of EPA and DHA. The composition may be administered by intravenous infusion, intracardial injection or both in a patient who presents symptoms of a condition, such as myocardial infarction, which may immediately lead to ventricular fibrillation.

Abstract: Disclosed is a method for terminating an existing potentially lethal cardiac arrhythmia, or preventing an imminent potentially lethal cardiac arrhythmia. The method involves administration of all-trans-retinoic acid or an antiarrhythmically active analog. Antiarrhythmic effects of all-trans-retinoic acid occur within minutes.

Abstract: Methods and compositions for the prevention of imminent ventricular tachyarrhythmia, particularly ventricular fibrillation, are disclosed. The composition comprises .alpha.-linolenic acid, eicosatetraynoic acid (ETYA), or a mixture of .alpha.-linolenic acid and ETYA. The composition may be administered by intravenous infusion, intracardial injection or both in a patient who presents symptoms of a condition, such as myocardial ischemia associated with myocardial infarction, which may immediately lead to ventricular fibrillation.