Patents by Inventor Alexander Lee Satz

Alexander Lee Satz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SMALL MOLECULE SCREENING CELLULAR ASSAY USING MODIFIED BEADS
    Publication number: 20220213471
    Abstract: A method for screening a DNA-encoded library of chemical structures (2) for activity in a cellular target (11) wherein the chemical structures (2) of the library, the corresponding encoding DNA (4) and, optionally, a chemical probe (7/8/9) susceptible to the response molecule (12) are covalently linked to beads (1); the method comprising providing an incubation medium (13) or aliquot thereof comprising the cellular target (11) and exactly one or more than one bead (1) as defined above, releasing the chemical structures (2) from the bead(s) (1) in the incubation medium (13) or aliquots thereof by cleaving the structure linkers (3) and incubating the released chemical structures (2) and the cellular target (11); and sequencing the encoding DNA present or remaining on the bead(s) (1). A bead (1) suited for the method is also provided.
    Type: Application
    Filed: April 15, 2020
    Publication date: July 7, 2022
    Inventors: Alexander Lee SATZ, Gregor DERNICK, Claudio ZAMBALDO
  • BICYCLIC QUINAZOLINONE DERIVATIVES
    Publication number: 20200317624
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R12, R13, R14, A1, A2, A3, n and m are as described herein.
    Type: Application
    Filed: February 18, 2020
    Publication date: October 8, 2020
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Jerome HERT, Daniel HUNZIKER, Christoph KURATLI, Rainer E. MARTIN, Patrizio MATTEI, Alexander Lee SATZ
  • Bicyclic quinazolinone derivatives
    Patent number: 10676446
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R12, R13, R14, A1, A2, A3, n and m are as described herein.
    Type: Grant
    Filed: October 10, 2017
    Date of Patent: June 9, 2020
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jerome Hert, Daniel Hunziker, Christoph Kuratli, Rainer E. Martin, Patrizio Mattei, Alexander Lee Satz
  • Triaza-spirodecanones as DDR1 inhibitors
    Patent number: 10435407
    Abstract: The present invention relates to compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein L and R1 to R5 are as described herein, as well as processes for their manufacture, pharmaceutical compositions comprising them, and their use as medicaments.
    Type: Grant
    Filed: February 4, 2019
    Date of Patent: October 8, 2019
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Bernd Buettelmann, Buelent Kocer, Bernd Kuhn, Marco Prunotto, Hans Richter, Martin Ritter, Markus Rudolph, Alexander Lee Satz
  • TRIAZA-SPIRODECANONES AS DDR1 INHIBITORS
    Publication number: 20190169189
    Abstract: The present invention relates to compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein L and R1 to R5 are as described herein, as well as processes for their manufacture, pharmaceutical compositions comprising them, and their use as medicaments.
    Type: Application
    Filed: February 4, 2019
    Publication date: June 6, 2019
    Applicant: Hoffmann-La Roche Inc.
    Inventors: BERND BUETTELMANN, BUELENT KOCER, BERND KUHN, MARCO PRUNOTTO, HANS RICHTER, MARTIN RITTER, MARKUS RUDOLPH, ALEXANDER LEE SATZ
  • Triaza-spirodecanones as DDR1 inhibitors
    Patent number: 10239876
    Abstract: The present invention relates to compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein L and R1 to R5 are as described herein, as well as processes for their manufacture, pharmaceutical compositions comprising them, and their use as medicaments.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: March 26, 2019
    Assignee: Hoffman La-Roche Inc.
    Inventors: Bernd Buettelmann, Buelent Kocer, Bernd Kuhn, Marco Prunotto, Hans Richter, Martin Ritter, Markus Rudolph, Alexander Lee Satz
  • TRIAZA-SPIRODECANONES AS DDR1 INHIBITORS
    Publication number: 20180148450
    Abstract: The present invention relates to compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein L and R1 to R5 are as described herein, as well as processes for their manufacture, pharmaceutical compositions comprising them, and their use as medicaments.
    Type: Application
    Filed: December 21, 2017
    Publication date: May 31, 2018
    Applicant: Hoffmann La-Roche Inc.
    Inventors: Bernd BUETTELMANN, Buelent KOCER, Bernd KUHN, Marco PRUNOTTO, Hans RICHTER, Martin RITTER, Markus RUDOLPH, Alexander Lee SATZ
  • BICYCLIC QUINAZOLINONE DERIVATIVES
    Publication number: 20180029996
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R12, R13, R14, A1, A2, A3, n and m are as described herein.
    Type: Application
    Filed: October 10, 2017
    Publication date: February 1, 2018
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Jerome Hert, Daniel Hunziker, Christoph Kuratli, Rainer E. Martin, Patrizio Mattei, Alexander Lee Satz