Abstract: A method for operating an air guiding device of a motor vehicle includes adjusting an air guiding element of the air guiding device from a starting position into an active position which influences aerodynamics of the motor vehicle. The method further includes exerting feedback pertaining to the adjusting of the air guiding element on a motor vehicle occupant in a form of a relative movement acting on the motor vehicle occupant, where the relative movement is generated by an adjustment of a chassis and/or a seat system of the motor vehicle from a first position to a second position.

Abstract: Systems and methods for generating a preview stream for a user of a video conferencing service. In some aspects, the systems and methods provide for receiving a video stream of at least a portion of a display screen of a user device and determining whether the user device has been designated as a receiving device for receiving a version of the video stream. In response to determining that the user device has not been designated as a receiving device for receiving a version of the video stream, a request is generated to designate the user device as a receiving device in addition to being a presenting device. Based on images of the video stream, a preview stream (e.g., of at least a portion of the display screen) is generated and transmitted for display at the user device.

Abstract: A rear derailleur is configured as a hierarchical, at least two-level modular construction system and comprises at least several of the modules: “base element module”, “swivel formation module”, “shifting element module”, and “chain guiding device module”. At least one of the modules is replaceable and handleable in one piece. At least one of the modules includes at least one sub-assembly that is replaceable and handleable in one piece. In an embodiment the modular construction system is configured to use at least one family of sub-assemblies comprising at least two family members within at least one of the modules.

Abstract: Systems and methods for generating a preview stream for a user of a video conferencing service. In some aspects, the systems and methods provide for receiving a video stream of at least a portion of a display screen of a user device and determining whether the user device has been designated as a receiving device for receiving a version of the video stream. In response to determining that the user device has not been designated as a receiving device for receiving a version of the video stream, a request is generated to designate the user device as a receiving device in addition to being a presenting device. Based on images of the video stream, a preview stream (e.g., of at least a portion of the display screen) is generated and transmitted for display at the user device.

Abstract: This disclosure relates to multispecific recombinant proteins useful for the treatment of cancer.

Abstract: Systems and methods for generating a preview stream for a user of a video conferencing service. In some aspects, the systems and methods provide for receiving a video stream of at least a portion of a display screen of a user device and determining whether the user device has been designated as a receiving device for receiving a version of the video stream. In response to determining that the user device has not been designated as a receiving device for receiving a version of the video stream, a request is generated to designate the user device as a receiving device in addition to being a presenting device. Based on images of the video stream, a preview stream (e.g., of at least a portion of the display screen) is generated and transmitted for display at the user device.

Abstract: A method for operating an air guiding device of a motor vehicle includes adjusting an air guiding element of the air guiding device from a starting position into an active position which influences aerodynamics of the motor vehicle. The method further includes exerting feedback pertaining to the adjusting of the air guiding element on a motor vehicle occupant in a form of a relative movement acting on the motor vehicle occupant, where the relative movement is generated by an adjustment of a chassis and/or a seat system of the motor vehicle from a first position to a second position.

Abstract: A bicycle operating apparatus for wirelessly controlling at least one component of a bicycle includes a carrier element on a fastening device for fixing the bicycle operating apparatus to a handlebar of the bicycle, a housing attachable to the carrier element having an energy storage compartment for receiving an energy storage element and having an electronic circuit arrangement in the housing. At least one switch is connected to the electronic circuit arrangement on the housing. An operating component mounted on the carrier element to be pivotable about an operating axis preloaded into a neutral position which is able to be deflected out of the neutral position in a first direction of rotation about the operating axis in order to actuate the switch, and the operating axis extends obliquely with respect to the flat outer surface.

Abstract: The present disclosure relates to recombinant binding proteins comprising a designed ankyrin repeat domain with binding specificity for 4-1 BB (CD 137). In addition, the disclosure relates to nucleic acids encoding such binding proteins, pharmaceutical compositions comprising such binding proteins or nucleic acids, and the use of such binding proteins, nucleic acids or pharmaceutical compositions in methods for activating 4-1 BB in cells expressing 4-1 BB, e.g., tumor-localized T-lymphocytes, and for treating or diagnosing diseases, such as cancer, in a mammal, including a human.

Abstract: A control device for a bicycle is arranged or can be arranged on the handlebar of the bicycle and serves to wirelessly drive at least one electronic, electrical, electromechanical or electrohydraulic component of the bicycle. The control device includes an operator control arrangement which has at least one manually operable operator control element and is designed to respond to operation of the operator control element and to output electrical signals which represent the operation. The control device also includes at least one electronic circuit arrangement comprising a radio communication circuit and a control circuit which is connected or can be connected to the operator control arrangement. The control device also may include at least one antenna which is connected or can be connected to the radio communication circuit or which is integrated into the said communication circuit.

Abstract: A control device for a bicycle is arranged or can be arranged on the handlebar of the bicycle and serves to wirelessly drive at least one electronic, electrical, electromechanical or electrohydraulic component of the bicycle. The control device includes an operator control arrangement which has at least one manually operable operator control element and is designed to respond to operation of the operator control element and to output electrical signals which represent the operation. The control device also includes at least one electronic circuit arrangement comprising a radio communication circuit and a control circuit which is connected or can be connected to the operator control arrangement. The control device also may include at least one antenna which is connected or can be connected to the radio communication circuit or which is integrated into the said communication circuit.

Abstract: A bicycle operating apparatus includes a carrier element having fastening device for fixing the apparatus to the handlebar; a housing, on the carrier element, having an electronic circuit arrangement in the housing; a first and a second switch, each connected to the electronic circuit arrangement, are on the housing; and an operating component mounted on the carrier element pivotable about an operating axis preloaded into a neutral position, the operating component deflected out of the neutral position in a first direction of rotation about the operating axis to actuate the first switch, and deflected out of the neutral position in a second direction opposite to the first direction to actuate the second switch, where the operating component includes a first operating element and a second operating element that are formed separately from one another in one piece and are mounted on the carrier element pivotable about the operating axis.

Abstract: A control device for a bicycle is arranged or can be arranged on the handlebar of the bicycle and serves to wirelessly drive at least one electronic, electrical, electromechanical or electrohydraulic component of the bicycle. The control device includes an operator control arrangement which has at least one manually operable operator control element and is designed to respond to operation of the operator control element and to output electrical signals which represent the operation. The control device also includes at least one electronic circuit arrangement comprising a radio communication circuit and a control circuit which is connected or can be connected to the operator control arrangement. The control device also may include at least one antenna which is connected or can be connected to the radio communication circuit or which is integrated into the said communication circuit.

Abstract: This disclosure relates to multispecific recombinant proteins useful for the treatment of cancer.

Abstract: A control device for a bicycle is arranged or can be arranged on the handlebar of the bicycle and serves to wirelessly drive at least one electronic, electrical, electromechanical or electrohydraulic component of the bicycle. The control device includes an operator control arrangement which has at least one manually operable operator control element and is designed to respond to operation of the operator control element and to output electrical signals which represent the operation. The control device also includes at least one electronic circuit arrangement comprising a radio communication circuit and a control circuit which is connected or can be connected to the operator control arrangement. The control device also may include at least one antenna which is connected or can be connected to the radio communication circuit or which is integrated into the said communication circuit.

Abstract: A control device for a bicycle is arranged or can be arranged on the handlebar of the bicycle and serves to wirelessly drive at least one electronic, electrical, electromechanical or electrohydraulic component of the bicycle. The control device includes an operator control arrangement which has at least one manually operable operator control element and is designed to respond to operation of the operator control element and to output electrical signals which represent the operation. The control device also includes at least one electronic circuit arrangement comprising a radio communication circuit and a control circuit which is connected or can be connected to the operator control arrangement. The control device also may include at least one antenna which is connected or can be connected to the radio communication circuit or which is integrated into the said communication circuit.

Abstract: A control device for a bicycle is arranged or can be arranged on the handlebar of the bicycle and serves to wirelessly drive at least one electronic, electrical, electromechanical or electrohydraulic component of the bicycle. The control device includes an operator control arrangement which has at least one manually operable operator control element and is designed to respond to operation of the operator control element and to output electrical signals which represent the operation. The control device also includes at least one electronic circuit arrangement comprising a radio communication circuit and a control circuit which is connected or can be connected to the operator control arrangement. The control device also may include at least one antenna which is connected or can be connected to the radio communication circuit or which is integrated into the said communication circuit.

Abstract: A simple, rapid, inexpensive, and promising commercial biomarker assay method for multiple diseases is described herein. The present invention detects miRNA-based biomarkers in human stool specimens. The method of the present invention amplifies miRNA directly from stool specimens without any prior miRNA extraction. Differential expression of specific microRNAs in stool of colorectal cancer CRC and adenoma patients suggest fecal microRNAs as a novel potential biomarker for colorectal neoplasia detection. The method of the present invention has diagnostic, prognostic, and therapeutic relevance for gastroenterological cancers/colorectal cancer and as well as further acquired or hereditary GI diseases.

Abstract: A method for sealing a housing includes providing a base plate of the housing with at least one opening; providing an electrical connection that extends through the base plate from an inner side to an outer side of the base plate; and applying a sealing compound into the opening from an outer side of the base plate in order to seal an interface between the base plate and the electrical connection.

Abstract: A simple, rapid, inexpensive, and promising commercial biomarker assay method for multiple diseases is described herein. The present invention detects miRNA-based biomarkers in human stool specimens. The method of the present invention amplifies miRNA directly from stool specimens without any prior miRNA extraction. Differential expression of specific microRNAs in stool of colorectal cancer CRC and adenoma patients suggest fecal microRNAs as a novel potential biomarker for colorectal neoplasia detection. The method of the present invention has diagnostic, prognostic, and therapeutic relevance for gastroenterological cancers/colorectal cancer and as well as further acquired or hereditary GI diseases.