Patents by Inventor Alexander Ludwig

Alexander Ludwig has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10307930
    Abstract: A guide bar for a saw chain includes an elongate, flat base body made of a basic material. The base body extends along a longitudinal center axis and, in order to guide a saw chain, has a running surface formed on an outer periphery thereof and a guide groove formed in the outer periphery of the base body. The guide groove has a groove base. A direction-reversing section for the saw chain is provided at one end of the base body. The direction-reversing section includes at least one add-on component having a running surface made of more wear-resistant material than the basic material of the base body. The add-on component is secured to the base body of the guide bar by at least one weld seam. The weld seam extends between the add-on component and the base body and is located spatially beneath the groove base.
    Type: Grant
    Filed: August 21, 2014
    Date of Patent: June 4, 2019
    Assignee: Andreas Stihl AG & Co. KG
    Inventors: Alexander Fuchs, Thomas Voigt, David Mitrega, Matthias Schulz, Thomas Lux, Oliver Gerstenberger, Jochen Buchholtz, Berthold Schell, Norbert Apfel, Bernd Hein, Ruediger Ludwig, Jan Foehrenbach
  • Patent number: 9611290
    Abstract: The invention provides compounds that are effective as inhibitors of human plasmin and plasma kallikrein, and that are useful for the prevention of blood loss and as components of fibrin adhesives. The invention further provides methods of making and using the compounds.
    Type: Grant
    Filed: October 31, 2013
    Date of Patent: April 4, 2017
    Assignee: THE MEDICINES COMPANY (LEIPZIG) GMBH
    Inventors: Peter Herold, Mohammed Daghish, Stjepan Jelakovic, Friedrich-Alexander Ludwig, Claudia Reichelt, Alexander Schulze, Andrea Schweinitz
  • Publication number: 20150065622
    Abstract: Thermoplastic molding compositions comprising the following components: a) 3 to 91.7 wt % of at least one aromatic polycarbonate, as component A b) 3 to 91.7 wt % of one or more styrene copolymers, as component B c) 3 to 91.7 wt % of one or more impact-modifying grafted rubbers without olefinic double bonding in the rubber plase, as component C, and also d) 0.2 to 0.9 wt % of a compound of formula (I), as component D: e) 0 to 0.9 wt % of a mixture of formula (II), as component E: n=2 to 20 f) 0 to 0.9 wt % of a triazine stabilizer, and also, optionally further components, with the proviso that when component E amounts to 0 wt %, at least one further stabilizer is present in an amount of 0.01 to 0.9 wt %, have good weathering properties.
    Type: Application
    Filed: September 3, 2012
    Publication date: March 5, 2015
    Applicant: STYROLUTION GMBH
    Inventors: Rolf Minkwitz, Alexander Ludwig, Kerim Wewer, Rainer Huebner
  • Publication number: 20140073573
    Abstract: The invention provides compounds that are effective as inhibitors of human plasmin and plasma kallikrein, and that are useful for the prevention of blood loss and as components of fibrin adhesives. The invention further provides methods of making and using the compounds.
    Type: Application
    Filed: October 31, 2013
    Publication date: March 13, 2014
    Applicant: THE MEDICINES COMPANY (LEIPZIG) GMBH
    Inventors: Peter HEROLD, Mohammed DAGHISH, Stjepan JELAKOVIC, Friedrich-Alexander LUDWIG, Claudia REICHELT, Alexander SCHULZE, Andrea SCHWEINITZ
  • Patent number: 8664233
    Abstract: The invention relates to compounds of general formula 1 to processes for the production thereof, to pharmaceutical preparations containing said compounds and/or physiologically compatible salts and/or solvates which can be produced therefrom as well as to the pharmaceutical use of said compounds, the salts or solvates thereof as inductors of apoptosis in the case of non-solid malignant tumors of the hematopoietic system, in particular in the case of leukemias and lymphomas, more particularly in the case of leukemic B lymphocytes.
    Type: Grant
    Filed: December 21, 2007
    Date of Patent: March 4, 2014
    Assignee: The Medicines Company (Leipzig) GmbH
    Inventors: Claudia Reichelt, Alexander Schulze, Mohammed Daghish, Friedrich-Alexander Ludwig, Jochen Heinicke, Konrad Herrmann, Maj Schuster, Sven Letschert, Kenneth Mugridge, Joseph DeAngelo
  • Patent number: 8598206
    Abstract: The invention provides compounds that are effective as inhibitors of human plasmin and plasma kallikrein, and that are useful for the prevention of blood loss and as components of fibrin adhesives. The invention further provides methods of making and using the compounds.
    Type: Grant
    Filed: January 28, 2011
    Date of Patent: December 3, 2013
    Assignee: The Medicines Company (Leipzig) GmbH
    Inventors: Peter Herold, Mohammed Daghish, Stjepan Jelakovic, Friedrich-Alexander Ludwig, Claudia Reichelt, Alexander Schulze, Andrea Schweinitz
  • Patent number: 8513461
    Abstract: The invention relates to inhibitors of trypsin-like serine proteases, including those of the general formula (IV) which, as well as plasmin, also inhibit plasma kallikrien, and to their use as medicaments, preferably for treatment of blood loss, especially in the case of hyperfibrinolytic states, in organ transplants or heart surgery interventions, in particular with a cardiopulmonary bypass, or as a constituent of a fibrin adhesive.
    Type: Grant
    Filed: February 19, 2013
    Date of Patent: August 20, 2013
    Assignee: The Medicines Company (Leipzig) GmbH
    Inventors: Torsten Steinmetzer, Andrea Schweinitz, Joerg Stuerzebecher, Peter Steinmetzer, Anett Soeffing, Andreas Van De Locht, Silke Nicklisch, Claudia Reichelt, Friedrich-Alexander Ludwig, Alexander Schulze, Mohammed Daghish, Jochen Heinicke
  • Patent number: 8497245
    Abstract: The invention provides methods of making and using compounds of the formula: or a pharmaceutically acceptable salt thereof; wherein n is an integer between 1 and 2 inclusively; m is an integer between 0 and 2 inclusively; X is selected from the group consisting of CH or N; R1 is selected from the group consisting of —CH2NH2, and R2 is selected from the group consisting of —H, —OH, —NH2 and acetyl; R3 is selected from the group consisting of —H, benzyloxycarbonyl and benzylsulfonyl; and R4 is selected from the group consisting of —OH, wherein p is an integer between 0 and 2 inclusively, Y is selected from the group consisting of —O—, —S—, —S(?O)—, —SO2—, methylene, —CH(OH)—, —CH(NH2)—, —CH(CH2—OH)—, —CH(CH2—NH2)— or —N(R6)—, R5 is selected from the group consisting of —H or a simple (C1-C3) alkyl and R6 is selected from the group consisting of —H, a simple (C1-C3) alkyl or a simple (C1-C3) acyl.
    Type: Grant
    Filed: December 21, 2011
    Date of Patent: July 30, 2013
    Assignee: The Medicines Company (Leipzig) GmbH
    Inventors: Peter Herold, Stjepan Jelakovic, Mohammed Daghish, Claudia Reichelt, Alexander Schulze, Andrea Schweinitz, Friedrich-Alexander Ludwig, Adel Rafai Far, Ting Kang
  • Patent number: 8410310
    Abstract: The invention relates to inhibitors of trypsin-like serine proteases of the general formula (I) which, as well as plasmin, also inhibit plasma kallikrein, and to their preparation and use as medicaments, preferably for treatment of blood loss, especially in the case of hyperfibrinolytic states, in organ transplants or heart surgery interventions, in particular with a cardiopulmonary bypass, or as a constituent of a fibrin adhesive.
    Type: Grant
    Filed: May 14, 2012
    Date of Patent: April 2, 2013
    Assignee: The Medicines Company (Leipzig) GmbH
    Inventors: Torsten Steinmetzer, Andrea Schweinitz, Joerg Stuerzebecher, Peter Steinmetzer, Anett Soeffing, Andreas Van De Locht, Silke Nicklisch, Claudia Reichelt, Friedrich-Alexander Ludwig, Alexander Schulze, Mohammed Daghish, Jochen Heinicke
  • Publication number: 20120252743
    Abstract: The invention provides methods of making and using compounds of the formula: or a pharmaceutically acceptable salt thereof; wherein n is an integer between 1 and 2 inclusively; m is an integer between 0 and 2 inclusively; X is selected from the group consisting of CH or N; R1 is selected from the group consisting of —CH2NH2, and R2 is selected from the group consisting of —H, —OH, —NH2 and acetyl; R3 is selected from the group consisting of —H, benzyloxycarbonyl and benzylsulfonyl; and R4 is selected from the group consisting of —OH, wherein p is an integer between 0 and 2 inclusively, Y is selected from the group consisting of —O—, —S—, —S(?O)—, —SO2—, methylene, —CH(OH)—, —CH(NH2)—, —CH(CH2—OH)—, —CH(CH2—NH2)— or —N(R6)—, R5 is selected from the group consisting of —H or a simple (C1-C3) alkyl and R6 is selected from the group consisting of —H, a simple (C1-C3) alkyl or a simple (C1-C3) acyl.
    Type: Application
    Filed: December 21, 2011
    Publication date: October 4, 2012
    Applicant: The Medicines Company (Leipzig) GmbH
    Inventors: Peter Herold, Stjepan Jelakovic, Mohammed Daghish, Claudia Reichelt, Alexander Schulze, Andrea Schweinitz, Friedrich-Alexander Ludwig, Adel Rafai Far, Ting Kang
  • Publication number: 20120225913
    Abstract: The invention relates to inhibitors of trypsin-like serine proteases of the general formula (I) which, as well as plasmin, also inhibit plasma kallikrein, and to their preparation and use as medicaments, preferably for treatment of blood loss, especially in the case of hyperfibrinolytic states, in organ transplants or heart surgery interventions, in particular with a cardiopulmonary bypass, or as a constituent of a fibrin adhesive.
    Type: Application
    Filed: May 14, 2012
    Publication date: September 6, 2012
    Applicant: The Medicine Company (Leipzig) GmbH
    Inventors: Torsten STEINMETZER, Andrea Schweinitz, Joerg Stuerzebecher, Peter Steinmetzer, Anett Soeffing, Andreas Van De Locht, Silke Nicklisch, Claudia Reichelt, Friedrich-Alexander Ludwig, Alexander Schulze, Mohammed Daghisch, Jochen Heinicke
  • Patent number: 8207378
    Abstract: The invention relates to inhibitors of trypsin-like serine proteases of the general formula (I) which, as well as plasmin, also inhibit plasma kallikrien, and to their preparation and use as medicaments, preferably for treatment of blood loss, especially in the case of hyperfibrinolytic states, in organ transplants or heart surgery interventions, in particular with a cardiopulmonary bypass, or as a constituent of a fibrin adhesive.
    Type: Grant
    Filed: April 24, 2009
    Date of Patent: June 26, 2012
    Assignee: The Medicines Company (Leipzig) GmbH
    Inventors: Torsten Steinmetzer, Andrea Schweinitz, Joerg Stuerzebecher, Peter Steinmetzer, Anett Soeffing, Andreas Van De Locht, Silke Nicklisch, Claudia Reichelt, Friedrich-Alexander Ludwig, Alexander Schulze, Mohammed Daghisch, Jochen Heinicke
  • Publication number: 20120094987
    Abstract: The invention relates to compounds of general formula (I); 1a, 1b, 1c and 1d. The invention also relates to a method for the production thereof, pharmaceutical preparations containing said compounds and/or physiologically compatible salts thereof which can be produced therefrom and/or solvates thereof, and to the pharmaceutical use of said compounds, salts or solvates thereof as inhibitors of phosphodiesterase 4. The compounds comprise active ingredients for the treatment of diseases which can have a positive influence by inhibiting the activity of phosphodiesterase 4 and/or TNF?-release, for example, in lymphocytes, eosinophile and basophile granulocytes, macrophages and mastocytes.
    Type: Application
    Filed: October 3, 2011
    Publication date: April 19, 2012
    Inventors: Claudia Reichelt, Alexander Ludwig, Alexander Schulze, Mohammed Daghish, Siegfried Leistner, Andreas Krödel, Jochen Heinicke
  • Publication number: 20110301196
    Abstract: The invention provides compounds that are effective as inhibitors of human plasmin and plasma kallikrein, and that are useful for the prevention of blood loss and as components of fibrin adhesives. The invention further provides methods of making and using the compounds.
    Type: Application
    Filed: January 28, 2011
    Publication date: December 8, 2011
    Applicant: The Medicines Company (Leipzig) GmbH
    Inventors: Peter HEROLD, Mohammed DAGHISH, Stjepan JELAKOVIC, Friedrich-Alexander LUDWIG, Claudia REICHELT, Alexander SCHULZE, Andrea SCHWEINITZ
  • Patent number: 8058285
    Abstract: The invention relates to compounds of general formula (I); 1a, 1 b, 1 c and 1 d. The invention also relates to a method for the production thereof, pharmaceutical preparations containing said compounds and/or physiologically compatible salts thereof which can be produced therefrom and/or solvates thereof, and to the pharmaceutical use of said compounds, salts or solvates thereof as inhibitors of phosphodiesterase 4. The compounds comprise active ingredients for the treatment of diseases which can have a positive influence by inhibiting the activity of phosphodiesterase 4 and/or TNF?-release, for example, in lymphocytes, eosinophile and basophile granulocytes, macrophages and mastocytes.
    Type: Grant
    Filed: January 22, 2007
    Date of Patent: November 15, 2011
    Assignee: The Medicines Company (Leipzig) GmbH
    Inventors: Claudia Reichelt, Alexander Ludwig, Alexander Schulze, Mohammed Daghish, Siegfried Leistner, Andreas Krödel, Jochen Heinicke
  • Publication number: 20110021511
    Abstract: The invention relates to compounds of general formula 1 to processes for the production thereof, to pharmaceutical preparations containing said compounds and/or physiologically compatible salts and/or solvates which can be produced therefrom as well as to the pharmaceutical use of said compounds, the salts or solvates thereof as inductors of apoptosis in the case of non-solid malignant tumors of the hematopoietic system, in particular in the case of leukemias and lymphomas, more particularly in the case of leukemic B lymphocytes.
    Type: Application
    Filed: December 21, 2007
    Publication date: January 27, 2011
    Applicant: THE MEDICINES COMPANY (LEIPZIG) GMBH
    Inventors: Claudia Reichelt, Alexander Schulze, Mohammed Daghish, Friedrich-Alexander Ludwig, Jochen Heinicke, Konrad Herrmann, Maj Schuster, Sven Letschert, Kenneth Mugridge, Joseph DeAngelo
  • Publication number: 20100022781
    Abstract: The invention relates to inhibitors of trypsin-like serine proteases of the general formula (I) which, as well as plasmin, also inhibit plasma kallikrien, and to their preparation and use as medicaments, preferably for treatment of blood loss, especially in the case of hyperfibrinolytic states, in organ transplants or heart surgery interventions, in particular with a cardiopulmonary bypass, or as a constituent of a fibrin adhesive.
    Type: Application
    Filed: April 24, 2009
    Publication date: January 28, 2010
    Inventors: Torsten Steinmetzer, Andrea Schweinitz, Joerg Stuerzebecher, Peter Steinmetzer, Anett Soffing, Andreas Van De Locht, Silke Nicklisch, Claudia Reichelt, Friedrich-Alexander Ludwig, Alexander Schulze, Mohammed Daghisch, Jochen Heinicke
  • Publication number: 20080160028
    Abstract: The invention relates to compounds of general formula (I); 1a, 1 b, 1 c and 1 d. The invention also relates to a method for the production thereof, pharmaceutical preparations containing said compounds and/or physiologically compatible salts thereof which can be produced therefrom and/or solvates thereof, and to the pharmaceutical use of said compounds, salts or solvates thereof as inhibitors of phosphodiesterase 4. The compounds comprise active ingredients for the treatment of diseases which can have a positive influence by inhibiting the activity of phosphodiesterase 4 and/or TNF?-release, for example, in lymphocytes, eosinophile and basophile granulocytes, macrophages and mastocytes.
    Type: Application
    Filed: January 22, 2007
    Publication date: July 3, 2008
    Inventors: Claudia Reichelt, Alexander Ludwig, Alexander Schulze, Mohammed Daghish, Siegfried Leistner, Andreas Krodel, Jochen Heinicke
  • Patent number: 6749313
    Abstract: Plate-type luminaire comprising a prism plate with a smooth upper plate surface and a prism lower surface formed by a plurality of longitudinal ribs; a cover plate made of translucent material resting on the prism surface; and an optical-waveguide plate on the smooth plate surfaces of the prism plate. The plates are curved continuously in the same direction of curvature, transversely to the longitudinal direction of the longitudinal ribs of the prism plate, at least over most of the plate width, with the longitudinal ribs being located on the inside of the arc of curvature of the prism plate. A reflector plate may be disposed over the waveguide plate, with a smooth or a longitudinally ribbed surface.
    Type: Grant
    Filed: January 16, 2003
    Date of Patent: June 15, 2004
    Assignee: Ludwig Leuchten KG
    Inventors: Alexander Ludwig, Rudolf Rieger, Tibor Csizy
  • Publication number: 20030133285
    Abstract: Plate-type luminaire comprising a prism plate with a smooth upper plate surface and a prism lower surface formed by a plurality of longitudinal ribs; a cover plate made of translucent material resting on the prism surface; and an optical-waveguide plate on the smooth plate surfaces of the prism plate. The plates are curved continuously in the same direction of curvature, transversely to the longitudinal direction of the longitudinal ribs of the prism plate, at least over most of the plate width, with the longitudinal ribs being located on the inside of the arc of curvature of the prism plate. A reflector plate may be disposed over the waveguide plate, with a smooth or a longitudinally ribbed surface.
    Type: Application
    Filed: January 16, 2003
    Publication date: July 17, 2003
    Applicant: Ludwig Leuchten KG
    Inventors: Alexander Ludwig, Rudolf Rieger, Tibor Csizy