Patents by Inventor Alexander M. Cole

Alexander M. Cole has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND PRODUCTS FOR REAWAKENING RETROCYCLINS
    Publication number: 20140336244
    Abstract: Products and methods are provided for the restoring the endogenous expression of theta-defensins, such as retrocyclin-1, in mamallian cells. The present invention also includes products and methods for inhibiting sexually transmitted virus entry, e.g., HIV-1 virus entry, into a mammalian cell via, for example, administering to a subject an amount of a read-through mediating agent sufficient to induce exogenous expression of an amount of retrocyclin nonapeptides in the mammalian cell.
    Type: Application
    Filed: May 19, 2014
    Publication date: November 13, 2014
    Applicant: University of Central Florida Research Foundation, Inc.
    Inventor: Alexander M. Cole
  • Methods and products for reawakening retrocyclins
    Patent number: 8765698
    Abstract: Products and methods are provided for the restoring the endogenous expression of theta-defensins, such as retrocyclin-1, in mamallian cells. The present invention also includes products and methods for inhibiting sexually transmitted virus entry, e.g., HIV-1 virus entry, into a mammalian cell via, for example, administering to a subject an amount of a read-through mediating agent sufficient to induce exogenous expression of an amount of retrocyclin nonapeptides in the mammalian cell.
    Type: Grant
    Filed: February 3, 2010
    Date of Patent: July 1, 2014
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventor: Alexander M. Cole
  • Methods and Products for Reawakening Retrocyclins
    Publication number: 20110190385
    Abstract: Products and methods are provided for the restoring the endogenous expression of theta-defensins, such as retrocyclin-1, in mamallian cells. The present invention also includes products and methods for inhibiting sexually transmitted virus entry, e.g., HIV-1 virus entry, into a mammalian cell via, for example, administering to a subject an amount of a read-through mediating agent sufficient to induce exogenous expression of an amount of retrocyclin nonapeptides in the mammalian cell.
    Type: Application
    Filed: February 3, 2010
    Publication date: August 4, 2011
    Inventor: Alexander M. Cole
  • Retrocyclins: antiviral and antimicrobial peptides
    Patent number: 7718610
    Abstract: Retrocyclin peptides are small antimicrobial agents with potent activity against bacteria and viruses. The peptides are nonhemolytic, and exhibit minimal in vitro cytotoxicity. A pharmaceutical composition comprising retrocyclin as an active agent is administered therapeutically to a patient suffering from a bacterial and/or viral infection, or to an individual facing exposure to a bacterial and/or viral infection, especially one caused by the HIV-1 retrovirus or other sexually-transmitted pathogens.
    Type: Grant
    Filed: January 1, 2008
    Date of Patent: May 18, 2010
    Assignee: The Regents of the University of California
    Inventors: Robert I. Lehrer, Alan J. Waring, Alexander M. Cole, Teresa B. Hong
  • RETROCYCLINS: ANTIVIRAL AND ANTIMICROBIAL PEPTIDES
    Publication number: 20090264344
    Abstract: Retrocyclin peptides are small antimicrobial agents with potent activity against bacteria and viruses. The peptides are nonhemolytic, and exhibit minimal in vitro cytotoxicity. A pharmaceutical composition comprising retrocyclin as an active agent is administered therapeutically to a patient suffering from a bacterial and/or viral infection, or to an individual facing exposure to a bacterial and/or viral infection, especially one caused by the HIV-1 retrovirus or other sexually-transmitted pathogens.
    Type: Application
    Filed: January 1, 2008
    Publication date: October 22, 2009
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: ROBERT I. LEHRER, ALAN J. WARING, ALEXANDER M. COLE, TERESA B. HONG
  • Retrocyclins: antiviral and antimicrobial peptides
    Patent number: 7314858
    Abstract: Retrocyclin peptides are small antimicrobial agents with potent activity against bacteria and viruses. The peptides are nonhemolytic, and exhibit minimal in vitro cytotoxicity. A pharmaceutical composition comprising retrocyclin as an active agent is administered therapeutically to a patient suffering from a bacterial and/or viral infection, or to an individual facing exposure to a bacterial and/or viral infection, especially one caused by the HIV-1 retrovirus or other sexually-transmitted pathogens.
    Type: Grant
    Filed: November 5, 2004
    Date of Patent: January 1, 2008
    Assignee: The Regents of the University of California
    Inventors: Robert I. Lehrer, Alan J. Waring, Alexander M. Cole, Teresa B. Hong
  • Retrocyclins: antiviral and antimicrobial peptides
    Patent number: 6713078
    Abstract: Retrocyclin peptides are small antimicrobial agents with potent activity against bacteria and viruses. The peptides are nonhemolytic, and exhibit minimal in vitro cytotoxicity. A pharmaceutical composition comprising retrocyclin as an active agent is administered therapeutically to a patient suffering from a bacterial and/or viral infection, or to an individual facing exposure to a bacterial and/or viral infection, especially one caused by the HIV-1 retrovirus or other sexually-transmitted pathogens.
    Type: Grant
    Filed: May 6, 2002
    Date of Patent: March 30, 2004
    Assignee: The Regents of the University of California
    Inventors: Robert I. Lehrer, Alan J. Waring, Alexander M. Cole, Teresa B. Hong
  • Retrocyclins: antiviral and antimicrobial peptides
    Publication number: 20030144184
    Abstract: Retrocyclin peptides are small antimicrobial agents with potent activity against bacteria and viruses. The peptides are nonhemolytic, and exhibit minimal in vitro cytotoxicity. A pharmaceutical composition comprising retrocyclin as an active agent is administered therapeutically to a patient suffering from a bacterial and/or viral infection, or to an individual facing exposure to a bacterial and/or viral infection, especially one caused by the HIV-1 retrovirus or other sexually-transmitted pathogens.
    Type: Application
    Filed: May 6, 2002
    Publication date: July 31, 2003
    Inventors: Robert I. Lehrer, Alan J. Waring, Alexander M. Cole, Teresa B. Hong