Patents by Inventor Alexander M. Gaspar

Alexander M. Gaspar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diagnosing autoimmune rheumatoid arthritis by measuring proteolytic activity of .alpha..sub.2 -macroglobulin
    Patent number: 4499186
    Abstract: A method for diagnosis of rheumatoid arthritis and related autoimmune diseases comprises blocking calcium ions contained in a blood sample, effecting hydrolysis of a selected substrate in the presence of .alpha..sub.2 -macroglobulin (.alpha..sub.2 M) from the blood sample, and determining the extent of hydrolysis of the substrate. Preferably, .alpha..sub.2 M in plasma is incubated with a hydrolyzable chromogenic substrate and the liberated chromogen is determined spectrophotometrically. A diagnostic kit is also provided.
    Type: Grant
    Filed: December 30, 1982
    Date of Patent: February 12, 1985
    Assignee: University of Illinois, Board of Trustees
    Inventors: Marius C. Teodorescu, Alexander M. Gaspar, Gregory T. Spear, Doina Ganea, John L. Skosey