Patents by Inventor Alexander MacKenzie

Alexander MacKenzie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Detecting and treating dementia
    Patent number: 9486541
    Abstract: This document relates to methods and materials for detecting mutations that can be linked to dementia. For example, methods and materials for detecting one or more mutations within PGRN nucleic acid are provided. This document also provides methods and materials for detecting the level of progranulin expression. In addition, this document relates to methods and materials for treating mammals having a neurodegenerative disorder (e.g., dementia). For example, methods and materials for increasing PGRN polypeptide levels in mammals are provided, as are methods and materials for identifying agents that can be used to increase PGRN polypeptide levels in mammals.
    Type: Grant
    Filed: July 1, 2013
    Date of Patent: November 8, 2016
    Assignees: Mayo Foundation for Medical Education and Research, VIB VZW, Universteit Antwerpen, The University of British Columbia, The University of Manchester
    Inventors: Michael L. Hutton, Matthew Charles Baker, Jennifer Mae Gass, Rosa Rademakers, Jason Eriksen, Stuart M. Pickering-Brown, Ian Reid Alexander Mackenzie, Howard Feldman, Samir Kumar-Singh, Christine Van Broeckhoven, Marc Cruts, Ashley Diane Cannon
  • DETECTING AND TREATING DEMENTIA
    Publication number: 20130345142
    Abstract: This document relates to methods and materials for detecting mutations that can be linked to dementia. For example, methods and materials for detecting one or more mutations within PGRN nucleic acid are provided. This document also provides methods and materials for detecting the level of progranulin expression. In addition, this document relates to methods and materials for treating mammals having a neurodegenerative disorder (e.g., dementia). For example, methods and materials for increasing PGRN polypeptide levels in mammals are provided, as are methods and materials for identifying agents that can be used to increase PGRN polypeptide levels in mammals.
    Type: Application
    Filed: July 1, 2013
    Publication date: December 26, 2013
    Applicants: Mayo Foundation for Medical Education and Research, Vib VZW, The University of Manchester, The University of British Columbia, Universiteit Antwerpen
    Inventors: Michael L. Hutton, Matthew Charles Baker, Jennifer Mae Gass, Rosa Rademakers, Jason Eriksen, Stuart M. Pickering-Brown, Ian Reid Alexander Mackenzie, Howard Feldman, Samir Kumar-Singh, Christine Van Broeckhoven, Marc Cruts, Ashley Diane Cannon
  • Detecting and treating dementia
    Patent number: 8486635
    Abstract: This document relates to methods and materials for detecting mutations that can be linked to dementia. For example, methods and materials for detecting one or more mutations within PGRN nucleic acid are provided. This document also provides methods and materials for detecting the level of progranulin expression. In addition, this document relates to methods and materials for treating mammals having a neurodegenerative disorder (e.g., dementia). For example, methods and materials for increasing PGRN polypeptide levels in mammals are provided, as are methods and materials for identifying agents that can be used to increase PGRN polypeptide levels in mammals.
    Type: Grant
    Filed: May 30, 2007
    Date of Patent: July 16, 2013
    Assignees: Mayo Foundation for Medical Education and Research, The University of British Columbia, The University of Manchester, VIB VZW, Universiteit Antwerpen
    Inventors: Michael L. Hutton, Matthew Charles Baker, Jennifer Mae Gass, Rosa Rademakers, Jason Eriksen, Stuart M. Pickering-Brown, Ian Reid Alexander Mackenzie, Howard Feldman, Samir Kumar-Singh, Christine Van Broeckhoven, Marc Cruts, Ashley Diane Cannon
  • DETECTING AND TREATING DEMENTIA
    Publication number: 20100105034
    Abstract: This document relates to methods and materials for detecting mutations that can be linked to dementia. For example, methods and materials for detecting one or more mutations within PGRN nucleic acid are provided. This document also provides methods and materials for detecting the level of progranulin expression. In addition, this document relates to methods and materials for treating mammals having a neurodegenerative disorder (e.g., dementia). For example, methods and materials for increasing PGRN polypeptide levels in mammals are provided, as are methods and materials for identifying agents that can be used to increase PGRN polypeptide levels in mammals.
    Type: Application
    Filed: May 30, 2007
    Publication date: April 29, 2010
    Inventors: Michael L. Hutton, Matthew Colin Baker, Jennifer Mae Gass, Rosa Rademakers, Jason Eriksen, Stuart M. Pickering-Brown, Ian Reid Alexander Mackenzie, Howard Feldman, Samir Kumar-Singh, Christine Van Broeckhoven, Marc Cruts
  • Detection and modulation of IAPs and NAIP for the diagnosis and treatment of proliferative disease
    Publication number: 20070203088
    Abstract: Disclosed are diagnostic and prognostic kits for the detection and treatment of proliferative diseases such as ovarian cancer, breast cancer, and lymphoma. Also disclosed are cancer therapeutics utilizing IAP antisense nucleic acids, IAP fragments, and antibodies which specifically bind IAP polypeptides.
    Type: Application
    Filed: August 25, 2006
    Publication date: August 30, 2007
    Inventors: Robert Korneluk, Alexander MacKenzie, Peter Liston, Stephen Baird, Benjamin Tsang, Christine Pratt
  • XAF genes and polypeptides: methods and reagents for modulating apoptosis
    Publication number: 20070202096
    Abstract: The invention provides novel XAF nucleic acid sequences. Also provided are XAF polypeptides, anti-XAF antibodies, and methods for modulating apoptosis and detecting compounds which modulate apoptosis.
    Type: Application
    Filed: August 4, 2006
    Publication date: August 30, 2007
    Inventors: Robert Korneluk, Katsuyuki Tamai, Peter Liston, Alexander MacKenzie
  • XAF genes and polypeptides: methods and reagents for modulating apoptosis
    Publication number: 20070072217
    Abstract: The invention provides novel XAF nucleic acid sequences. Also provided are XAF polypeptides, anti-XAF antibodies, and methods for modulating apoptosis and detecting compounds which modulate apoptosis.
    Type: Application
    Filed: August 4, 2006
    Publication date: March 29, 2007
    Inventors: Robert Korneluk, Katsuyuki Tamai, Peter Liston, Alexander MacKenzie
  • Mammalian IAP gene family, primers, probes and detection methods
    Publication number: 20070066524
    Abstract: Disclosed is substantially pure DNA encoding mammalian IAP polypeptides; and methods of using such DNA to express the IAP polypeptides in cells and animals to inhibit apoptosis. Also disclosed are conserved regions characteristic of the IAP family and primer and probes for the identification and isolation of additional IAP genes. In addition, methods for treating diseases and disorders involving apoptosis are provided.
    Type: Application
    Filed: August 4, 2006
    Publication date: March 22, 2007
    Inventors: Robert Korneluk, Alexander MacKenzie, Stephen Baird, Peter Liston
  • Mammalian IAP gene family, primers, probes and detection methods
    Publication number: 20070048772
    Abstract: Disclosed is substantially pure DNA encoding mammalian IAP polypeptides; and methods of using such DNA to express the IAP polypeptides in cells and animals to inhibit apoptosis. Also disclosed are conserved regions characteristic of the IAP family and primer and probes for the identification and isolation of additional IAP genes. In addition, methods for treating diseases and disorders involving apoptosis are provided.
    Type: Application
    Filed: July 26, 2006
    Publication date: March 1, 2007
    Inventors: Robert Korneluk, Alexander MacKenzie, Stephen Baird, Peter Liston
  • Mammalian IAP gene family, primers, probes and detection methods
    Publication number: 20070042446
    Abstract: Disclosed is substantially pure DNA encoding mammalian IAP polypeptides; and methods of using such DNA to express the IAP polypeptides in cells and animals to inhibit apoptosis. Also disclosed are conserved regions characteristic of the IAP family and primer and probes for the identification and isolation of additional IAP genes. In addition, methods for treating diseases and disorders involving apoptosis are provided.
    Type: Application
    Filed: August 3, 2006
    Publication date: February 22, 2007
    Inventors: Robert Korneluk, Alexander MacKenzie, Stephen Baird, Peter Liston
  • Mammalian IAP gene family, primers, probes and detection methods
    Publication number: 20070031903
    Abstract: Disclosed is substantially pure DNA encoding mammalian IAP polypeptides; and methods of using such DNA to express the IAP polypeptides in cells and animals to inhibit apoptosis. Also disclosed are conserved regions characteristic of the IAP family and primer and probes for the identification and isolation of additional IAP genes. In addition, methods for treating diseases and disorders involving apoptosis are provided.
    Type: Application
    Filed: July 25, 2006
    Publication date: February 8, 2007
    Inventors: Robert Korneluk, Alexander MacKenzie, Stephen Baird, Peter Liston
  • Mammalian IAP gene family, primers, probes and detection methods
    Publication number: 20070031904
    Abstract: Disclosed is substantially pure DNA encoding mammalian IAP polypeptides; and methods of using such DNA to express the IAP polypeptides in cells and animals to inhibit apoptosis. Also disclosed are conserved regions characteristic of the IAP family and primer and probes for the identification and isolation of additional IAP genes. In addition, methods for treating diseases and disorders involving apoptosis are provided.
    Type: Application
    Filed: July 25, 2006
    Publication date: February 8, 2007
    Inventors: Robert Korneluk, Alexander MacKenzie, Stephen Baird, Peter Liston
  • Mammalian IAP gene family, primers, probes and detection methods
    Publication number: 20070026470
    Abstract: Disclosed is substantially pure DNA encoding mammalian IAP polypeptides; and methods of using such DNA to express the IAP polypeptides in cells and animals to inhibit apoptosis. Also disclosed are conserved regions characteristic of the IAP family and primer and probes for the identification and isolation of additional IAP genes. In addition, methods for treating diseases and disorders involving apoptosis are provided.
    Type: Application
    Filed: July 25, 2006
    Publication date: February 1, 2007
    Inventors: Robert Korneluk, Alexander MacKenzie, Stephen Baird, Peter Liston
  • Mammalian IAP gene family, primers, probes and detection methods
    Publication number: 20070027304
    Abstract: Disclosed is substantially pure DNA encoding mammalian IAP polypeptides; and methods of using such DNA to express the IAP polypeptides in cells and animals to inhibit apoptosis. Also disclosed are conserved regions characteristic of the IAP family and primer and probes for the identification and isolation of additional IAP genes. In addition, methods for treating diseases and disorders involving apoptosis are provided.
    Type: Application
    Filed: July 26, 2006
    Publication date: February 1, 2007
    Inventors: Robert Korneluk, Alexander MacKenzie, Stephen Baird, Peter Liston
  • Mammalian IAP gene family, primers, probes and detection methods
    Publication number: 20070026494
    Abstract: Disclosed is substantially pure DNA encoding mammalian IAP polypeptides; and methods of using such DNA to express the IAP polypeptides in cells and animals to inhibit apoptosis. Also disclosed are conserved regions characteristic of the IAP family and primer and probes for the identification and isolation of additional IAP genes. In addition, methods for treating diseases and disorders involving apoptosis are provided.
    Type: Application
    Filed: July 26, 2006
    Publication date: February 1, 2007
    Inventors: Robert Korneluk, Alexander MacKenzie, Stephen Baird, Peter Liston
  • Mammalian IAP gene family, primers, probes, and detection methods
    Publication number: 20070009971
    Abstract: Disclosed is substantially pure DNA encoding mammalian IAP polypeptides; substantially pure polypeptides; and methods of using such DNA to express the IAP polypeptides in cells and animals to inhibit apoptosis. Also disclosed are conserved regions characteristic of the IAP family and primers and probes for the identification and isolation of additional IAP genes. In addition, methods for treating diseases and disorders involving apoptosis are provided.
    Type: Application
    Filed: December 22, 2005
    Publication date: January 11, 2007
    Applicant: Aegera Therapeutics, Inc.
    Inventors: Robert Korneluk, Alexander MacKenzie, Stephen Baird, Peter Liston
  • Mammalian IAP gene family, primers, probes and detection methods
    Publication number: 20060205021
    Abstract: Disclosed is substantially pure DNA encoding mammalian IAP polypeptides; substantially pure polypeptides; and methods of using such DNA to express the IAP polypeptides in cells and animals to inhibit apoptosis. Also disclosed are conserved regions characteristic of the IAP family and primers and probes for the identification and isolation of additional IAP genes. In addition, methods for treating diseases and disorders involving apoptosis are provided.
    Type: Application
    Filed: January 19, 2006
    Publication date: September 14, 2006
    Applicant: Aegera Therapeutics, Inc.
    Inventors: Robert Korneluk, Alexander MacKenzie, Stephen Baird, Peter Liston
  • Detection and modulation of IAPS and NAIP for the diagnosis and treatment of proliferative disease
    Publication number: 20060189563
    Abstract: Disclosed are diagnostic and prognostic kits for the detection and treatment of proliferative diseases such as ovarian cancer, breast cancer, and lymphoma. Also disclosed are cancer therapeutics utilizing IAP antisense nucleic acids IAP fragments, and antibodies which specifically bind IAP polypeptides.
    Type: Application
    Filed: March 20, 2006
    Publication date: August 24, 2006
    Inventors: Robert Korneluk, Alexander MacKenzie, Peter Liston, Stephen Baird, Benjamin Tsang, Christine Pratt
  • Use of neuronal apoptosis inhibitor protein (NAIP)
    Publication number: 20060172348
    Abstract: The invention provides a novel NAIP nucleic and sequences. Also provided are anti-NAIP antibodies and methods for modulating apoptosis and detecting compounds which modulate apoptosis.
    Type: Application
    Filed: January 10, 2006
    Publication date: August 3, 2006
    Applicant: University of Ottawa
    Inventors: Robert Korneluk, Alexander MacKenzie, Natalie Roy, George Robertson, Katsu Tamai
  • Fan
    Patent number: D747453
    Type: Grant
    Filed: July 7, 2014
    Date of Patent: January 12, 2016
    Assignee: Dyson Technology Limited
    Inventors: Neil Andrew Stewart, Joseph Eric Hodgetts, Leanne Joyce Garner, Peter David Gammack, Alexander Mackenzie Burn