Patents by Inventor Alexander Malkin
Alexander Malkin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11883622Abstract: A transdermal drug delivery device is disclosed that may comprise a housing including an upper housing portion and a lower housing portion. The lower housing portion may define a bottom surface including skin attachment means for releasably attaching the lower housing portion to skin of a user. The upper housing portion may at least partially surround a central region of the device. The device may also include a microneedle assembly and a reservoir disposed within the central region. The reservoir may be in fluid communication with the microneedle assembly. Additionally, the device may include a pushing element disposed above the microneedle assembly within the central region. The pushing element may be configured to provide a continuous bilateral force having a downward component transmitted through the microneedle assembly and an upward component transmitted through the skin attachment means.Type: GrantFiled: February 18, 2021Date of Patent: January 30, 2024Assignee: SORRENTO THERAPEUTICS, INC.Inventors: Russell F. Ross, Luke Hagan, Alexander Malkin, Derek Hatchett, Jacob Marks, Thomas Lutzow
-
Publication number: 20230219087Abstract: A system or method for detecting an immune system activation state in a patient can include a sample preparation system configured to isolate white blood cells from a sample of the patient, a cytometry module configured to determine biophysical properties of the white blood cells of the sample, and an analysis module configured to analyze the biophysical properties.Type: ApplicationFiled: June 15, 2022Publication date: July 13, 2023Inventors: Henry Tat Kwong Tse, Ajay M. Shah, Lionel Guillou, Alexander Malkin, Anne E. Jensen, Nicholas Martinez, Carissa Colegrove, Laura Voyen
-
Publication number: 20230221224Abstract: A method and/or system can include processing a blood sample of a patient by degrading red blood cells of the blood sample using a lysing solution, quenching the degradation of the red blood cells after a threshold lysing time, centrifuging and aspirating the quenched solution to remove degraded red blood cell debris and concentrate white blood cells of the blood sample, and suspending the concentrated white blood cells in a buffer solution; within a threshold transfer time, deforming white blood cells, of the suspended white blood cells, within a microfluidic chip; and determining a probability that the patient is in an immune activation state based on images of the white blood cells acquired while deforming the white blood cells.Type: ApplicationFiled: June 15, 2022Publication date: July 13, 2023Inventors: Henry Tat Kwong Tse, Ajay M. Shah, Lionel Guillou, Alexander Malkin, Anne E. Jensen, Nicholas Martinez, Carissa Colegrove, Laura Voyen
-
Patent number: 11592371Abstract: A method and/or system can include processing a blood sample of a patient by degrading red blood cells of the blood sample using a lysing solution, quenching the degradation of the red blood cells after a threshold lysing time, centrifuging and aspirating the quenched solution to remove degraded red blood cell debris and concentrate white blood cells of the blood sample, and suspending the concentrated white blood cells in a buffer solution; within a threshold transfer time, deforming white blood cells, of the suspended white blood cells, within a microfluidic chip; and determining a probability that the patient is in an immune activation state based on images of the white blood cells acquired while deforming the white blood cells.Type: GrantFiled: January 13, 2022Date of Patent: February 28, 2023Assignee: CytoVale Inc.Inventors: Henry Tat Kwong Tse, Ajay M. Shah, Lionel Guillou, Alexander Malkin, Anne E. Jensen, Nicholas Martinez, Carissa Colegrove, Laura Voyen
-
Patent number: 11548003Abstract: A system or method for detecting an immune system activation state in a patient can include a sample preparation system configured to isolate white blood cells from a sample of the patient, a cytometry module configured to determine biophysical properties of the white blood cells of the sample, and an analysis module configured to analyze the biophysical properties.Type: GrantFiled: January 13, 2022Date of Patent: January 10, 2023Assignee: CytoVale Inc.Inventors: Henry Tat Kwong Tse, Ajay M. Shah, Lionel Guillou, Alexander Malkin, Anne E. Jensen, Nicholas Martinez, Carissa Colegrove, Laura Voyen
-
Publication number: 20210170153Abstract: A transdermal drug delivery device is disclosed that may comprise a housing including an upper housing portion and a lower housing portion. The lower housing portion may define a bottom surface including skin attachment means for releasably attaching the lower housing portion to skin of a user. The upper housing portion may at least partially surround a central region of the device. The device may also include a microneedle assembly and a reservoir disposed within the central region. The reservoir may be in fluid communication with the microneedle assembly. Additionally, the device may include a pushing element disposed above the microneedle assembly within the central region. The pushing element may be configured to provide a continuous bilateral force having a downward component transmitted through the microneedle assembly and an upward component transmitted through the skin attachment means.Type: ApplicationFiled: February 18, 2021Publication date: June 10, 2021Inventors: Russell F. Ross, Luke Hagan, Alexander Malkin, Derek Hatchett, Jacob Marks, Thomas Lutzow
-
Patent number: 10953211Abstract: A transdermal drug delivery device is disclosed that may comprise a housing including an upper housing portion and a lower housing portion. The lower housing portion may define a bottom surface including skin attachment means for releasably attaching the lower housing portion to skin of a user. The upper housing portion may at least partially surround a central region of the device. The device may also include a microneedle assembly and a reservoir disposed within the central region. The reservoir may be in fluid communication with the microneedle assembly. Additionally, the device may include a pushing element disposed above the microneedle assembly within the central region. The pushing element may be configured to provide a continuous bilateral force having a downward component transmitted through the microneedle assembly and an upward component transmitted through the skin attachment means.Type: GrantFiled: December 18, 2018Date of Patent: March 23, 2021Assignee: SORRENTO THERAPEUTICS, INC.Inventors: Russell F. Ross, Luke Hagan, Alexander Malkin, Derek Hatchett, Jacob Marks, Thomas Lutzow
-
Publication number: 20190134369Abstract: A transdermal drug delivery device is disclosed that may comprise a housing including an upper housing portion and a lower housing portion. The lower housing portion may define a bottom surface including skin attachment means for releasably attaching the lower housing portion to skin of a user. The upper housing portion may at least partially surround a central region of the device. The device may also include a microneedle assembly and a reservoir disposed within the central region. The reservoir may be in fluid communication with the microneedle assembly. Additionally, the device may include a pushing element disposed above the microneedle assembly within the central region. The pushing element may be configured to provide a continuous bilateral force having a downward component transmitted through the microneedle assembly and an upward component transmitted through the skin attachment means.Type: ApplicationFiled: December 18, 2018Publication date: May 9, 2019Inventors: Russell F. Ross, Luke Hagan, Alexander Malkin, Derek Hatchett, Jacob Marks, Thomas Lutzow
-
Patent number: 10183156Abstract: A transdermal drug delivery device is disclosed that may comprise a housing including an upper housing portion and a lower housing portion. The lower housing portion may define a bottom surface including skin attachment means for releasably attaching the lower housing portion to skin of a user. The upper housing portion may at least partially surround a central region of the device. The device may also include a microneedle assembly and a reservoir disposed within the central region. The reservoir may be in fluid communication with the microneedle assembly. Additionally, the device may include a pushing element disposed above the microneedle assembly within the central region. The pushing element may be configured to provide a continuous bilateral force having a downward component transmitted through the microneedle assembly and an upward component transmitted through the skin attachment means.Type: GrantFiled: February 28, 2014Date of Patent: January 22, 2019Assignee: Sorrento Therapeutics, Inc.Inventors: Russell F. Ross, Luke Hagan, Alexander Malkin, Derek Hatchett, Jacob Marks, Thomas Lutzow
-
Publication number: 20150367117Abstract: A transdermal drug delivery device is disclosed that may comprise a housing including an upper housing portion and a lower housing portion. The lower housing portion may define a bottom surface including skin attachment means for releaseably attaching the lower housing portion to skin of a user. The upper housing portion may at least partially surround a central region of the device. The device may also include a microneedle assembly and a reservoir disposed within the central region. The reservoir may be in fluid communication with the microneedle assembly. Additionally, the device may include a pushing element disposed above the microneedle assembly within the central region. The pushing element may be configured to provide a continuous bilateral force having a downward component transmitted through the microneedle assembly and an upward component transmitted through the skin attachment means.Type: ApplicationFiled: February 28, 2014Publication date: December 24, 2015Inventors: Russell F. Ross, Luke Hagan, Alexander Malkin, Derek Hatchett, Jacob Marks, Thomas Lutzow