Abstract: Techniques and solutions are provided for generating allocation tasks for a plurality of tasks requesting one or more instances of an element, the element being associated with a plurality of allocation units. At least one allocation unit is an aggregation unit that comprises multiple instances of the element. Certain disclosed techniques allow for a combination of types of allocation tasks, such as an allocation task that directly allocates one or more instances of an allocation unit to a task, or an allocation task that has subtasks of withdrawing one or more instances of an aggregation unit and then distributing element instances of the aggregation unit or units among a plurality of tasks. Another technique determines whether a multiple of a given aggregation unit can exactly satisfy multiple tasks of the plurality of tasks. Another aspect provides for splitting tasks into groups to allow for more efficient allocation.

Abstract: Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.

Abstract: Provided herein, inter alia, are anticancer polyketides. The uses of the polyketides described herein include treatment of cancer, for example, through regulation of the spliceosome and detection of spliceosome inhibition.

Abstract: Provided herein, inter alia, are anticancer polyketides. The uses of the polyketides described herein include treatment of cancer, for example, through regulation of the spliceosome and detection of spliceosome inhibition.

Abstract: Methods and apparatuses enable generation of an executed workload electronic record. The executed workload record indicates data related to one or more performance metrics by which performance of a work task is evaluated. One such performance metric is an expected time for completion of the task. Performance of the task can be monitored to determine an actual completion time for the task to compare against an expected completion time. The executed workload record can be used for evaluation of workers. Executed workload records provide centralized, aggregatable information for evaluation purposes.

Abstract: Methods and apparatuses enable generation of a managed space layout model defining permissible pathways for travel through the managed space. Each permissible pathway can be defined as a line segment or an edge bounded by coordinate pairs. Items and locations within the managed space are associated with permissible pathways, which association defines how the items/locations can be reached via travel through the managed space. The information can be saved as a network of nodes, which defines the intersection of the permissible pathways and includes information about the pathways. With the layout model, a path can be determined through the managed space to accomplish work in the managed space. The layout data allows a path distance to be calculated for a given work task that involves travel through the managed space.

Abstract: Systems, methods, and computer-readable medium are disclosed for releasing stock requests to a storage facility, such as a warehouse. Such systems, methods and computer-readable medium may generate a condition record reflecting a predetermined set of conditions to be met by the attributes of a stock request, receive the stock request including one or more attributes about a stock item, determine whether the attributes of the received stock request meet the conditions of the condition record, associate a wave template of the condition record with the stock request if a determination is made that the stock request does meet the condition record, and create a wave object based on each stock request associated with the wave template. The wave object may then be released to the warehouse for fulfillment of each stock request associated with the wave object.

Abstract: Methods and apparatuses enable generation of a managed space layout model defining permissible pathways for travel through the managed space. Each permissible pathway can be defined as a line segment or an edge bounded by coordinate pairs. Items and locations within the managed space are associated with permissible pathways, which association defines how the items/locations can be reached via travel through the managed space. The information can be saved as a network of nodes, which defines the intersection of the permissible pathways and includes information about the pathways. With the layout model, a path can be determined through the managed space to accomplish work in the managed space. The layout data allows a path distance to be calculated for a given work task that involves travel through the managed space.

Abstract: Methods and apparatuses enable generation of an executed workload electronic record. The executed workload record indicates data related to one or more performance metrics by which performance of a work task is evaluated. One such performance metric is an expected time for completion of the task. Performance of the task can be monitored to determine an actual completion time for the task to compare against an expected completion time. The executed workload record can be used for evaluation of workers. Executed workload records provide centralized, aggregatable information for evaluation purposes.

Abstract: Systems, methods, and computer-readable medium are disclosed for releasing stock requests to a storage facility, such as a warehouse. Such systems, methods and computer-readable medium may generate a condition record reflecting a predetermined set of conditions to be met by the attributes of a stock request, receive the stock request including one or more attributes about a stock item, determine whether the attributes of the received stock request meet the conditions of the condition record, associate a wave template of the condition record with the stock request if a determination is made that the stock request does meet the condition record, and create a wave object based on each stock request associated with the wave template. The wave object may then be released to the warehouse for fulfillment of each stock request associated with the wave object.