Abstract: Methods for laser bonding optical elements to substrates and optical assemblies are disclosed. According to one embodiment, a method of bonding an optical element to a substrate includes disposing at least one optical element onto a surface of the substrate, electrostatically affixing the at least one optical element to the surface of the substrate, and directing a laser beam into the at least one optical element. The laser beam heats an interface between at least one optical element and the substrate to a temperature that is higher than a lowest temperature of the optical element change temperature and the substrate change temperature, thereby forming a bond between at least one optical element and the substrate at a bond area. The laser beam has a fluence that does not modify the substrate at areas of the substrate that are outside of the at least one optical element.

Abstract: An inkjet printer has a print assembly and a print material feed system comprising a first circulation circuit and a second circulation circuit, the first circulation circuit fluidly coupled between the second circulation circuit and the print assembly.

Abstract: The present invention relates to a hair straightening apparatus having two arms pivotably coupled together and a heating plate on a facing side of at least one arm. A central pack disposed between the first arm and the second arm and coupled to the hair styling apparatus at the hinge end and a biasing means adapted to support the central pack symmetrically between the first arm and the second arm.

Abstract: A sole for an article of footwear includes an outsole that has longitudinal ribs and a midsole that is disposed above the outsole and that defines notches. The longitudinal ribs arc disposed in the notches.

Abstract: An example method of enforcing granular access policy for embedded artifacts comprises: detecting an association of an embedded artifact with a resource container; associating the embedded artifact with at least a subset of an access control policy associated with the resource container; and responsive to receiving an access request to access the embedded artifact, applying the access control policy associated with the resource container for determining whether the access request is grantable.

Abstract: Systems and methods for making and delivering personalized, medically prescribed pharmaceuticals to an individual patient are described. Individual unit doses (IUDs) of medicine may be prepared specific to the individual in need of same, by using a system, which includes a networked control system in combination with manufacturing assemblies specific to the IUDs and delivering the medicine to the patient directly from the manufacturer.

Abstract: The present invention provides a computer-implemented method for estimating the cancer cell fraction (CCF) of at least one tumour-specific mutation in a subject. Also provided are related methods for monitoring the clonal dynamics of a tumour, monitoring a treatment of the tumour and methods for treating a subject having a cancer, as well as systems for implementing the methods of the invention.

Abstract: A sole for an article of footwear includes an outsole that has longitudinal ribs and a midsole that is disposed above the outsole and that defines notches. The longitudinal ribs are disposed in the notches.

Abstract: The present disclosure relates to systems and methods for tracking content across multiple content outlets. Content items, characterized by first metadata, and content slots, characterized by second metadata, can be received. Third metadata for digital content slots can be generated. Fourth metadata can be received. A recommended content item package can be provided based on a comparison between a combination of the first metadata, the second metadata, and the third metadata and the fourth metadata. The recommended content item package can include a content file and a metadata file. A performance and a measurement of the recommended content item package can be determined by executing the metadata file to track the content file across one or more of the content slots and the potential digital content slots. The performance and the measurement can be provided.

Abstract: Sleep conditions such as sleep apnea can be assessed using a multi-night assessments. A respiration signal (e.g., acquired from a sensor strip) can be processed via a computing device. The respiration signal can be segmented and the segments can be classified to identify one or more apnea/hypopnea events. In some examples, some of the segments can be normalized such that each segment input for classification can be of the same size. The identified one or more apnea/hypopnea events can be used to estimate a nightly parameter indicative of a severity of (or presence of) sleep apnea. The nightly parameters from a multi-night period can be used to estimate a multi-night parameter indicative of the severity of (or presence of) sleep apnea. In some examples, quality checks can be performed to filter out some data (e.g., to exclude data from entire nights or exclude a portion of data from individual nights).

Abstract: An example method of enforcing granular access policy for embedded artifacts comprises: detecting an association of an embedded artifact with a resource container; associating the embedded artifact with at least a subset of an access control policy associated with the resource container; and responsive to receiving an access request to access the embedded artifact, applying the access control policy associated with the resource container for determining whether the access request is grantable.

Abstract: The present disclosure relates to systems and methods for tracking content across multiple content outlets. Content items, characterized by first metadata, and content slots, characterized by second metadata, can be received. Third metadata for digital content slots can be generated. Fourth metadata can be received. A recommended content item package can be provided based on a comparison between a combination of the first metadata, the second metadata, and the third metadata and the fourth metadata. The recommended content item package can include a content file and a metadata file. A performance and a measurement of the recommended content item package can be determined by executing the metadata file to track the content file across one or more of the content slots and the potential digital content slots. The performance and the measurement can be provided.

Abstract: Pharmaceutical compositions having enhanced active component permeation properties are described.

Abstract: The present disclosure relates to systems and methods for tracking content across multiple content outlets. Content items, characterized by first metadata, and content slots, characterized by second metadata, can be received. Third metadata for digital content slots can be generated. Fourth metadata can be received. A recommended content item package can be provided based on a comparison between a combination of the first metadata, the second metadata, and the third metadata and the fourth metadata. The recommended content item package can include a content file and a metadata file. A performance and a measurement of the recommended content item package can be determined by executing the metadata file to track the content file across one or more of the content slots and the potential digital content slots. The performance and the measurement can be provided.

Abstract: Pharmaceutical compositions of epinephrine and its prodrugs are described, the prodrugs having a half-life of less than one minute, and the compositions having enhanced active component permeation properties are described.

Abstract: Sleep conditions such as moderate-to-severe sleep apnea can be assessed using a multi-night assessments. A respiration signal (e.g., acquired from a sensor strip) can be processed via a computing device. The respiration signal can be segmented and the segments can be classified to identify one or more apnea/hypopnea events. In some examples, some of the segments can be normalized such that each segment input for classification can be of the same size. The identified one or more apnea/hypopnea events can be used to estimate a nightly parameter indicative of a severity of (or presence of) sleep apnea. The nightly parameters from a multi-night period can be used to estimate a multi-night parameter indicative of the severity of (or presence of) sleep apnea. In some examples, quality checks can be performed to filter out some data (e.g., to exclude data from entire nights or exclude a portion of data from individual nights).

Abstract: The present disclosure relates to systems and methods for enhancing data from disjunctive sources using a weighted interaction graph. First data about first entities can be received from a first data source. Second data about second entities at least partially different than the first entities can be received from a second data source. Relationships between each entity of the first entities and second entities can be determined, and a set of classes can be inferred from the first data and from the second data. A weighted interaction graph can be generated. The weighted interaction graph can indicate a likelihood of each entity interacting with a corresponding class. An extended set of data can be generated using the weighted interaction graph. The extended set of data can be output to facilitate communication with third entities that include the first entities and the second entities.

Abstract: Systems and methods for making and delivering personalized, medically prescribed pharmaceuticals to an individual patient are described. Individual unit doses (IUDs) of medicine may be prepared specific to the individual in need of same, by using a system, which includes a networked control system in combination with manufacturing assemblies specific to the IUDs and delivering the medicine to the patient directly from the manufacturer.

Abstract: Pharmaceutical compositions of epinephrine and its prodrugs are described and the compositions having enhanced active component permeation properties are described as being administered with specific residence times.