Abstract: Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting KRAS activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with KRAS activity such as cancer.

Abstract: A valved holding chamber includes a holding chamber adapted to contain a substance and having an input end adapted to receive a dry powder inhaler, an output end and an interior volume defined between the input end and output end. An inhalation valve is disposed at the output end of the holding chamber and is moveable to an open position in response to an inhalation flow through the interior space. A vacuum generator, expandable volume and/or positive pressure may be used to draw medication from the dry powder inhaler into the holding chamber. Methods of using and assembling the system are also provided.

Abstract: Content creation techniques are described that leverage content analytics to provide insight and guidance as part of content creation. To do so, content features are extracted by a content analytics system from a plurality of content and used by the content analytics system as a basis to generate a content dataset. Event data is also collected by the content analytics system from an event data source. Event data describes user interaction with respective items of content, including subsequent activities in both online and physical environments. The event data is then used to generate an event dataset. An analytics user interface is then generated by the content analytics system using the content dataset and the event dataset and is usable to guide subsequent content creation and editing.

Abstract: Content creation techniques are described that leverage content analytics to provide insight and guidance as part of content creation. To do so, content features are extracted by a content analytics system from a plurality of content and used by the content analytics system as a basis to generate a content dataset. Event data is also collected by the content analytics system from an event data source. Event data describes user interaction with respective items of content, including subsequent activities in both online and physical environments. The event data is then used to generate an event dataset. An analytics user interface is then generated by the content analytics system using the content dataset and the event dataset and is usable to guide subsequent content creation and editing.

Abstract: Method for recycling printed plastic articles without contaminating or staining the recycled plastic with color due the printed ink. The ink is a water-based composition comprising select self-crosslinking acrylate copolymers or polyurethane resins, which inks exhibit good adhesion under conditions of use, but which are readily removed as solid particles when exposed to a hot caustic solution. Due to the inks being removed as solid particles, and not dissolving into the ink, the recycled plastic remains uncontaminated by the ink during recycling.

Abstract: The present invention provides a printing ink or coating composition comprising a self-crosslinking acrylic polymer and a silicone emulsion wherein the self-crosslinking acrylic polymer has a minimum film forming temperature of less than 25° C. Furthermore, the present invention also provides a process for preparing a coated substrate, in particular a polyboard substrate, and an article made from the coated substrate, such as a milk or juice carton.

Abstract: Systems, methods, and computer-program products can perform task-based management of a mine site. The systems, methods, and computer-program products can create, from and for immutable jobs of an imported plan, ranked tasks to be performed at the mine site; and assign tasks falling within a defined window of time to be performed by work machines at the mine site. The assignment of the tasks can be output on a specialized operator interface. Generally, the tasks can be assigned such that as many tasks as possible are scheduled to be completed by a predetermined time.

Abstract: Systems, apparatuses and methods may provide for technology that initiates one or more optical pulses in accordance with a first emission pattern, obtains a second emission pattern in response to one or more of a time-variable trigger or a deviation of one or more received optical reflections from an expected reflection pattern, and initiates one or more optical pulses in accordance with the second emission pattern. Moreover, infrastructure node technology may detect, based on an interference notification from a first sensor platform, a deviation of received optical reflection(s) from an expected reflection pattern, select emission parameter(s) in response to the deviation, and alter a first emission pattern with respect to the selected emission parameter(s) to obtain a second emission pattern.

Abstract: Known georeferencing techniques require input in the form of manually-chosen anchor points or dense surveyed data. The present invention is an improved method and system for georeferencing underground geometric data. The method comprises (a) visiting at least two control points; (b) obtaining information about each of the at least two control points using scanning means; (c) recording the information about the at least two control points into a computer processor; and (d) performing a best-fit transformation to the recorded information. Preferably, the scanning means comprises laser scanners and at least two radio-frequency identification (RFID) tags. However, other technologies, such as retro-reflective LIDAR targets, Wi-Fi access points or bar codes and a bar code reader may also be used. In addition, sonar, radar, flash LIDAR, MEMS LIDAR, or any other similar technology could be used.

Abstract: There is provided a system including a processor and a memory, storing an asset-data synthesis unit having a data translation module and a data integration module. The processor executes the asset-data synthesis unit to receive a first and a second domain specific asset description data being expressed using different descriptive vocabularies, translate the first and second domain specific asset description data to a common descriptive vocabulary to produce respective first and second common format asset description data, inferentially identify based on probabilistic inference that the first and second common format asset description data describe a same asset, integrate the first and second common format asset description data to produce an integrated asset description data describing the same asset, and generate a synthesized data describing the same asset and linking the integrated asset description data and the first and second domain specific asset description data.

Abstract: According to examples, an apparatus may include a processor to address a physical memory having memory sections, in which a first set of memory sections may be shared between processes and a second set of memory sections may be specific to an individual process. The apparatus may also include a shared virtual address space register to provide translation for the first set of memory sections shared between processes and a process virtual address space register to provide translation for the second set of memory sections specific to the individual process. The translation for the second set of memory sections may be independent from the translation for the first set of memory sections.

Abstract: According to examples, an apparatus may include a processor to address a physical memory having memory sections, in which a first set of memory sections may be shared between processes and a second set of memory sections may be specific to an individual process. The apparatus may also include a shared virtual address space register to provide translation for the first set of memory sections shared between processes and a process virtual address space register to provide translation for the second set of memory sections specific to the individual process. The translation for the second set of memory sections may be independent from the translation for the first set of memory sections.

Abstract: Computerized systems and methods are provided for generating and providing augmented video content to viewers. In one implementation, a media player executed by a user device obtains playlist data identifying underlying video content and elements of overlay content. The media player may generate augmented video content by merging an element of the overlay content into the underlying video content at a temporal position within the underlying video content that is relevant to the overlay content element, and further, may present the augmented video content to a viewer. The media player may detect a triggering event during the presentation of the augmented video content, and may modify the augmented video content in response to the triggering event.

Abstract: Computerized systems and methods are provided for generating and providing augmented video content to viewers. In one implementation, a media player executed by a user device obtains playlist data identifying underlying video content and elements of overlay content. The media player may generate augmented video content by merging an element of the overlay content into the underlying video content at a temporal position within the underlying video content that is relevant to the overlay content element, and further, may present the augmented video content to a viewer. The media player may detect a triggering event during the presentation of the augmented video content, and may modify the augmented video content in response to the triggering event.

Abstract: Systems, apparatuses and methods may provide for technology that initiates one or more optical pulses in accordance with a first emission pattern, obtains a second emission pattern in response to one or more of a time-variable trigger or a deviation of one or more received optical reflections from an expected reflection pattern, and initiates one or more optical pulses in accordance with the second emission pattern. Moreover, infrastructure node technology may detect, based on an interference notification from a first sensor platform, a deviation of received optical reflection(s) from an expected reflection pattern, select emission parameter(s) in response to the deviation, and alter a first emission pattern with respect to the selected emission parameter(s) to obtain a second emission pattern.

Abstract: There is provided a system including a processor and a memory, storing an asset-data synthesis unit having a data translation module and a data integration module. The processor executes the asset-data synthesis unit to receive a first and a second domain specific asset description data being expressed using different descriptive vocabularies, translate the first and second domain specific asset description data to a common descriptive vocabulary to produce respective first and second common format asset description data, inferentially identify based on probabilistic inference that the first and second common format asset description data describe a same asset, integrate the first and second common format asset description data to produce an integrated asset description data describing the same asset, and generate a synthesized data describing the same asset and linking the integrated asset description data and the first and second domain specific asset description data.

Abstract: There are provided asset-data integration systems and methods for use by such systems. Such a system includes a hardware processor, a system memory, and an asset-data synthesis unit including a data translation module and a data integration module, stored in the system memory. The system is configured to receive domain specific asset description data expressed using different descriptive vocabularies, and to translate the domain specific asset description data to produce common format asset description data. The system is further configured to identify the common format asset description data describing the same asset, to integrate that common format asset description data to produce an integrated asset description data describing the asset, and to generate a synthesized data describing the asset and linking the integrated asset description data and the domain specific asset description data.

Abstract: Known georeferencing techniques require input in the form of manually-chosen anchor points or dense surveyed data. The present invention is an improved method and system for georeferencing underground geometric data. The method comprises (a) visiting at least two control points; (b) obtaining information about each of the at least two control points using scanning means; (c) recording the information about the at least two control points into a computer processor; and (d) performing a best-fit transformation to the recorded information. Preferably, the scanning means comprises laser scanners and at least two radio-frequency identification (RFID) tags. However, other technologies, such as retro-reflective LIDAR targets, Wi-Fi access points or bar codes and a bar code reader may also be used. In addition, sonar, radar, flash LIDAR, MEMS LIDAR, or any other similar technology could be used.

Abstract: Various methods, apparatuses and/or articles of manufacture are provided which may be implemented using one or more fixed electronic devices to generate a reference data report corresponding to a particular environment. Various methods, apparatuses and/or articles of manufacture are provided which may be implemented using one or more mobile electronic devices to generate an environment report corresponding to a particular environment.