Abstract: Provided herein are materials and methods for the preparation of blood products. In one aspect, provided herein is a composition including platelets or platelet derivatives and an aqueous medium, wherein the aqueous medium has a protein concentration less than 50% of the protein concentration of donor apheresis plasma.

Abstract: Provided herein are materials and methods for the preparation of blood products. In one aspect, provided herein is a composition including platelets or platelet derivatives and an aqueous medium, wherein the aqueous medium has a protein concentration less than 50% of the protein concentration of donor apheresis plasma.

Abstract: Provided herein are materials and methods for the preparation of blood products. In one aspect, provided herein is a composition including platelets or platelet derivatives and an aqueous medium, wherein the aqueous medium has a protein concentration less than 50% of the protein concentration of donor apheresis plasma.

Abstract: Methods and compositions for estimating one or more downhole qualities of a drilling apparatus by obtaining axial acceleration data. The axial acceleration data may be acquired by measuring an axial acceleration of a bottom hole assembly. The axial acceleration may then be used to estimate one or more of a downward weight on a drill bit of the drilling apparatus or a rate of penetration of the drill bit.

Abstract: Provided herein are materials and methods for the preparation of blood products. In one aspect, provided herein is a composition including platelets or platelet derivatives and an aqueous medium, wherein the aqueous medium has a protein concentration less than 50% of the protein concentration of donor apheresis plasma.

Abstract: Provided herein are materials and methods for the preparation of blood products. In one aspect, provided herein is a composition including platelets or platelet derivatives and an aqueous medium, wherein the aqueous medium has a protein concentration less than 50% of the protein concentration of donor apheresis plasma.

Abstract: Provided herein are materials and methods for the preparation of blood products. In some aspects, provided herein are compositions that include populations of platelet derivatives, including freeze-dried platelet derivatives, methods of producing the same, as well as methods of using the same to treat a subject. Such platelet derivatives have improved properties, as disclosed herein.

Abstract: Provided herein are methods and compositions using extracellular vesicles derived from fresh, frozen, or lyophilized platelets.

Abstract: Provided herein are materials and methods for the preparation of blood products. In one aspect, provided herein is a composition including platelets or platelet derivatives and an aqueous medium, wherein the aqueous medium has a protein concentration less than 50% of the protein concentration of donor apheresis plasma.

Abstract: A method for file system reorganization in the presence of inline compression includes obtaining a virtual block pointer for an original compressed segment to be reorganized, the original compressed segment comprising compressed allocation units of data stored in a storage system, wherein the virtual block pointer comprises an extent list identifying the compressed allocation units in the original compressed segment and a pointer to where the original compressed segment is stored; copying only the referenced compressed allocation units in the original compressed segment to a new compressed segment in a substantially contiguous manner; updating the extent list to identify the referenced compressed allocation units in the new compressed segment, and the pointer to where the new compressed segment is stored; and freeing the original compressed segment.

Abstract: Provided herein are methods and compositions for treating a coagulopathy in a subject. Such methods can include administering to the subject in need thereof, for example because they have been administered an anticoagulant agent, an effective amount of a composition including platelets, or in illustrative embodiments platelet derivatives, and in further illustrative embodiments freeze-dried platelet derivatives (FDPDs). Various properties of exemplary embodiments of such methods and platelet derivatives used therein, as well as numerous additional aspects and embodiments are provided herein.

Abstract: Provided herein are methods and compositions for treating a coagulopathy in a subject. Such methods can include administering to the subject in need thereof, for example because they have been administered an anticoagulant agent, an effective amount of a composition including platelets, or in illustrative embodiments platelet derivatives, and in further illustrative embodiments freeze-dried platelet derivatives (FDPDs). Various properties of exemplary embodiments of such methods and platelet derivatives used therein, as well as numerous additional aspects and embodiments are provided herein.

Abstract: Ferrules, alignment frames and connectors having at least one flexing element are provided. A ferrule or an alignment frame may include a body and first and second flexible arms, and a connector may include the ferrule or the alignment frame. A ferrule may have a first flexible arm that has a first fixed end attached to a first side of the body of the ferrule and an opposite first free end, and may have a second flexible arm having a second fixed end attached to a second side of the body, opposite the first side, and an opposite second free end. When the ferrule is mated with a mating ferrule, the first and second flexible arms are flexed away from the respective first and second sides of the body, and the first and second free ends contact the mating ferrule.

Abstract: Ferrules, alignment frames and connectors having at least one flexing element are provided. A ferrule or an alignment frame may include a body and first and second flexible arms, and a connector may include the ferrule or the alignment frame. A ferrule may have a first flexible arm that has a first fixed end attached to a first side of the body of the ferrule and an opposite first free end, and may have a second flexible arm having a second fixed end attached to a second side of the body, opposite the first side, and an opposite second free end. When the ferrule is mated with a mating ferrule, the first and second flexible arms are flexed away from the respective first and second sides of the body, and the first and second free ends contact the mating ferrule.

Abstract: A method for calibrating a steering model may comprise estimating an initial condition for one or more variables in the steering model and calibrating the steering model with a Markov Chain Monte Carlo Simulation (MCMC). A drilling system may comprise a bottom hole assembly, a drill string connected to the bottom hole assembly, and an information handling system connected to the bottom hole assembly. The information handling system may be configured to process one or more measurements from the bottom hole assembly, calibrate a steering model based at least in part on the one or more measurements, adjust a control logic based at least in part on the steering model, and adjust the bottom hole assembly based at least in part on the control logic.

Abstract: Provided herein are materials and methods for the preparation of blood products. In one aspect, provided herein is a composition including platelets or platelet derivatives and an aqueous medium, wherein the aqueous medium has a protein concentration less than 50% of the protein concentration of donor apheresis plasma.

Abstract: Ferrules, alignment frames and connectors having at least one flexing element are provided. A ferrule or an alignment frame may include a body and first and second flexible arms, and a connector may include the ferrule or the alignment frame. A ferrule may have a first flexible arm that has a first fixed end attached to a first side of the body of the ferrule and an opposite first free end, and may have a second flexible arm having a second fixed end attached to a second side of the body, opposite the first side, and an opposite second free end. When the ferrule is mated with a mating ferrule, the first and second flexible arms are flexed away from the respective first and second sides of the body, and the first and second free ends contact the mating ferrule.

Abstract: An improved technique involves providing file system shrink capability by shrinking the size of the volume file in which an upper deck file system is stored. Along these lines, a data storage system, upon receiving a request to shrink an upper deck file system, determines a new address in the upper deck file system, based on an amount the upper deck file system is to be shrunk, to which the end-of-file (EOF) pointer of the volume file will point. The new address will have a smaller distance from the address of the file pointer than the original address to which the EOF pointer points. The data storage system then identifies nonempty data blocks of the upper deck file system that have logical addresses having a larger distance from the address of the file pointer than the second logical address.

Abstract: An improved technique for managing data storage includes relocating allocated blocks within a range of a physical address space of a file system to free the allocated blocks. The range has a length equal to a length of one or more full stripes of a RAID group that stores content of the file system. In response to receiving data to be written to the file system, the file system arranges the data in the range of contiguous blocks and performs one or more full-stripe writes to write the data to the RAID group.

Abstract: Techniques for shrinking a filesystem backed by a volume identify slices in the volume to be evacuated in order to reach a target size, identify a target endpoint in the volume, and evacuate identified slices to available locations prior to the target endpoint. The same data is typically not moved from slice to slice multiple times.