Abstract: Provided herein are methods and compositions for treating a coagulopathy in a subject. Such methods can include administering to the subject in need thereof, for example because they have been administered an anticoagulant agent, an effective amount of a composition including platelets, or in illustrative embodiments platelet derivatives, and in further illustrative embodiments freeze-dried platelet derivatives (FDPDs). Various properties of exemplary embodiments of such methods and platelet derivatives used therein, as well as numerous additional aspects and embodiments are provided herein.

Abstract: Provided herein are methods and compositions for treating a coagulopathy in a subject. Such methods can include administering to the subject in need thereof, for example because they have been administered an anticoagulant agent, an effective amount of a composition including platelets, or in illustrative embodiments platelet derivatives, and in further illustrative embodiments freeze-dried platelet derivatives (FDPDs). Various properties of exemplary embodiments of such methods and platelet derivatives used therein, as well as numerous additional aspects and embodiments are provided herein.

Abstract: Aspects of the subject technology relate to systems and methods of controlling a drill string having a steerable bit when drilling a wellbore through a substrate. A deterministic model of a directional behavior of the drill string is developed that includes a drill string state, one or more drill parameters associated with the drill string, and one or more substrate parameters associated with the substrate. A stochastic differential model of the directional behavior of the drill string is then developed by replacing the state and each of the parameters of the deterministic model with respective probability distributions and adding feedback. The stochastic differential model is reduced to a truncated stochastic model by substituting a predetermined number of terms of a generalized polynomial chaos expansion for each probability distribution and then evaluating the expectations.

Abstract: Methods and compositions for estimating one or more downhole qualities of a drilling apparatus by obtaining axial acceleration data. The axial acceleration data may be acquired by measuring an axial acceleration of a bottom hole assembly. The axial acceleration may then be used to estimate one or more of a downward weight on a drill bit of the drilling apparatus or a rate of penetration of the drill bit.

Abstract: Provided herein are materials and methods for the preparation of blood products. In one aspect, provided herein is a composition including platelets or platelet derivatives and an aqueous medium, wherein the aqueous medium has a protein concentration less than 50% of the protein concentration of donor apheresis plasma.

Abstract: Provided herein are materials and methods for the preparation of blood products. In one aspect, provided herein is a composition including platelets or platelet derivatives and an aqueous medium, wherein the aqueous medium has a protein concentration less than 50% of the protein concentration of donor apheresis plasma.

Abstract: Provided herein are materials and methods for the preparation of blood products. In one aspect, provided herein is a composition including platelets or platelet derivatives and an aqueous medium, wherein the aqueous medium has a protein concentration less than 50% of the protein concentration of donor apheresis plasma.

Abstract: Methods and compositions for estimating one or more downhole qualities of a drilling apparatus by obtaining axial acceleration data. The axial acceleration data may be acquired by measuring an axial acceleration of a bottom hole assembly. The axial acceleration may then be used to estimate one or more of a downward weight on a drill bit of the drilling apparatus or a rate of penetration of the drill bit.

Abstract: Provided herein are materials and methods for the preparation of blood products. In one aspect, provided herein is a composition including platelets or platelet derivatives and an aqueous medium, wherein the aqueous medium has a protein concentration less than 50% of the protein concentration of donor apheresis plasma.

Abstract: A method for file system reorganization in the presence of inline compression includes obtaining a virtual block pointer for an original compressed segment to be reorganized, the original compressed segment comprising compressed allocation units of data stored in a storage system, wherein the virtual block pointer comprises an extent list identifying the compressed allocation units in the original compressed segment and a pointer to where the original compressed segment is stored; copying only the referenced compressed allocation units in the original compressed segment to a new compressed segment in a substantially contiguous manner; updating the extent list to identify the referenced compressed allocation units in the new compressed segment, and the pointer to where the new compressed segment is stored; and freeing the original compressed segment.

Abstract: A method for calibrating a steering model may comprise estimating an initial condition for one or more variables in the steering model and calibrating the steering model with a Markov Chain Monte Carlo Simulation (MCMC). A drilling system may comprise a bottom hole assembly, a drill string connected to the bottom hole assembly, and an information handling system connected to the bottom hole assembly. The information handling system may be configured to process one or more measurements from the bottom hole assembly, calibrate a steering model based at least in part on the one or more measurements, adjust a control logic based at least in part on the steering model, and adjust the bottom hole assembly based at least in part on the control logic.

Abstract: Provided herein are materials and methods for the preparation of blood products. In one aspect, provided herein is a composition including platelets or platelet derivatives and an aqueous medium, wherein the aqueous medium has a protein concentration less than 50% of the protein concentration of donor apheresis plasma.

Abstract: An improved technique involves providing file system shrink capability by shrinking the size of the volume file in which an upper deck file system is stored. Along these lines, a data storage system, upon receiving a request to shrink an upper deck file system, determines a new address in the upper deck file system, based on an amount the upper deck file system is to be shrunk, to which the end-of-file (EOF) pointer of the volume file will point. The new address will have a smaller distance from the address of the file pointer than the original address to which the EOF pointer points. The data storage system then identifies nonempty data blocks of the upper deck file system that have logical addresses having a larger distance from the address of the file pointer than the second logical address.

Abstract: An improved technique for managing data storage includes relocating allocated blocks within a range of a physical address space of a file system to free the allocated blocks. The range has a length equal to a length of one or more full stripes of a RAID group that stores content of the file system. In response to receiving data to be written to the file system, the file system arranges the data in the range of contiguous blocks and performs one or more full-stripe writes to write the data to the RAID group.

Abstract: Techniques for shrinking a filesystem backed by a volume identify slices in the volume to be evacuated in order to reach a target size, identify a target endpoint in the volume, and evacuate identified slices to available locations prior to the target endpoint. The same data is typically not moved from slice to slice multiple times.

Abstract: A data storage system tracks liability and insurance for an internal file system, liability being a number of slices needed to store file system data, insurance being a number of slices allowed to be consumed. A reserve of un-provisioned insurance is maintained from which slices are provisioned to the file system for use in storing file system data without immediate requirement for increasing the insurance. Slices are provisioned to the file system from the reserve of un-provisioned insurance based on a window criteria and a space criteria, the window criteria being that a number of free windows is less than a free window threshold, the space criteria being that a number of currently provisioned slices is less than a maximum allowed slices, which includes an overprovisioning factor applied to the primary file size to allow for growth of the primary file without immediate requirement for increasing provisioned insurance.

Abstract: A technique for managing transaction logging of file system metadata in a data storage system stores metadata transactions for multiple file systems of the data storage system in respective log files, such that each log file stores metadata transactions for a single file system only. The data storage system thus provides transaction log files on a per-file-system basis.

Abstract: A technique for managing file systems assigns groups of related files in a file system to respective version sets. Each version set includes all files of a file system that are related to one another by one or more snapshot operations. The technique provides a version set database, which stores, in connection with each version set, an identifier of each file that belongs to the respective version set. In an example, file system operations that require information about block sharing can perform lookup operations on the version set database to narrow the scope of files that are candidates for block sharing to those of a particular version set.

Abstract: A technique for storing support files in a data storage apparatus provides auxiliary files in a container file system. The container file system stores a container file that provides a file-based realization of a data object, such as an entire file system, LUN, or vVOL, for example, and stores one or more auxiliary files in the container file system alongside the container file. Thus, an auxiliary file that supports an application program's operations on a data object resides in the same fault domain with the container file that realizes the data object.

Abstract: Reclaiming storage from a file system hosting of storage objects includes assigning objects and respective files to version sets, each version set containing a primary object and respective snapshots. Each block of storage is associated with the version set of the file(s) that contain the block. Blocks residing in an extent that is to be reclaimed are identified, and for each block (i) an offset is obtained that specifies a location of the block in a file, (ii) files whose objects are assigned to the version set associated with the block are identified, (iii) a block pointer at the location in each of the identified underlying files is examined, and for each file whose block pointer points to the block, updating the block pointer to point to a new block location outside of the extent, to which the block is moved.