Patents by Inventor Alexander Michael Real

Alexander Michael Real has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SMALL MOLECULE MODULATORS OF KSR-BOUND MEK
    Publication number: 20230381180
    Abstract: An ATP non-competitive inhibitor of mitogen-activated protein kinase (MEK), inter alia, human MEK (MEK1 or MEK2) having the properties: (i) allosterically binds an inhibitor pocket formed at an interaction interface between human MEK (MEK1 or MEK2) and human Kinase Suppressor of Ras (KSR1 or KSR2 or BRAF) adjacent to ATP in a physiological complex between MEK and KSR (or BRAF), forming an inhibitor-inhibitor pocket complex; (ii) is an ATP non-competitive kinase inhibitor; (iii) a structure such that when bound to the inhibitor-inhibitor pocket complex, the complex comprises the structural elements: (a) at least one moiety of the inhibitor engaging A825 of KSR1, or P878 of KSR2; or R662 of BRAF (b) at least one moiety engaging R234 of MEK, wherein where R234 is within 5 ? from any atoms of KSR1 or KSR2 or BRAF is disclosed.
    Type: Application
    Filed: January 8, 2021
    Publication date: November 30, 2023
    Inventors: Arvin Dar, Alexander P. Scopton, Jayasudhan Reddy Yerabolu, Zaigham M. Khan, Alexander Michael Real, William Michael Marsiglia