Abstract: The invention relates to a polymorphic form of (S)-3-(3-(1-methyl-2-oxo-5-(pyrazolo[1,5-a]pyridine-3-yl)-1H-imidazo[4,5-b]pyridine-3(2H)-yl)piperidin-1-yl)-3-oxopropanenitrile and use as a therapeutic agent for the treatment of respiratory diseases.

Abstract: The invention relates to a polymorphic form of (S)-3-(3-(1-methyl-2-oxo-5-(pyrazolo[1,5-a]pyridine-3-yl)-1H-imidazo[4,5-b]pyridine-3(2H)-yl)piperidin-1-yl)-3-oxopropanenitrile and use as a therapeutic agent for the treatment of respiratory diseases.

Abstract: The invention relates to a polymorphic forms of (S)-3-(3-(1-methyl-2-oxo-5-(pyrazolo[1,5-a]pyridine-3-yl)-1H-imidazo[4,5-b]pyridine-3(2H)-yl)piperidin-1-yl)-3-oxopropanenitrile and their use as a therapeutic agent for the treatment of respiratory diseases.

Abstract: The invention relates to a polymorphic forms of (S)-3-(3-(1-methyl-2-oxo-5-(pyrazolo[1,5-a]pyridine-3-yl)-1H-imidazo[4,5-b]pyridine-3(2H)-yl)piperidin-1-yl)-3-oxopropanenitrile and their use as a therapeutic agent for the treatment of respiratory diseases.

Abstract: A method and apparatus for filtering fuel in a motor vehicle includes a cyclonic fuel filter, the cyclonic filter including a housing having a body forming a cyclone chamber defined by walls of the body. The body includes an inlet to receive fuel and an outlet to transport fuel away from the cyclonic fuel filter after it has been processed. The cyclonic fuel filter further includes a receptacle to receive particulates filtered from the fuel. Fuel introduced into the inlet, travels along the inner wall in a cyclical circular pattern, subjecting it to centrifugal forces as it rotates. The centrifugal forces cause heavier particulates to travel outward against the walls of the cyclonic fuel filter, and the force of gravity causes those particulates to move down the wall to be received within the receptacle at the bottom of the cyclonic filter. Filtered fuel exits through an outlet at the top of the body of the cyclonic filter.

Abstract: An intraoral imaging system includes a receiving module that communicates with an imaging display device. The imaging device includes handle having a transmitter module and a power source as well as neck and head portions that extend from the handle. The device includes a camera module that rotates in the distal and proximal direction to view and process still images and video. The camera module includes a movable image sensor to provide focus capability. The imaging device further includes a control assembly having a plurality of control members. The control assembly includes image capture controls that an operator engages in a lateral motion to capture images or video. A focus control member controls the spatial relationship between the image sensor and the stationary lens and an articulation control member to articulate the camera module to provide a greater range of imaging.

Abstract: The present invention relates to new compounds of formula I, (I) wherein R1 to R4, m, n and p, are as defined as in formula I, or salts, solvates or solvated salts thereof, processes for their preparation and to a new intermediate used in the preparation thereof, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy.

Abstract: The present invention relates to new compounds, or salts, solvates or solvated salts thereof, processes for their preparation and to new intermediates used in the preparation thereof, pharmaceutical compositions containing said compounds and to the use of said compounds in therapy.

Abstract: Compounds of formula I, wherein R1, n, R3, R4, R7, R8 and P are as defined in the specification, salts, solvates or solvated salts thereof, processes for their preparation, new intermediates used in the preparation thereof, pharmaceutical compositions containing said compounds and the use of said compounds in therapy.

Abstract: Methods of treating an elastomeric MDI sealing gasket that include washing the gasket in an alkali wash solution that is a solution of an alkali metal hydroxide in water are disclosed. Metering valves, containers, metered dose inhalers, and drug products that include such gaskets are also disclosed, as are methods of using such gaskets.

Abstract: A body part including a surface having a fluid flow thereover. The body part also includes flocking coupled to at least a portion of the surface that adjusts an aerodynamic characteristic relative to the surface that is devoid of the flocking.

Abstract: Continuous multifilament glass fiber roving of from 300 to 10,000 tex is rendered catenary-free without twisted by passing it at from 150 to 300 meters/minute through an air treatment zone in which it is exposed to air at from 400 to 600 KN/meter.sup.2 at a volume throughput of from 0.5 to 1.5 cubic meters/minute, the air treatment being carried out in the absence of positive overfeed whereby there is no bulking of the roving, followed by winding the treated roving into a package.