Patents by Inventor Alexander Pretsch
Alexander Pretsch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11013760Abstract: Polyguanidines and methods of use thereof are described. In particular, polyguanidines of formula (I), formula (II), and formula (III) are described. The polyguanidines can be used to treat infection, such as bacterial, viral or fungal infection, and as an ex vivo microbial agent.Type: GrantFiled: May 14, 2019Date of Patent: May 25, 2021Assignee: SEALIFE PHARMA GMBHInventors: Alexander Pretsch, Michael Nagl, Christoph Wiesner, Ralph Hollaus, Miroslav Genov
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Publication number: 20190269719Abstract: Polyguanidines and methods of use thereof are described. In particular, polyguanidines of formula (I), formula (II), and formula (III) are described. The polyguanidines can be used to treat infection, such as bacterial, viral or fungal infection, and as an ex vivo microbial agent.Type: ApplicationFiled: May 14, 2019Publication date: September 5, 2019Inventors: Alexander PRETSCH, Michael NAGL, Christoph WIESNER, Ralph HOLLAUS, Miroslav GENOV
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Patent number: 10376537Abstract: Disclosed herein is a method of reducing the risk of a rhinovirus infection, the method includes administering to a subject a composition comprising iota-carrageenan in an antiviral effective amount as an active antiviral ingredient.Type: GrantFiled: August 23, 2012Date of Patent: August 13, 2019Assignee: MARINOMED BIOTECH AGInventors: Andreas Grassauer, Eva Prieschl-Grassauer, Christiane Koller, Alexander Pretsch
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Patent number: 10335431Abstract: A method for preparing polycondensation products of guanidine, aminoguanidine or diaminoguanidine G with one or more benzyl or allyl derivatives BA according to the following reaction scheme is provided: wherein X, R1, Gua, Y and Z are as defined in the specification. In the disclosed method, at least one benzyl or allyl derivative BA is subjected to a polycondensation reaction with excessive guanidine, aminoguanidine or diaminoguanidine G upon elimination of HX.Type: GrantFiled: July 30, 2015Date of Patent: July 2, 2019Assignee: Sealife Pharma GmbHInventors: Alexander Pretsch, Michael Nagl, Christoph Wiesner, Ralph Hollaus, Miroslav Genov
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Publication number: 20170224723Abstract: A method for preparing polycondensation products of guanidine, aminoguanidine or diaminoguanidine G with one or more benzyl or allyl derivatives BA according to the following reaction scheme is provided: wherein X, R1, Gua, Y and Z are as defined in the specification. In the disclosed method, at least one benzyl or allyl derivative BA is subjected to a polycondensation reaction with excessive guanidine, aminoguanidine or diaminoguanidine G upon elimination of HX.Type: ApplicationFiled: July 30, 2015Publication date: August 10, 2017Inventors: Alexander PRETSCH, Michael NAGL, Christoph WIESNER, Ralph HOLLAUS, Miroslav GENOV
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Patent number: 9567294Abstract: Polycondensation products of aminoguanidine and/or 1,3-diaminoguanidine with one or more diamines are provided including polyguanidine derivatives of the following formula (I) or a salt thereof: wherein X is selected from —NH2, aminoguanidino and 1,3-diaminoguanidino; Y is selected from —H and —R1—NH2; or X and Y together represent a chemical bond to give a cyclic structure; R1 is selected from divalent organic radicals having 2 to 20 carbon atoms, in which optionally one or more carbon atoms are replaced by O or N; a and b are each 0 or 1, wherein a+b?2 if no 1,3-diaminoguanidine units are included; R2 is selected from —H and —NH2, wherein R2 is —NH2 if a+b=0, R2 is —H or —NH2 if a+b=1, and R2 is —H if a+b=2; and n?2. Production methods and uses of the polyguanidine derivatives are also provided.Type: GrantFiled: January 22, 2014Date of Patent: February 14, 2017Assignee: Sealife Pharma GmbHInventors: Alexander Pretsch, Michael Nagl, Christoph Wiesner, Heinz Burgmann
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Publication number: 20150368193Abstract: Polycondensation products of aminoguanidine and/or 1,3-diaminoguanidine with one or more diamines are provided including polyguanidine derivatives of the following formula (I) or a salt thereof: wherein X is selected from —NH2, aminoguanidino and 1,3-diaminoguanidino; Y is selected from —H and —R1—NH2; or X and Y together represent a chemical bond to give a cyclic structure; R1 is selected from divalent organic radicals having 2 to 20 carbon atoms, in which optionally one or more carbon atoms are replaced by O or N; a and b are each 0 or 1, wherein a+b?2 if no 1,3-diaminoguanidine units are included; R2 is selected from —H and —NH2, wherein R2 is —NH2 if a+b=0, R2 is —H or —NH2 if a+b=1, and R2 is —H if a+b=2; and n?2. Production methods and uses of the polyguanidine derivatives are also provided.Type: ApplicationFiled: January 22, 2014Publication date: December 24, 2015Inventors: Alexander PRETSCH, Michael NAGL, Christoph WIESNER, Heinz BURGMANN
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Publication number: 20120315311Abstract: Disclosed herein is a method of reducing the risk of a rhinovirus infection, the method includes administering to a subject a composition comprising iota-carrageenan in an antiviral effective amount as an active antiviral ingredient.Type: ApplicationFiled: August 23, 2012Publication date: December 13, 2012Applicant: MARINOMED BIOTECHNOLOGIE GMBHInventors: Andreas GRASSAUER, Eva PRIESCHL-GRASSAUER, Christiane MEIER, Alexander PRETSCH
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Patent number: 8282969Abstract: A method for manufacturing an antiviral pharmaceutical composition for the prophylaxis or treatment of a rhinovirus infection that includes the utilization of iota-, kappa- or lambda-carrageenan or mixtures thereof.Type: GrantFiled: December 4, 2007Date of Patent: October 9, 2012Assignee: Marinomed Biotechnologie GmbHInventors: Andreas Grassauer, Eva Prieschl-Grassauer, Christiane Koller, Alexander Pretsch
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Publication number: 20120129927Abstract: The invention relates to two novel substances, namely (1R,2S,3S,4R)-3-acetoxy-1,2,4,5-tetrahydroxy-7-methoxy-2-methyl-1,2,3,4-tetrahydroanthracene-9,10-dione (3-O-acetyl altersolanol M) and 8-(4,5,6-trihydroxy-7-methyl-2-methoxy-9,10-dioxo-9H,10H-anthracen-1-yl)-(1S,2S,3R,4S)-1,2,3,4,5-pentahydroxy-7-methoxy-2-methyl-1,2,3,4-tetrahydro-9H,10H-anthracene-9,10-dione (the atropisomers alterporriol I and J) to their use as anti-infectives and as anti-cancer agents, as well as to methods of producing the same.Type: ApplicationFiled: May 31, 2010Publication date: May 24, 2012Applicant: SEALIFE PHARMA GMBHInventors: Alexander Pretsch, Peter Proksch, Abdessamad Debbab
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Publication number: 20120129949Abstract: The present invention relates to the use of the following anthracene derivatives as anti-infectives, preferably against multiply drug resistant pathogens: (2R,3S,10R)-2,3,5,10-tetrahydroxy-6-methoxy-3-methyl-1,2,3,4,4a,9a-hexahydro-9H,10H-anthracen-9-one (tetrahydroaltersolanol B), (1R,2R,3R,4aS,9aR,10R)-1,2,3,5,10-pentahydroxy-7-methoxy-2-methyl-1,2,3,4,4a,9a-hexahydro-9H,10H-anthracen-9-one (altersolanol K), (2R,3R,4R,4aS,9aS,10R)-2,3,4,8,10-pentahydroxy-6-methoxy-3-methyl-1,2,3,4,4a,9a-hexahydro-9H,10H-anthracen-9-one (altersolanol L), 8-(1,7-dihydroxy-6-methyl-3-methoxy-9,10-dioxo-9H,10H-anthracen-2-yl)-(1S,2S,3R,4S)-1,2,3,4,5-pentahydroxy-7-methoxy-2-methyl-1,2,3,4-tetrahydro-9H,10H-anthracen-9,10-dione (atropisomers alterporriol G and H); as well as (2R,3S,4aS,9aS,10R)-2,3,5,8,10-pentahydroxy-6-methoxy-3-methyl-1,2,3,4,4a,9a-hexahydro-9H,10H-anthracen-9-one (8-hydroxytetrahydroaltersolanol B).Type: ApplicationFiled: May 31, 2010Publication date: May 24, 2012Applicant: SEALIFE PHARMA GMBHInventors: Alexander Pretsch, Peter Proksch, Abdessamad Debbab
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Publication number: 20100160254Abstract: The present invention provides the use of a polymer for the manufacture of an antiviral pharmaceutical composition for the treatment of a rhinovirus infection, wherein the polymer is cellulose sulfate.Type: ApplicationFiled: March 30, 2007Publication date: June 24, 2010Applicant: MARINOMED BIOTECHNOLOGIE GMBHInventors: Andreas Grassauer, Alexander Pretsch
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Publication number: 20100040658Abstract: A method for manufacturing an antiviral pharmaceutical composition for the prophylaxis or treatment of a rhinovirus infection that includes the utilization of iota-, kappa- or lambda-carrageenan or mixtures thereof.Type: ApplicationFiled: December 4, 2007Publication date: February 18, 2010Applicant: MARINOMED BIOTECHNOLOGIE GMBHInventors: Andreas Grassauer, Eva Prieschl-Grassauer, Christiane Meier, Alexander Pretsch
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Publication number: 20080131454Abstract: The present invention provides the use of carrageenan or mixtures thereof for the manufacture of an antiviral pharmaceutical composition for the treatment of rhinovirus infections.Type: ApplicationFiled: December 5, 2006Publication date: June 5, 2008Applicant: MARINOMED BIOTECHNOLOGIE GMBHInventors: Andreas Grassauer, Eva Prieschl-Grassauer, Christiane Meier, Alexander Pretsch