Abstract: Disclosed is a method of conducting chemical reactions below the diffraction limit. The method comprises providing a composition comprising or consisting of at least one photoenol, initiating a reaction which emanates from the photoenol at a selected site by irradiation with light of a first, photoenol-activating wavelength, and concurrently or thereafter, suppressing the reaction emanating from the photoenol in the immediate vicinity of the selected site by irradiation with light of a second, photoenol-deactivating wavelength which creates an interference pattern having an intensity minimum or zero intensity at the selected site.