Patents by Inventor Alexander R. Neurath
Alexander R. Neurath has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 6727240Abstract: A method of preventing HIV-1 or HIV-2 infection by administering to a human a pharmaceutically effective anti-HIV-1 or anti-HIV-2 amount of a tin or silicon protoporphyrin IX or tin or silicon mesoporphyrin IX, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: October 21, 1994Date of Patent: April 27, 2004Assignee: New York Blood Center, Inc.Inventors: Alexander R. Neurath, Shibo Jiang, Asim Kumar Debnath
-
Patent number: 6462030Abstract: A method for treating or preventing bacterial vaginosis comprising administering to a human female an effective anti-bacterial vaginosis amount of a composition comprising at least one active compound selected from the group consisting of cellulose acetate phthalate and hydroxypropyl methylcellulose phthalate, either alone or in combination with a pharmaceutically acceptable carrier.Type: GrantFiled: June 19, 2000Date of Patent: October 8, 2002Assignee: New York Blood Center, Inc.Inventor: Alexander R. Neurath
-
Patent number: 5620844Abstract: A hepatitis B vaccine containing a peptide with an amino acid chain of at least six consecutive amino acids within the pre-S gene coded region of the envelope of hepatitis B virus. The vaccine being free of an amino acid sequence corresponding to the naturally occurring envelope proteins of hepatitis B virus and a physiologically acceptable diluent. The peptide being free or linked to a carrier. The carrier being a conventional carrier or a novel carrier including a lipid vesicle stabilized by cross-linking and having covalently bonded active sites on the outer surface thereon. Such novel carrier being useful not only to link the novel peptide containing an amino acid chain with amino acids within the pre-S gene coded region of the surface antigen of hepatitis B virus, but can also be used to bind synthetic peptide analogues of other viral proteins, as well as bacterial, allergen and parasitic proteins of man and animals.Type: GrantFiled: May 3, 1993Date of Patent: April 15, 1997Assignees: New York Blood, Inc., California Institute of TechnologyInventors: Alexander R. Neurath, Stephen B. H. Kent
-
Patent number: 5565548Abstract: A hepatitis B vaccine containing a peptide with an amino acid chain of at least six consecutive amino acids within the pre-S gene coded region of the envelope of hepatitis B virus. The vaccine being free of an amino acid sequence corresponding to the naturally occurring envelope proteins of hepatitis B virus and a physiologically acceptable diluent. The peptide being free or linked to a carrier. The carrier being a conventional carrier or a novel carrier including a lipid vesicle stabilized by cross-linking and having covalently bonded active sites on the outer surface thereon. Such novel carrier being useful not only to link the novel peptide containing an amino acid chain with amino acids within the pre-S gene coded region of the surface antigen of hepatitis B virus, but can also be used to bind synthetic peptide analogues of other viral proteins, as well as bacterial, allergen and parasitic proteins of man and animals.Type: GrantFiled: March 15, 1993Date of Patent: October 15, 1996Assignees: New York Blood Center, Inc., California Institute of TechnologyInventors: Alexander R. Neurath, Stephen B. H. Kent
-
Patent number: 5230998Abstract: A method for the rapid screening of a drug targeted to the V3 hypervariable loop of the human immunodeficiency virus type 1 or type 2 envelope glycoprotein gp 120 comprising measuring the inhibitory effect of the drug on the interaction between gp 120 (or an antigen comprising the V3 hypervariable loop of HIV 1 gp 120 or HIV 2 gp 120) and antibodies specific for the V3 hypervariable loop, and anti-HIV chemotherapy with drugs binding to the V3 hypervariable loop.Type: GrantFiled: July 25, 1991Date of Patent: July 27, 1993Inventors: Alexander R. Neurath, Nathan Strick, Paul Haberfield, Shibo Jiang
-
Patent number: 5204096Abstract: A hepatitis B vaccine containing a peptide with an amino acid chain of at least six consecutive amino acids within the pre-S gene coded region of the envelope of hepatitis B virus. The vaccine being free of an amino acid sequence corresponding to the naturally occurring envelope proteins of hepatitis B virus and a physiologically acceptable diluent. The peptide being free or linked to a carrier. The carrier being a conventional carrier or a novel carrier including a lipid vesicle stabilized by cross-linking and having covalently bonded active sites on the outer surface thereon. Such novel carrier being useful not only to link the novel peptide containing an amino acid chain with amino acids within the pre-S gene coded region of the surface antigen or hepatitis B virus, but can also be used to bind synthetic peptide analogues of other viral proteins, as well as bacterial, allergen and parasitic proteins of man and animals.Type: GrantFiled: April 14, 1989Date of Patent: April 20, 1993Assignees: New York Blood Center, Inc., California Institute of TechnologyInventors: Alexander R. Neurath, Stephen B. H. Kent
-
Patent number: 5158769Abstract: A hepatitis B vaccine containing a peptide with an amino acid chain of at least six consecutive amino acids within the pre-S gene coded region of the envelope of hepatitis B virus. The vaccine being free of an amino acid sequence corresponding to the naturally occurring envelope proteins of hepatitis B virus and a physiologically acceptable diluent. The peptide being free or linked to a carrier. The carrier being a conventional carrier or a novel carrier including a lipid vesicle stabilized by cross-linking and having covalently bonded active sites on the outer surface thereon. Such novel carrier being useful not only to link the novel peptide containing an amino acid chain with amino acids within the pre-S gene coded region of the surface antigen of hepatitis B virus, but can also be used to bind synthetic peptide analogues of other viral proteins, as well as bacterial, allergen and parasitic proteins of man and animals.Type: GrantFiled: April 13, 1989Date of Patent: October 27, 1992Assignees: New York Blood Center, Inc., California Institute of TechnologyInventors: Alexander R. Neurath, Stephen B. H. Kent
-
Patent number: 5039522Abstract: An immunogenic complex comprising a peptide containing a hydrophobic tail, the peptide being adsorbed to hepatitis B virus surface antigen via the hydrophobic tail. Such complex in a immunogenically effective amount when administered with a physiologically acceptable diluent and an adjuvant can serve as a vaccine.Type: GrantFiled: January 29, 1988Date of Patent: August 13, 1991Assignee: New York Blood Center, Inc.Inventor: Alexander R. Neurath
-
Patent number: 4877725Abstract: A process for the detection of antibodies to HTLV III/LAV comprising:(A) mixing an unknown serum sample with a crude HTLV III/LAV viral antigen selected from the group consisting of(1) an antigen comprising P24 core protein and Penv protein;(2) a P24 antigen and(3) a Penv antigen,(B) incubating the resultant mixture from step (A);(C) contacting the mixture of step (B) with a solid substrate coated with antibody to HTLV III/LAV;(D) incubating the mass from step (C);(E) washing the mass from step (D);(F) contacting the mass from step (E) with a labeled antibody to HTLV III/LAV;(G) incubating the mass from step (F);(H) washing the mass from step (G);(I) assaying the label in the mass from step (H);(J) as a negative control, mixing a serum sample known to be negative to HTLV III/LAV antibody with a diluent;(K) subjecting the mass from step (J) to steps (B) to (I);(L) as a positive control, mixing a predetermined amount of the crude HTLV III/LAV viral antigen and the diluent;(M) subjecting the mass from step (L) tType: GrantFiled: April 1, 1985Date of Patent: October 31, 1989Assignee: New York Blood Center, Inc.Inventors: Alexander R. Neurath, Nathan Strick
-
Patent number: 4861588Abstract: A hepatitis B vaccine containing a peptide with an amino acid chain of at least six consecutive amino acids within the pre-S gene coded region of the envelope of hepatitis B virus. The vaccine being free of an amino acid sequence corresponding to the naturally occurring envelope proteins of hepatitis B virus and a physiologically acceptable diluent. The peptide being free or linked to a carrier. The carrier being a conventional carrier or a novel carrier including a lipid vesicle stabilized by cross-linking and having covalently bonded active sites on the outer surface thereon. Such novel carrier being useful not only to link the novel peptide containing an amino acid chain with amino acids within the pre-S gene coded region of the surface antigen of hepatitis B virus, but can also be used to bind synthetic peptide analogues of other viral proteins, as well as bacterial, allergen and parasitic proteins of man and animals.Type: GrantFiled: April 28, 1986Date of Patent: August 29, 1989Assignees: New York Blood Center, Inc., California Institute TechnologyInventors: Alexander R. Neurath, Stephen B. H. Kent
-
Patent number: 4847080Abstract: A hepatitis B vaccine containing a peptide with an amino acid chain of at least six consecutive amino acids within the pre-S gene coded region of the envelope of hepatitis B virus. The vaccine being free of an amino acid sequence corresponding to the naturally occurring envelope proteins of hepatitis B virus and a physiologically acceptable diluent. The peptide being free or linked to a carrier. The carrier being a conventional carrier or a novel carrier including a lipid vesicle stabilized by cross-linking and having covalently bonded active sites on the outer surface thereon. Such novel carrier being useful not only to link the novel peptide containing an amino acid chain with amino acids within the pre-S gene coded region of the surface antigen of hepatitis B virus, but can also be used to bind synthetic peptide analogues of other viral proteins, as well as bacterial, allergen and parasitic proteins of man and animals.Type: GrantFiled: February 5, 1985Date of Patent: July 11, 1989Assignees: New York Blood Center, Inc., California Institute of TechnologyInventors: Alexander R. Neurath, Stephen B. H. Kent
-
Patent number: 4820805Abstract: A mammalian blood protein-containing composition such as whole blood, plasma, serum, plasma concentrate, cryoprecipitate, cryosupernatant, plasma fractionation precipitate or plasma fractionation supernatant substantially free of hepatitis and other lipid coated viruses with the yield of protein activity to total protein being at least 80% is disclosed. The protein-containing composition is contacted with di- or trialkylphosphate, preferably a mixture of trialkylphosphate and detergent, usually followed by removal of the di- or trialkylphosphate.Type: GrantFiled: April 22, 1985Date of Patent: April 11, 1989Assignee: New York Blood Center, Inc.Inventors: Alexander R. Neurath, Bernard Horowitz
-
Patent number: 4803156Abstract: A reagent for an ELISA determination of an antibody, the reagent comprising a peptide covalently linked to beta-lactamase. The reagent can be used in the following method to detect antibodies in a sample which involvesa. contacting the sample with protein A linked to a solid support,b. incubating the sample-protein A linked to the solid support,c. washing the incubated sample-protein A linked to the solid support,d. contacting the washed sample-protein A with the reagent,e. incubating the sample-protein A and reagent,f. washing the incubated sample-protein A-reagent, andg. determining the enzymatic activity of the resultant mass.Type: GrantFiled: September 11, 1985Date of Patent: February 7, 1989Assignees: New York Blood Center, California Institute of TechnologyInventors: Alexander R. Neurath, Stephen B. H. Kent, Nathan Strick
-
Patent number: 4764369Abstract: A mammalian blood protein-containing composition such as whole blood, plasma, serum, plasma concentrate, cryoprecipitate, cryosupernatant, plasma fractionation precipitate or plasma fractionation supernatant substantially free of hepatitis and other lipid coated viruses with the yield of protein activity to total protein being at least 80% is disclosed. The protein-containing composition is contacted with di- or trialkylphosphate, preferably a mixture of trialkylphosphate and detergent, usually followed by removal of the di- or trialkylphosphate.Type: GrantFiled: July 17, 1984Date of Patent: August 16, 1988Assignee: New York Blood Center Inc.Inventors: Alexander R. Neurath, Bernard Horowitz
-
Patent number: 4540573Abstract: A mammalian blood protein-containing composition such as whole blood, plasma, serum, plasma concentrate, cryoprecipitate, cryosupernatant, plasma fractionation precipitate or plasma fractionation supernatant substantially free of hepatitis and other lipid coated viruses with the yield of protein activity to total protein being at least 80% is disclosed. The protein-containing composition is contacted with di- or trialkylphosphate, preferably a mixture of trialkylphosphate and detergent, usually followed by removal of the di- or trialkylphosphate.Type: GrantFiled: July 14, 1983Date of Patent: September 10, 1985Assignee: New York Blood Center, Inc.Inventors: Alexander R. Neurath, Bernard Horowitz
-
Patent number: 3962421Abstract: Virus-containing media are treated and the viruses broken down into sub-units by mixing with trialkyl phosphates in the presence of a wetting agent. In comparison with conventional means, sub-unit vaccines prepared therefrom have low toxic pyrogen content, and influenza viruses of Types A and B are disrupted without substantial decreases in neuraminidase level. The method can be used on viruses contained in relatively dilute allantoic fluids as well as those in concentrated centrifugates.Type: GrantFiled: September 19, 1974Date of Patent: June 8, 1976Assignee: American Home Products CorporationInventor: Alexander R. Neurath