Abstract: According to one or more of the embodiments herein, systems and techniques for multi-system-based detection and mitigation of Global Navigation Satellite System (GNSS) spoofing are provided. In one embodiment, a method comprises: obtaining a first location of an object from a primary location determination hardware system; obtaining a second location of the object from a secondary location determination hardware system; determining a distance difference between the first location and the second location; determining whether the distance difference between the first location and the second location is acceptable based on a threshold distance; and initiating one or more mitigation actions in response to the distance difference between the first location and the second location being unacceptable.

Abstract: The present disclosure provides methods and systems for the massively-parallel detection of pathogens, such as SARS-CoV-2 virus, in a set of multiple samples via PCR test. Various implementations may provide for barcode/primer sequences that are designed to allow for a large number of samples and/or multiple pathogens to be analyzed in a single test. Included within the scope hereof are methods and systems for performing tests of multiple samples at once, via a one-pot test protocol, as well as methods and systems for designing test parameters (such as barcode/primer sequences) in a manner that allows for parallel testing.

Abstract: The invention provides CRISPR-based compositions and methods comprising non-repetitive sgRNA promoter and handle sequences for simultaneous, stable expression of multiple sgRNAs.

Abstract: The current invention is a Photorefractive Flash Device and System. It is a device that can be clipped to any portable computing device to illuminate the pupil in a way, that allows a proper pupillary reflex. On the backside of the device is a photoreceptor, on the frontside—facing the persons eyes are LEDs, centered around an opening where the lens of the camera looks through. A smartphone-app triggers the flashlight of the camera. The photoreceptor of the device senses this flash and triggers the six LEDs to flash sequentially within 200 milliseconds. 200 milliseconds is the time, the pupil needs to react. By staying under this 200 milliseconds, it can achieve high-quality pictures of the pupillary reflection, before the pupil contracts.

Abstract: The current invention involves the use of portable devices such as a smart phone or tablet to perform an examination and diagnostic of an eye or pair of eyes using a photorefraction system and technique. The portable device would send a ray of light through the cornea and take measurements of the refraction. It would then use this information to diagnose any defects of the eye using a software application (app) or program or it can transmit the information to a server on which the diagnostic software is located where the server will run the diagnostic analysis.