Patents by Inventor Alexander Reth

Alexander Reth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220259642
    Abstract: The invention pertains to a method for determining the risk of an Avian Pathogenic E. coli (APEC) infection in an avian flock, the method comprising determining the quantitative ratios of the amount of specific virulence factors (VF), each with respect to the amount of E. coli reference gene is ybbW (SEQ ID NO: 6) or functional fragments thereof, in a pooled sample deriving from the avian flock, wherein the specific virulence factors include at least the genes iroN (SEQ ID NO.: 1) and ompT (SEQ ID NO: 2) or functional fragments thereof.
    Type: Application
    Filed: July 6, 2020
    Publication date: August 18, 2022
    Inventors: Michelle DARGATZ, Frank THIEMANN, Michaela WEISSMANN, Stefan PELZER, Monika FLÜGEL, Florian BÖHL, Andreas KAPPEL, Emeka Ignatius IGWE, Alexander RETH
  • Publication number: 20160265072
    Abstract: The invention relates to a microorganism that produces and/or secretes an organic chemical compound, wherein the microorganism has an increased expression, compared to the respective starting strain, of a polypeptide LpdA with the activity of a transhydrogenase; and a process for producing an organic chemical compound using the microorganism according to the invention.
    Type: Application
    Filed: January 13, 2014
    Publication date: September 15, 2016
    Inventors: Frederik Walter, Marcus Persicke, Jorn Kalinowski, Andrea Huser, Wilfried Claes, Alexander Reth
  • Publication number: 20160244490
    Abstract: The invention relates to a microorganism which produces and/or secretes an organic-chemical compound, wherein the microorganism has increased expression, compared to the particular starting strain, of one or more protein subunits of the ABC transporter having the activity of a trehalose importer, said microorganism being capable of taking up trehalose from the medium; and to a method for the production of an organic-chemical compound, using the microorganism according to the invention, wherein accumulation of trehalose in the fermentation broth is reduced or avoided.
    Type: Application
    Filed: May 5, 2016
    Publication date: August 25, 2016
    Applicant: Evonik Degussa GmbH
    Inventors: Stephan Hans, Brigitte Bathe, Alexander Reth, Wilfried Claes, Reinhard Krämer, Gerd Seibold, Alexander Henrich
  • Patent number: 9422568
    Abstract: A process for preparing L-amino acids employing coryneform bacteria in which the AmtR regulator has been attenuated is provided. Recombinant bacteria, polynucleotides and vectors corresponding to or having the attenuated AmtR regulator are disclosed.
    Type: Grant
    Filed: October 22, 2013
    Date of Patent: August 23, 2016
    Assignee: EVONIK DEGUSSA GmbH
    Inventors: Nadja Jessberger, Andreas Burkovski, Brigitte Bathe, Alexander Reth
  • Patent number: 9359413
    Abstract: The invention relates to a microorganism which produces and/or secretes an organic-chemical compound, wherein the microorganism has increased expression, compared to the particular starting strain, of one or more protein subunits of the ABC transporter having the activity of a trehalose importer, said microorganism being capable of taking up trehalose from the medium; and to a method for the production of an organic-chemical compound, using the microorganism according to the invention, wherein accumulation of trehalose in the fermentation broth is reduced or avoided.
    Type: Grant
    Filed: April 3, 2012
    Date of Patent: June 7, 2016
    Assignee: Evonik Degussa GmbH
    Inventors: Stephan Hans, Brigitte Bathe, Alexander Reth, Wilfried Claes, Reinhard Krämer, Gerd Seibold, Alexander Henrich
  • Publication number: 20160053335
    Abstract: The invention relates to a microorganism that produces and/or secretes an organic chemical compound, wherein the microorganism has an increased expression, compared to the respective starting strain, of a polypeptide LpdA with the activity of a transhydrogenase; and a process for producing an organic chemical compound using the microorganism according to the invention.
    Type: Application
    Filed: January 13, 2014
    Publication date: February 25, 2016
    Inventors: Frederik Walter, Marcus Persicke, Jörn Kalinowski, Andrea Hüser, Wilfried Claes, Alexander Reth
  • Patent number: 9074229
    Abstract: The invention relates to an isolated polynucleotide having promoter activity, a variant of the promoter of the gap gene coding for glyceraldehyde-3-phosphate dehydrogenase; and to a microorganism which produces and/or secretes a fine chemical, the microorganism including the isolated polynucleotide having promoter activity, which enables various genes to be overexpressed in comparison with the particular starting strain; and to a process for preparing fine chemicals using the microorganism.
    Type: Grant
    Filed: January 28, 2015
    Date of Patent: July 7, 2015
    Assignee: EVONIK DEGUSSA GmbH
    Inventors: Alexander Reth, Brigitte Bathe, Stephan Hans, Wilfried Claes
  • Patent number: 9045762
    Abstract: The invention relates to an isolated polynucleotide having promoter activity, a variant of the promoter of the gap gene coding for glyceraldehyde-3-phosphate dehydrogenase; and to a microorganism which produces and/or secretes a fine chemical, the microorganism including the isolated polynucleotide having promoter activity, which enables various genes to be overexpressed in comparison with the particular starting strain; and to a process for preparing fine chemicals using the microorganism.
    Type: Grant
    Filed: November 4, 2014
    Date of Patent: June 2, 2015
    Assignee: EVONIK DEGUSSA GmbH
    Inventors: Alexander Reth, Brigitte Bathe, Stephan Hans, Wilfried Claes
  • Publication number: 20150140614
    Abstract: The invention relates to an isolated polynucleotide having promoter activity, a variant of the promoter of the gap gene coding for glyceraldehyde-3-phosphate dehydrogenase; and to a microorganism which produces and/or secretes a fine chemical, the microorganism including the isolated polynucleotide having promoter activity, which enables various genes to be overexpressed in comparison with the particular starting strain; and to a process for preparing fine chemicals using the microorganism.
    Type: Application
    Filed: January 28, 2015
    Publication date: May 21, 2015
    Applicant: EVONIK DEGUSSA GMBH
    Inventors: ALEXANDER RETH, BRIGITTE BATHE, STEPHAN HANS, WILFRIED CLAES
  • Publication number: 20150056666
    Abstract: The invention relates to an isolated polynucleotide having promoter activity, a variant of the promoter of the gap gene coding for glyceraldehyde-3-phosphate dehydrogenase; and to a microorganism which produces and/or secretes a fine chemical, the microorganism including the isolated polynucleotide having promoter activity, which enables various genes to be overexpressed in comparison with the particular starting strain; and to a process for preparing fine chemicals using the microorganism.
    Type: Application
    Filed: November 4, 2014
    Publication date: February 26, 2015
    Applicant: Evonik Degussa GmbH
    Inventors: Alexander RETH, Brigitte Bathe, Stephan Hans, Wilfried Claes
  • Patent number: 8912313
    Abstract: The invention relates to an isolated polynucleotide having promoter activity, a variant of the promoter of the gap gene coding for glyceraldehyde-3-phosphate dehydrogenase; and to a microorganism which produces and/or secretes a fine chemical, the microorganism including the isolated polynucleotide having promoter activity, which enables various genes to be overexpressed in comparison with the particular starting strain; and to a process for preparing fine chemicals using the microorganism.
    Type: Grant
    Filed: June 27, 2012
    Date of Patent: December 16, 2014
    Assignee: Evonik Degussa GmbH
    Inventors: Alexander Reth, Brigitte Bathe, Stephan Hans, Wilfried Claes
  • Publication number: 20140127787
    Abstract: A process for preparing L-amino acids employing coryneform bacteria in which the AmtR regulator has been attenuated is provided. Recombinant bacteria, polynucleotides and vectors corresponding to or having the attenuated AmtR regulator are disclosed.
    Type: Application
    Filed: October 22, 2013
    Publication date: May 8, 2014
    Applicant: EVONIK DEGUSSA GmbH
    Inventors: Nadja JESSBERGER, Andreas Burkovski, Brigitte Bathe, Alexander Reth
  • Patent number: 8697850
    Abstract: A process for preparing L-amino acids employing coryneform bacteria in which the AmtR regulator has been attenuated is provided. Recombinant bacteria, polynucleotides and vectors corresponding to or having the attenuated AmtR regulator are disclosed.
    Type: Grant
    Filed: May 19, 2009
    Date of Patent: April 15, 2014
    Assignee: Evonik Degussa GmbH
    Inventors: Nadja Jessberger, Andreas Burkovski, Brigitte Bathe, Alexander Reth
  • Publication number: 20130004999
    Abstract: The invention relates to an isolated polynucleotide having promoter activity, a variant of the promoter of the gap gene coding for glyceraldehyde-3-phosphate dehydrogenase; and to a microorganism which produces and/or secretes a fine chemical, the microorganism including the isolated polynucleotide having promoter activity, which enables various genes to be overexpressed in comparison with the particular starting strain; and to a process for preparing fine chemicals using the microorganism.
    Type: Application
    Filed: June 27, 2012
    Publication date: January 3, 2013
    Applicant: Evonik Degussa GmbH
    Inventors: Alexander RETH, Brigitte Bathe, Stephan Hans, Wilfried Claes
  • Publication number: 20120252075
    Abstract: The invention relates to a microorganism which produces and/or secretes an organic-chemical compound, wherein the microorganism has increased expression, compared to the particular starting strain, of one or more protein subunits of the ABC transporter having the activity of a trehalose importer, said microorganism being capable of taking up trehalose from the medium; and to a method for the production of an organic-chemical compound, using the microorganism according to the invention, wherein accumulation of trehalose in the fermentation broth is reduced or avoided.
    Type: Application
    Filed: April 3, 2012
    Publication date: October 4, 2012
    Applicant: Evonik Degussa GmbH
    Inventors: Stephan Hans, Brigitte Bathe, Alexander Reth, Wilfried Claes, Reinhard Krämer, Gerd Seibold, Alexander Henrich
  • Publication number: 20090311758
    Abstract: A process for preparing L-amino acids employing coryneform bacteria in which the AmtR regulator has been attenuated is provided. Recombinant bacteria, polynucleotides and vectors corresponding to or having the attenuated AmtR regulator are disclosed.
    Type: Application
    Filed: May 19, 2009
    Publication date: December 17, 2009
    Applicant: EVONIK DEGUSSA GmbH
    Inventors: Nadja Jessberger, Andreas Burkovski, Brigitte Bathe, Alexander Reth
  • Publication number: 20030175911
    Abstract: The invention relates to a process for the preparation of L-amino acids by the fermentation of coryneform bacteria. The process involves: fermenting an L-amino acid-producing bacteria in which at least the zwf gene is amplified; concentrating the L-amino acid in the medium or in the cells of the bacteria; and isolating the L-amino acid produced.
    Type: Application
    Filed: January 3, 2003
    Publication date: September 18, 2003
    Inventors: Stephen Hans, Brigitte Bathe, Alexander Reth, Georg Thierbach, Caroline Kreutzer, Bettina Mockel