Abstract: This document provides integrated systems for controlling fluid flow in a fluidic device. Methods of using such systems are also described herein.

Abstract: This document provides methods, devices, and systems for detecting the presence, absence, or amount of two or more analytes present within a small volume (e.g., less than 10 ?L) of a sample (e.g., a blood sample) obtained from a mammal (e.g., a human such as a human neonate). For example, methods and materials for using plasma separation and multiplex analyte detection to detect two or more analytes (e.g., proteins, carbohydrates, lipids, nucleic acids, intact cells, intact viruses, intact microorganisms, and/or chemicals) within a small volume of a blood sample are provided.

Abstract: This document relates to materials, such as microcapsules, and methods for detecting and/or quantifying analytes in a sample such as a biological sample. Microcapsules can comprise a hydrogel shell and an aqueous core comprising one or more analyte capture beads. The aqueous core can further comprise one or more analyte detection beads.

Abstract: The present invention provides a sensor for detection of disease markers, and methods for detecting a disease marker, using a conductive hydrogel modified with a biorecognition element.

Abstract: A cell-containing, three-dimensional hydrogel microstructure that closely imitate a native cell environment. The three-dimensional hydrogel microstructures may be formed using photolithography either alone or in conjunction with the use of microfluidic networks. The resulting cell-containing, three-dimensional hydrogel microstructures can be used efficiently in various cell monitoring applications, including drug candidate screening systems.