Abstract: The invention is directed to a method for activating CAR cells having at least one chimeric antigen binding receptor in a sample by incubating the sample with at least one substrate provided on its surface with at least one anti-CAR idiotype antibody and/or at least one antigen selected from the group consisting of CD19, CD20, CD22, BCMA, CD33, MSLN, CD123, HER2, GD2, EGFR, PSMA, MUC1, CD318, TSPAN8, CD66c, CEA, CLA, CD276, FolR1, CLEC12A, CLL-1 and CD371, and with at least one costimulatory molecule selected from the group consisting of CD28, CD2, CD6, CD26, CD53 and LFA-1 characterized in that the sample is incubated with the at least substrate in suspension thereby activating the CAR T cells to express markers selected from the group consisting of mRNA, effector molecules or cell surface activation markers.

Abstract: The present invention generally relates to antibodies that bind to CD3 and CD19, e.g. for activating T cells. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the antibodies, and to methods of using them in the treatment of disease.

Abstract: A rotor of a gas turbine having two adjacent rotor discs, on each of which moving blades are fastened, an annular rotor component being arranged between the rotor discs and having at its opposite ends circumferential annular grooves, in each of which a circumferential fastening projection on the respective rotor disc engages. When the rotor is stationary a first outer flank of the first annular groove rests under pressure against a first outer flank of the first fastening projection and there is play between a first inner flank of the first annular groove and a first inner flank of the first fastening projection.

Abstract: Brushware contains the constituents of monofilaments or bristles, and at least one head, handle, and/or neck. The constituents contain or are made of polymers from the same polymer class selected from among polymers and/or copolymers, and wherein the polymer class is selected from polyamides or polyesters.

Abstract: An improved process can be used for the acid hydrolysis of polylaurolactam with sulfuric acid. An especially suitable starting material is polylaurolactam which is intended for recycling and which is characterized by a low laurolactam content.

Abstract: A mixture contains at least one polyether block amide (PEBA) and at least one poly(meth)acrylate, selected from poly(meth)acrylimides, poly-alkyl(meth)acrylates, and mixtures thereof. The mass ratio of PEBA to poly(meth)acrylate is 95:5 to 60:40. The polyalkyl(meth)acrylate contains 80% by weight to 99% by weight of methyl methacrylate (MMA) units and 1% by weight to 20% by weight of C1-C10-alkyl acrylate units, based on the total weight of polyalkyl(meth)acrylate. The mixture can be processed to give foamed mouldings. The mouldings can he used in footwear soles, stud material, insulation or insulating material, damping components, lightweight components, or in a sandwich structure.

Abstract: An end-to-end data curation system and the various methods used in linking, matching, and cleaning large-scale data sources. The goal of this system is to provide scalable and efficient record deduplication. The system uses a crowd of experts to train the system. The system operator can optionally provide a set of hints to reduce the number of questions send to the experts. The system solves the problem of schema mapping and record deduplication a holistic way by unifying these problems into a unified linkage problem.

Abstract: The present invention relates to an additive method for the production of solid or semi-solid two- or three-dimensional objects containing one of more pharmaceutical active agent(s), as well as to the objects produced by said method, such as semi-solid or solid dosage forms or medical devices. The method is a three-dimensional printing method in which individual defined volume increments are printed, which can be selected essentially freely as regards contained active agents, used carrier materials, shape, size, color, concentrations of active agents, and arrangement in the produced object.

Abstract: A computer-implemented methods is for training a machine learning algorithm to detect anomalies in processes. A computer-implemented method is for detecting anomalies in processes. Further, data processing systems and a system are for detecting anomalies in processes. A training dataset of a process is provided including a first number of training usage sequences. A second number of process trees is created based upon the usage sequences by way of a process mining algorithm. The creation of the process trees is subject to a certain randomness.

Abstract: A molding compound contains polyether block amide (PEBA) based on a subunit 1 made of at least one linear aliphatic diamine having 5 to 15 C atoms and at least one linear aliphatic or aromatic dicarboxylic acid having 6 to 16 C atoms. The PEBA also contains a subunit 2 made of at least one polyether diol having at least 3 C atoms per ether oxygen and primary OH groups at the chain ends. The sum of the C atoms of diamine and dicarboxylic acid is odd and is 19 or 21, and the number-average molar mass of the subunit 2 is 200 to 900 g/mol. A molded object can be created from the molding compound, which can be a molded part, a film, a bristle, a fiber, or a foam.

Abstract: A device providing concurrent audio streaming to multiple wireless audio output devices may include at least one processor configured to receive a user selection of at least two paired audio output devices. The at least one processor may be further configured to connect to each of the at least two of the paired audio output devices. The at least one processor may be further configured to synchronize at least one audio output synchronization parameter across each of the at least two of the paired audio output devices. The at least one processor may be further configured to concurrently stream a respective audio stream to each of the at least two of the paired audio output devices.

Abstract: A mixture contains at least one amino-regulated polyether block amide (PEBA) and at least one poly(meth)acrylate selected from poly(meth)acrylimides, polyalkyl(meth)acrylates, and mixtures thereof. The mass ratio of PEBA to poly(meth)acrylate is 95:5 to 60:40. The polyalkyl(meth)acrylate contains 80% by weight to 99% by weight of methyl methacrylate (MMA) units and 1% by weight to 20% by weight of C1-C10-alkyl acrylate units, based on the total weight of polyalkyl(meth)acrylate. The mixture can be processed to give foamed mouldings. The mouldings can be used in footwear soles, stud material, insulation or insulating material, damping components, lightweight components, or in a sandwich structure.

Abstract: A data curation system is provided that includes various methods to enable efficient reuse of human and machine effort. To reuse effort, various facilities are presented that model, save, and allow for querying of provenance and state information of a curation workflow and allow for incremental, stateful transitions of the data and metadata thereof.

Abstract: An end-to-end data curation system and the various methods used in linking, matching, and cleaning large-scale data sources. The goal of this system is to provide scalable and efficient record deduplication. The system uses a crowd of experts to train the system. The system operator can optionally provide a set of hints to reduce the number of questions send to the experts. The system solves the problem of schema mapping and record deduplication a holistic way by unifying these problems into a unified linkage problem.

Abstract: An end-to-end data curation system and the various methods used in linking, matching, and cleaning large-scale data sources. The goal of this system is to provide scalable and efficient record deduplication. The system uses a crowd of experts to train the system. The system operator can optionally provide a set of hints to reduce the number of questions sent to the experts. The system solves the problem of schema mapping and record deduplication in a holistic way by unifying these problems into a unified linkage problem.

Abstract: A device providing concurrent audio streaming to multiple wireless audio output devices may include at least one processor configured to receive a user selection of at least two paired audio output devices. The at least one processor may be further configured to connect to each of the at least two of the paired audio output devices. The at least one processor may be further configured to synchronize at least one audio output synchronization parameter across each of the at least two of the paired audio output devices. The at least one processor may be further configured to concurrently stream a respective audio stream to each of the at least two of the paired audio output devices.

Abstract: A data curation system is provided that includes various methods to enable efficient reuse of human and machine effort. To reuse effort, various facilities are presented that model, save, and allow for querying of provenance and state information of a curation workflow and allow for incremental, stateful transitions of the data and metadata thereof.

Abstract: A data curation system that includes various methods to enable efficient reuse of human and machine effort. To reuse effort, various facilities are presented that model, save, and allow the querying of provenance and state information of a curation workflow and allow for incremental, stateful transitions of the data and the metadata.

Abstract: An end-to-end data curation system and the various methods used in linking, matching, and cleaning large-scale data sources. The goal of this system is to provide scalable and efficient record deduplication. The system uses a crowd of experts to train the system. The system operator can optionally provide a set of hints to reduce the number of questions sent to the experts. The system solves the problem of schema mapping and record deduplication in a holistic way by unifying these problems into a unified linkage problem.

Abstract: An end-to-end data curation system and the various methods used in linking, matching, and cleaning large-scale data sources. The goal of this system is to provide scalable and efficient record deduplication. The system uses a crowd of experts to train the system. The system operator can optionally provide a set of hints to reduce the number of questions send to the experts. The system solves the problem of schema mapping and record deduplication a holistic way by unifying these problems into a unified linkage problem.