Abstract: In a gasket ring for sealing flange connections and flange connections including the gasket ring, preferably connections of flanges made of plastic, in the radial direction the gasket ring is subdivided into a primary gasket ring and a secondary gasket ring, both rings being concentrically arranged and connected to each other, the secondary gasket ring being arranged on the radial outside of the primary gasket ring, the modulus of elasticity of material of the secondary gasket ring being at least 10 times higher than the modulus of elasticity of the material of the primary gasket ring, the secondary gasket ring in the major part of its radial extension having an axial main height smaller than the maximum axial height of the primary gasket ring.

Abstract: The invention relates to methods for the treatment of cancer. In particular, the invention relates to methods for the treatment of cancer, comprising administration of a high dose of an antibody capable of binding a human V?9V?2 T cell receptor.

Abstract: In a gasket ring for sealing flange connections and flange connections including the gasket ring, preferably connections of flanges made of plastic, in the radial direction the gasket ring is subdivided into a primary gasket ring and a secondary gasket ring, both rings being concentrically arranged and connected to each other, the secondary gasket ring being arranged on the radial outside of the primary gasket ring, the modulus of elasticity of material of the secondary gasket ring being at least 10 times higher than the modulus of elasticity of the material of the primary gasket ring, the secondary gasket ring in the major part of its radial extension having an axial main height smaller than the maximum axial height of the primary gasket ring.

Abstract: The invention relates to a method for producing a sealing element, in particular a sealing ring, for sealing a connection of two flanges, of which at least one has a non-plane sealing surface, wherein at a plurality of circumferential positions (UP1 to UPn) lying in the circumferential direction of at least one flange, preferably of both flanges, in particular circumferential positions that are equidistant from each other, a distance value between the sealing surfaces of the flanges facing each other is determined at several locations that lie one behind the other in a direction perpendicular to the circumferential tangent, in particular in a radial direction, for each of the circumferential positions and a single thickness value is determined from the several distance values of each circumferential position and a sealing element is produced in dependence on all thickness values, which depend on the circumferential position, which sealing element has a thickness that depends on the circumferential position, w

Abstract: The invention relates to a method for producing a sealing element, in particular a sealing ring, for sealing a connection of two flanges, of which at least one has a non-plane sealing surface, wherein at a plurality of circumferential positions (UP1 to UPn) lying in the circumferential direction of at least one flange, preferably of both flanges, in particular circumferential positions that are equidistant from each other, a distance value between the sealing surfaces of the flanges facing each other is determined at several locations that lie one behind the other in a direction perpendicular to the circumferential tangent, in particular in a radial direction, for each of the circumferential positions and a single thickness value is determined from the several distance values of each circumferential position and a sealing element is produced in dependence on all thickness values, which depend on the circumferential position, which sealing element has a thickness that depends on the circumferential position, w

Abstract: A multilayer, unitary gasket including at least one inner layer of expanded PTFE disposed between a first substantially air impermeable outer layer and a second substantially air impermeable outer layer, and a substantially air impermeable region bridging the first and second substantially air impermeable layers. The inventive gasket forms a substantially air impermeable seal when compressed at low stress.