Abstract: An Integrated Virtual Patient Framework (IVPF) for providing decision support that evolves with increasing data collected on a given patient. Support decisions for patients with limited data is made using statistical prediction tools derived from historical trajectories of similar patients. As patient histories grow, decision support is provided by mathematical models that constrain the possible dynamics of the patient to more detailed predictive models. Weights for each model are assigned depending on uncertainties arising from data fitting and model properties. As new data are entered into a patient record, the models are recalibrated and the weights are adjusted, leading to updated decision support information. The framework also suggests the benefit of additional follow-up data collection events, optimizing the data collection as well as how the IVPF generates predictions. The framework also may present scenarios to patients in a way that informs them of treatment outcomes, given various strategies.

Abstract: The present disclosure provides methods and systems for nucleic acid sequencing. Such systems and methods may use a single flow cell to perform unbiased and/or biased sequencing to generate libraries of nucleic acid molecules. An aspect of the present disclosure provides a method for increasing complexity of a sample for sequencing, the method comprising: providing a first nucleic acid sample having a first degree of complexity that differs from a desired degree of complexity; providing a second nucleic acid sample having a second degree of complexity that differs from the first degree of complexity and that differs from the desired degree of complexity; pooling at least a portion of the first nucleic acid sample and at least a portion of the second nucleic acid sample, thereby generating a pooled nucleic acid sample having the desired degree of complexity; and sequencing at least a portion of the pooled nucleic acid sample.

Abstract: The present disclosure is directed to a filtering assembly and a method of manufacturing a filtering assembly. The filtering assembly may increases an effective screening area. Specifically, embodiments disclosed herein include a screen housing having two sidewalls and two end walls, defining a perimeter with a length and a width. The screen housing also includes a top face and a bottom face. A plurality of screen segments may be positioned on the top face of the screen housing, such that the plurality of screen segments on the top face provide a screening surface area less than a total surface area of the top face.

Abstract: Components, systems, and methods for gas sensing identification are generally disclosed. In some embodiments, a characteristic of an article (e.g., identity, authenticity, property, product associated information such as age or quality, etc.) may be determined by determining the presence (e.g., an amount) or absence of a chemical compound (or compounds) emanating from the article. For example, the presence or absence of the compound (or compounds) emanating from the article identifies a characteristic of the article. In some embodiments, the chemical compound(s) has been proactively added to the article. That is to say, in some embodiments, the chemical compound is not inherently associated with the article but is added in order to, for example, identify a characteristic of the article.

Abstract: A pulse generator comprises a header connector assembly coupled with a housing. The header connector assembly includes a connector assembly and a header enclosing the connector assembly. The connector assembly includes an electrically insulative segment, a first electrically conductive segment, and a second electrically conductive segment axially spaced apart from the first electrically conductive segment by the electrically insulative segment. Each electrically conductive segment includes a connector ring, a spring housing and a spring supported by the spring housing. The connector ring and spring housing are in electrical communication with each other. The electrically insulative segment includes an insulator ring that is positioned between the first and second electrically conductive segments. The insulator ring includes a first end and a second end axially opposite the first end.

Abstract: Disclosed herein is an implantable electronic device including a housing containing an electrical circuit. The implantable electronic device further includes an antenna assembly coupled to the electrical circuit. The antenna assembly includes an antenna including a dielectric antenna body within which an antenna trace is disposed. Portions of the antenna trace are disposed in offset transverse layers in a non-overlapping arrangement, thereby reducing capacitive coupling between the layers of the antenna trace. In certain implementations, the antenna assembly includes one or more capacitive features that selectively overlap portions of the antenna trace and facilitate tuning of the antenna.

Abstract: Disclosed herein is an implantable electronic device having a housing containing an electrical circuit. The implantable electronic device further includes an antenna assembly coupled to the electrical circuit. The antenna assembly has an antenna with a dielectric antenna body within which an antenna trace is disposed. Portions of the antenna trace are disposed in offset transverse layers in a non-overlapping arrangement, thereby reducing capacitive coupling between the layers of the antenna trace. In certain implementations, the antenna assembly has one or more capacitive features that selectively overlap portions of the antenna trace and facilitate tuning of the antenna.

Abstract: An optical communication system, device, and method are disclosed. An illustrative optical communication system is disclosed to include a carrier Integrated Circuit (IC) chip having an amplifier circuit, a bias plane, and a ground plane. The amplifier circuit, bias plane, and the ground plane may each operate at or above a nominal voltage of zero volts. A laser diode may be integrated with an electro-absorption modulator into a single IC chip, where the laser diode is mounted on the carrier IC chip and is electrically connected with the amplifier circuit of the carrier IC chip through a bond wire.

Abstract: The present disclosure is directed to a filtering assembly and a method of manufacturing a filtering assembly. The filtering assembly may increases an effective screening area. Specifically, embodiments disclosed herein include a screen housing having two sidewalls and two end walls, defining a perimeter with a length and a width. The screen housing also includes a top face and a bottom face. A plurality of screen segments may be positioned on the top face of the screen housing, such that the plurality of screen segments on the top face provide a screening surface area less than a total surface area of the top face.

Abstract: A tension lever includes an outer body including a top, a bottom, and a plurality of outer body sides including a first outer body side and a second outer body side opposite to and facing the first outer body side, the first outer body side having a substantially planar surface extending along a first direction and a second direction crossing the first direction, an upper first opening defined in the top and defining an upper inner body that extends along the second direction, a lower first opening defined in the bottom and defining a lower inner body that extends along the second direction, a second opening defined in the first outer body side and the second outer body side, the second opening defining a channel that extends along a third direction crossing the second direction, and a barbell including a shaft and a pair of beads at opposing ends of the shaft, the barbell being received in the second opening.

Abstract: A filtering assembly includes a screen housing having two sidewalls and two end walls, defining a perimeter with a length and a width. The screen housing also includes a top face and a bottom face. A plurality of screen segments are positioned on the top face of the screen housing, such that the plurality of screen segments on the top face provide a screening surface area less than a total surface area of the top face, and a plurality of screen segments are positioned on the bottom face of the screen housing, such that the plurality of screen segments on the bottom face provide a screening surface area less than a total surface area of the bottom face. A total screening surface area of the filtering assembly is greater than the total surface area of the top face.

Abstract: A vibratory separator includes a screen frame having an upper screen surface and a plurality of openings and a first screen insert disposed in a first opening of the plurality of openings of the screen frame, the screen insert having a screen surface positioned at a first height above the supper screen surface. The vibratory separator also includes a second screen insert disposed in a second opening of the plurality of openings of the second screen frame, wherein a screen surface of the second screen insert is positioned at a second height. The second height may be different from the first height. A method of processing fluid includes providing a flow of fluid to a vibratory separator, and flowing the fluid over a screen having a first screen insert positioned at a first height.

Abstract: A controlled release composition containing a water-active material in the form of granules having a protective barrier coating capable of releasing the water-active material under predetermined release conditions, wherein the protective barrier coating comprises a polymer blend of two latex polymers, a method of preparing such a composition, a sprayable solution useful in the preparation of the composition, and the use of the composition for breaking a fracturing fluid.

Abstract: Disclosed herein is an implantable electronic device having a housing containing an electrical circuit. The implantable electronic device further includes an antenna assembly coupled to the electrical circuit. The antenna assembly has an antenna with a dielectric antenna body within which an antenna trace is disposed. Portions of the antenna trace are disposed in offset transverse layers in a non-overlapping arrangement, thereby reducing capacitive coupling between the layers of the antenna trace. In certain implementations, the antenna assembly has one or more capacitive features that selectively overlap portions of the antenna trace and facilitate tuning of the antenna.

Abstract: A pulse generator comprises a header connector assembly coupled with a housing. The header connector assembly includes a connector assembly and a header enclosing the connector assembly. The connector assembly includes an electrically insulative segment, a first electrically conductive segment, and a second electrically conductive segment axially spaced apart from the first electrically conductive segment by the electrically insulative segment. Each electrically conductive segment includes a connector ring, a spring housing and a spring supported by the spring housing. The connector ring and spring housing are in electrical communication with each other. The electrically insulative segment includes an insulator ring that is positioned between the first and second electrically conductive segments. The insulator ring includes a first end and a second end axially opposite the first end.

Abstract: A sensor material includes a plurality of conductive carbonaceous nanomaterial particles, a detector selected to selectively interact with an analyte of interest; and an ionic liquid wherein the plurality of conductive carbonaceous nanomaterial particles, the detector and the ionic liquid are combined to form a paste. Further, the analyte can diffuse into the paste to interact with the detector to change the conductivity of the paste. Device based on said sensor material and methods or using said devices are also described.

Abstract: A controlled release composition containing a water-active material in the form of granules having a protective barrier coating capable of releasing the water-active material under predetermined release conditions, wherein the protective barrier coating comprises a polymer blend of two latex polymers, a method of preparing such a composition, a sprayable solution useful in the preparation of the composition, and the use of the composition for breaking a fracturing fluid.

Abstract: An Integrated Virtual Patient Framework (IVPF) that incorporates dynamic and mechanistic modeling to provide for testing of finer patient-specific data subdivisions, and also allows non-standard therapies to be queried for success. New measurements of patient follow-up data can be rapidly incorporated into the IVPF in order to dynamically update the optimization of the treatment strategy, making the IVPF a powerful tool for implementing adaptive therapies. The IVPF is built using software is accessible to the nonmathematician. Inputs, options, and decision recommendations are delivered in a fashion that will have clear meaning to the clinician deciding the treatment. The system is adaptable to the different decision processes which are used in the clinic. Each disease has a particular decision set that the framework will be able to handle.

Abstract: A filtering assembly includes a screen housing having two sidewalls and two end walls, defining a perimeter with a length and a width. The screen housing also includes a top face and a bottom face. A plurality of screen segments are positioned on the top face of the screen housing, such that the plurality of screen segments on the top face provide a screening surface area less than a total surface area of the top face, and a plurality of screen segments are positioned on the bottom face of the screen housing, such that the plurality of screen segments on the bottom face provide a screening surface area less than a total surface area of the bottom face. A total screening surface area of the filtering assembly is greater than the total surface area of the top face.

Abstract: A method of forming a shaker screen includes forming a frame, and attaching a first sealing element to at least one side of an outer perimeter of the frame, wherein the attaching comprises aligning a first mating surface of the frame to a second mating surface of the first sealing element, and wherein the first mating surface of the frame includes an extension, and the second mating surface of the first sealing element includes a groove configured to align with the extension. A system of sealing shaker screens includes a first screen and a second screen disposed adjacent the first screen, wherein a first sealing element of a first frame and a portion of the second screen interact to provide a seal between the first screen and the second screen.