Abstract: Provided herein are DNAzymes conjugated to a penetration-enhancing moiety and methods of facilitating entry of DNAzymes into bacteria, utilizing same. Also provided are methods of targeting bacterial genes, methods of treating or inhibiting the progression of bacterial infections, and methods of increasing susceptibility of bacteria to an antibiotic, using the described conjugated DNAzymes, which are optionally capable of silencing at least one target gene of bacteria and/or rendering bacteria susceptible to antibiotic treatment.

Abstract: Methods of labeling or barcoding molecules within one or more portions of a plurality of cells are provided. Kits and systems for labeling or barcoding molecules within one or more portions of a plurality of cells are also provided. The methods, kits, and systems may utilize photo-controlled adapter sequences, nucleic acids tags, and/or linkers.

Abstract: Provided herein are modified DNAzymes, including DNAzymes with overhang sequences not complementary to the target RNA, in particular, overhangs with high G content. Also provided are compositions comprising the DNAzyme; vectors including the DNAzymes; pharmaceutical compositions including the vectors; and methods including any of the above for cleaving a target RNA; inducing cell death; and treating various diseases and disorders.

Abstract: Provided herein are compositions and methods comprising a DNAzyme targeting a transcript encoding a cell wall synthesis enzyme, for use in reducing an amount of a biofilm in a subject with a bacterial infection; increasing or enhancing antibiotic susceptibility in a subject with a bacterial infection; and inhibiting bacterial growth in a subject with a bacterial infection.

Abstract: An oligonucleotide is provided. The oligonucleotide comprising a nucleic acid sequence of at least one DNAzyme, the DNAzyme being capable of silencing at least one target gene of a bacteria to thereby render the bacteria susceptible to antibiotic treatment.

Abstract: Provided herein are DNAzymes conjugated to an organic moiety and methods of facilitating entry of DNAzymes into bacteria, utilizing same. Also provided are methods of targeting bacterial target genes, methods of treating or inhibiting the progression of bacterial infections, and methods of increasing susceptibility of bacteria to an antibiotic, using the described DNAzymes, which are optionally capable of silencing at least one target gene of bacteria and/or rendering bacteria susceptible to antibiotic treatment.

Abstract: Methods and apparatuses for operating with writeable media. In one aspect of the invention, an exemplary method includes inserting a writeable media into a drive system which is coupled to a data processing system, instructing the data processing system to write or erase first data on the writeable media, and instructing the data processing system to eject the writeable media from the drive system, wherein upon the instructing of the data processing system to eject, the data processing system writes or erases the first data on the writeable media. The present invention includes other methods and apparatuses which perform at least one of these methods, including data processing systems which perform at least one of these methods and computer readable media which when executed on data processing systems cause the systems to perform at least one of these methods.

Abstract: Disclosed are methods of detecting cardiovascular disorders using reference profiles. Also disclosed are methods of identifying agents for treating cardiovascular disorders.

Abstract: Disclosed are methods of detecting urinary tract and prostatic disorders using reference profiles. Also disclosed are methods of identifying agents for treating urinary tract and prostatic disorders.

Abstract: Operations that involve denormalized numbers are handled by restructuring the input values for an operation as normalized numbers, and performing calculations on the normalized numbers. As a first step in the process of performing an operation, a determination is made whether input values for the operation contain one or more denormalized numbers. For certain types of operations, a determination is made whether the input values are such that the output value from the operation will be a denormalized number. For each operation in which either the input values or output values comprise a denormalized number, the input values are scaled to produce values that are not denormalized. Once the appropriate factoring has been carried out, the requested operation is performed, using normalized numbers, to produce an intermediate result which is then adjusted to account for the initial scaling.

Abstract: An apparatus capable of determining the clotting time of blood, without requiring continuous inspection of the sample, is disclosed. The apparatus includes a support frame, which is capable of supporting therein a syringe containing a blood sample, and a turntable adapted to rotate at a known rate of speed. Blood from the syringe drops onto the turntable, the clotting time being automatically and graphically depicted by a chart rotatively carried upon the turntable. The apparatus can also be employed for determining variations in the viscosity of blood plasma and other fluids.