Patents by Inventor Alexander Rudensky

Alexander Rudensky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Depleting tumor-specific tregs
    Patent number: 10087259
    Abstract: The present invention provides, among other things, methods and compositions for diagnosing and/or treating cancer by targeting CCR8. In particular, the present invention provides technologies for depleting Treg cells, and particularly tumor-infiltrating Treg cells.
    Type: Grant
    Filed: April 28, 2015
    Date of Patent: October 2, 2018
    Assignee: Memorial Sloan Kettering Cancer Center
    Inventors: Alexander Rudensky, George Plitas
  • METHODS AND COMPOSITIONS FOR INDUCING REGULATORY T-CELL GENERATION
    Publication number: 20160271086
    Abstract: The present invention provides, among other things, methods and compositions for modulating inflammation. The present invention is based, in part, on the surprising discovery that peripheral regulatory T cells (pTreg), can be induced to differentiate after exposure to bacterial metabolites. In some embodiments, provided methods and compositions are used to treat diseases resulting from inflammation.
    Type: Application
    Filed: October 31, 2014
    Publication date: September 22, 2016
    Inventors: Alexander Rudensky, Nicholas Arpaia
  • METHODS AND COMPOSITIONS FOR REGULATORY T-CELL ABLATION
    Publication number: 20160237159
    Abstract: The present invention provides, among other things, methods and compositions for the treatment of cancer. The present invention is based, in part, on the surprising discovery that ablation of regulatory T cells (Treg), for example, transient ablation of Treg, is able to drastically reduce tumor burden and reduce metastasis when used as a single agent. In some embodiments, provided methods and compositions are used in combination with one or more other anti-tumor therapies, for example, ionizing radiation.
    Type: Application
    Filed: October 10, 2014
    Publication date: August 18, 2016
    Inventors: Paula D. Bos, Alexander Rudensky