ALEXANDER RYAN MANKOVICH has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210110883
    Abstract: Various embodiments relate to a method and apparatus for building a pedigree for a disease based on a family tree, the method comprising the steps of receiving, by a pedigree service, a family health condition request, transmitting, by the pedigree service, a request for the family tree, transmitting, by the pedigree service, a data request for health conditions of relatives on the family tree to an access control system, verifying, by the access control system, consent of the relatives on the family tree, receiving, by the pedigree service, health conditions of the relatives from a health data storage and drawing, by the pedigree service, a pedigree for the disease based on the health conditions of the relatives.
    Type: Application
    Filed: June 24, 2019
    Publication date: April 15, 2021
    Inventors: Jin Qu, Fubiao Xia, Alexander Ryan Mankovich, Raymond J. Krasinski
  • Publication number: 20200242148
    Abstract: Methods and systems for constructing a query. The methods and systems described herein provide novel techniques for constructing queries by mapping ontologies to each other. Accordingly, systems and methods described herein may map an otherwise unmappable term to an ontology in order to capitalize on the knowledge contained therein.
    Type: Application
    Filed: September 19, 2018
    Publication date: July 30, 2020
    Inventors: Alexander Ryan Mankovich, Woei-Jye Yee
  • Publication number: 20200234801
    Abstract: A method (100) for recruiting a patient for a clinical trial, comprising: receiving (110) a dataset comprising information about one or more clinical trials each including patient eligibility criteria; extracting (120) the patient eligibility criteria from each of the clinical trials; converting (130) the patient eligibility criteria to a standardized patient eligibility criterion using a structured clinical trial mark-up language; storing (140) the patient eligibility criterion in a database (862), each of the criterion associated with one or more clinical trials; receiving (150) patient-specific data values about a patient; querying (160) the clinical trial eligibility criteria database using the patient-specific data values to identify eligibility criterion satisfied by the patient-specific data value; identifying (170) a clinical trial associated with the one or more standardized patient eligibility criterion satisfied by a received patient-specific data value; and providing (180) a report of the identifi
    Type: Application
    Filed: October 5, 2018
    Publication date: July 23, 2020
    Inventors: Yong Mao, Woei-Jye Yee, Alexander Ryan Mankovich, Qingxin Wu, Kostyantyn Volyanskyy, Nevenka Dimitrova
  • Publication number: 20200020423
    Abstract: A system and method for providing a prioritized list of clinical trials that are relevant to a patient suffering from an illness or disease, such as cancer, are disclosed. Specifically, a method for conducting an automated, real time clinical trial search and a prioritization analysis is described. The method comprises the steps of conducting an automated full-text clinical trial search based on structuralization of clinical trial eligibility data and knowledge-based inference, initiating a query from the patient's side, and providing a prioritized list of all accessible clinical trials fulfilling a particular query. The system provides better sensitivity, precision and negative predictive value than the current most known clinical trial matching tool:
    Type: Application
    Filed: September 26, 2017
    Publication date: January 16, 2020
    Inventors: Qingxin Wu, Alexander Ryan Mankovich, Abhishek Talluli, Kostyantyn Volyanskyy, Nevenka Dimitrova, Yong Mao, Charles Yee
  • Publication number: 20200020421
    Abstract: A clinical genomic data processing device includes at least one microprocessor (10) and a non-transitory storage medium (12) storing instructions to implement functions of the device. A user interface (26, 28) receives requests for execution of genomic workflows and to display output generated by the execution of the genomic workflows. A genomic workflow manager manages an asynchronous messaging queue (24) and manages the execution of the genomic workflows. Service providers (20) performs jobs associated with the genomic workflows. The genomic workflow manager communicates with the service providers by messages exchanged via the asynchronous messaging queue to manage the execution of the genomic workflows via jobs performed by the service providers.
    Type: Application
    Filed: September 29, 2017
    Publication date: January 16, 2020
    Inventors: Nevenka Dimitrova, Ronen Solomon, Keswarpu Payal, Mine Danisman-Tasar, Moran Bentzur, Nadav Sharabi, Sergey Yussim, Alexander Ryan Mankovich, Vartika Agrawal, Julie Gu, Iliya Fridman, Kostyantyn Volyanskyy
  • Patent number: 10528758
    Abstract: Methods and apparatus for a secure framework for storing and analyzing genomic data. Embodiments of the present invention apply persistent governance to sensitive information and to the analytics that operate upon it, managing the interaction between the two.
    Type: Grant
    Filed: April 24, 2015
    Date of Patent: January 7, 2020
    Assignees: Koninklijke Philips N.V., Intertrust Technologies Corporation
    Inventors: Nevenka Dimitrova, William Knox Carey, Raymond J. Krasinski, Jarl Nilsson, Bart Grantham, Alexander Ryan Mankovich, Vartika Agrawal
  • Publication number: 20190362807
    Abstract: A genetic sequencer (10) generates DNA reads (16) from a tissue sample of a current patient. The DNA reads are aligned (18) with a reference DNA sequence (20) to generate a DNA sequence (22) of the current patient. Variant calling (24) is performed to generate a list of genetic variants (26) contained in the DNA sequence of the current patient. Occurrences are determined of genetic variants in one or more reference databases (44) storing genetic variants of medical patients. It is determined whether genetic variants of the list of genetic variants are synonymous. Scores are assigned for genetic variants based at least on measures of correlation of the genetic variants with disease. A ranked list (32) of top-scoring genetic variants is generated based on the assigned scores, and the ranked list is displayed on a display (36).
    Type: Application
    Filed: September 28, 2017
    Publication date: November 28, 2019
    Inventor: Alexander Ryan Mankovich
  • Publication number: 20190163918
    Abstract: A method for assessing risk associated with a request from an inquirer for allele frequency from a database of genetic data, comprising: (i) generating an allele database comprising allele frequency information and request frequency information for each of a plurality of alleles; (ii) generating an inquirer database comprising allele request information about a plurality of inquirers; (iii) receiving a request for genetic data from an inquirer, comprising a request for allele frequency for one or more alleles and an identifier of the inquirer; (iv) updating the request frequency information based on the received request; (v) updating the allele request information for the requesting inquirer; (vi) calculating an allele risk score; (vii) calculating an inquirer risk score; and (viii) assessing, based on the allele risk score and the inquirer risk score, a risk associated with the received request.
    Type: Application
    Filed: November 26, 2018
    Publication date: May 30, 2019
    Inventors: Jin Qu, Fubiao Xia, Yong Mao, Alexander Ryan Mankovich, Raymond J. Krasinski
  • Publication number: 20190079938
    Abstract: In patient cohort identification, clustering (30) of patients is performed using a patient comparison metric dependent on a set of features (24). Information is displayed on sample patients who are similar or dissimilar to a query patient according to the clustering. User inputted comparison values are received comparing the sample patients with the query patient. The set of features and/or feature weights are adjusted to generate an adjusted patient comparison metric having improved agreement with the user inputted comparison values. The clustering is repeated using the adjusted patient comparison metric. A patient cohort is identified from a cluster (34) containing the query patient produced by the last clustering repetition. The information on the sample patients may be shown by simultaneously displaying two or more graphical modality representations (70, 72, 74) each plotting the sample patients and the query patient against two or more features of the modality.
    Type: Application
    Filed: March 8, 2017
    Publication date: March 14, 2019
    Inventors: Vartika Agrawal, Alexander Ryan Mankovich, Nevenka Dimitrova, Nilanjana Banerjee, Yee Him Cheung, Johanna Maria De Bont, Jozef Hieronymus Maria Raijmakers
  • Publication number: 20170286597
    Abstract: Methods and systems for visualizing gene expression data in a way that permits the comparison of different patient groups to facilitate medical applications, including cancer diagnostics and treatment planning, particularly breast cancer. The method organises gene expression data for at least one patient into a plurality of windows of a specified size, calculates an average RSEM score for all of the genes in each window and presents the average RSEM scores in a two-dimensional array, wherein one axis organises the windows by patient and the other axis organises the windows by sequence.
    Type: Application
    Filed: August 17, 2015
    Publication date: October 5, 2017
  • Publication number: 20170068826
    Abstract: Methods and apparatus for a secure framework for storing and analyzing genomic data. Embodiments of the present invention apply persistent governance to sensitive information and to the analytics that operate upon it, managing the interaction between the two.
    Type: Application
    Filed: April 24, 2015
    Publication date: March 9, 2017
  • Publication number: 20160070858
    Abstract: Clinical decision support visualization methods that use information, pathways, or inferred regulatory networks for the entire genome, transcriptome, exome, or methylome to highlight genomic activity to further the understanding of the clinical condition of a patient or to contrast different patient groups.
    Type: Application
    Filed: September 2, 2015
    Publication date: March 10, 2016