Abstract: A genetic sequencer (10) generates DNA reads (16) from a tissue sample of a current patient. The DNA reads are aligned (18) with a reference DNA sequence (20) to generate a DNA sequence (22) of the current patient. Variant calling (24) is performed to generate a list of genetic variants (26) contained in the DNA sequence of the current patient. Occurrences are determined of genetic variants in one or more reference databases (44) storing genetic variants of medical patients. It is determined whether genetic variants of the list of genetic variants are synonymous. Scores are assigned for genetic variants based at least on measures of correlation of the genetic variants with disease. A ranked list (32) of top-scoring genetic variants is generated based on the assigned scores, and the ranked list is displayed on a display (36).

Abstract: Various systems and methods are provided that display various geographic maps and depth graphs in an interactive user interface in substantially real-time in response to input from a user in order to determine information related to measured data points, depth levels, and geological layers and provide the determined information to the user in the interactive user interface. For example, a computing device may be configured to retrieve data from one or more databases and generate one or more interactive user interfaces. The one or more interactive user interfaces may display the retrieved data in a geographic map, a heat map, a cross-plot graph, or one or more depth graphs. The user interface may be interactive in that a user may manipulate any of the graphs to identify trends or current or future issues.

Abstract: A system includes a trailer frame, a lifting mechanism coupled to the trailer frame, wherein the lifting mechanism is configured to raise or lower a coil of pipe or a reel of pipe, a braking mechanism configured to apply pressure to the pipe while the pipe is being deployed by the system, and a hydraulic power unit configured to hydraulically power the system.

Abstract: A method for assessing risk associated with a request from an inquirer for allele frequency from a database of genetic data, comprising: (i) generating an allele database comprising allele frequency information and request frequency information for each of a plurality of alleles; (ii) generating an inquirer database comprising allele request information about a plurality of inquirers; (iii) receiving a request for genetic data from an inquirer, comprising a request for allele frequency for one or more alleles and an identifier of the inquirer; (iv) updating the request frequency information based on the received request; (v) updating the allele request information for the requesting inquirer; (vi) calculating an allele risk score; (vii) calculating an inquirer risk score; and (viii) assessing, based on the allele risk score and the inquirer risk score, a risk associated with the received request.

Abstract: A system may determine one or more data sources which the system is configured to access. The system may provide a set of application programming interfaces (APIs) for interacting with data stored in one or more data sources. The APIs may be accessible to one or more web applications which the system is configured to serve. The system may determine that a web application has requested an operation for interacting with the data through one or more APIs in the set of APIs. The system may determine one or more responses based at least in part on the operation requested by the web application. The system may provide the response(s) to the web application.

Abstract: In patient cohort identification, clustering (30) of patients is performed using a patient comparison metric dependent on a set of features (24). Information is displayed on sample patients who are similar or dissimilar to a query patient according to the clustering. User inputted comparison values are received comparing the sample patients with the query patient. The set of features and/or feature weights are adjusted to generate an adjusted patient comparison metric having improved agreement with the user inputted comparison values. The clustering is repeated using the adjusted patient comparison metric. A patient cohort is identified from a cluster (34) containing the query patient produced by the last clustering repetition. The information on the sample patients may be shown by simultaneously displaying two or more graphical modality representations (70, 72, 74) each plotting the sample patients and the query patient against two or more features of the modality.

Abstract: A structure and method of operation of a journal bearing is disclosed that minimizes contact of the shaft with the sleeve during start up and slow down of the rotation of the shaft relative to the sleeve, or vice versa. The bearing assembly includes a gravitational load reduction mechanism with magnets disposed on the sleeve and on the shaft in alignment with one another. The magnet(s) on the shaft interacts with the magnet(s) disposed on the sleeve to provide a force against the pressure of the shaft towards the sleeve generated by gravity acting on the rotating component. The magnets enable centering of the rotating component within the stationary component during low rotation and non-rotation. This prevents rubbing of the rotating journal bearing component surfaces, e.g., sleeve, against the stationary journal bearing component, e.g., shaft, during assembly, ramp-up, and coast-down when the journal bearing fluid provides minimal or no bearing centering capability.

Abstract: A system may determine one or more data sources which the system is configured to access. The system may provide a set of application programming interfaces (APIs) for interacting with data stored in one or more data sources. The APIs may be accessible to one or more web applications which the system is configured to serve. The system may determine that a web application has requested an operation for interacting with the data through one or more APIs in the set of APIs. The system may determine one or more responses based at least in part on the operation requested by the web application. The system may provide the response(s) to the web application.

Abstract: A system includes a trailer frame, a lifting mechanism coupled to the trailer frame, wherein the lifting mechanism is configured to raise or lower a coil of pipe or a reel of pipe, a braking mechanism configured to apply pressure to the pipe while the pipe is being deployed by the system, and a hydraulic power unit configured to hydraulically power the system.

Abstract: Various systems and methods are provided that display various geographic maps and depth graphs in an interactive user interface in substantially real-time in response to input from a user in order to determine information related to measured data points, depth levels, and geological layers and provide the determined information to the user in the interactive user interface. For example, a computing device may be configured to retrieve data from one or more databases and generate one or more interactive user interfaces. The one or more interactive user interfaces may display the retrieved data in a geographic map, a heat map, a cross-plot graph, or one or more depth graphs. The user interface may be interactive in that a user may manipulate any of the graphs to identify trends or current or future issues.

Abstract: A system may determine one or more data sources which the system is configured to access. The system may provide a set of application programming interfaces (APIs) for interacting with data stored in one or more data sources. The APIs may be accessible to one or more web applications which the system is configured to serve. The system may determine that a web application has requested an operation for interacting with the data through one or more APIs in the set of APIs. The system may determine one or more responses based at least in part on the operation requested by the web application. The system may provide the response(s) to the web application.

Abstract: Systems and methods for creating and using a workflow template for analyzing data entities stored in the one or more databases. After a desired workflow is identified, one or more series, data source, and/or entity restrictions based upon the workflow may be received. In addition, one or more chart configuration settings based upon the workflow may also be received. The restrictions and configuration settings may be saved as the workflow template. The workflow may then be performed by loading the saved workflow template, in order to automatically generate charts in accordance with the configuration settings of the template, based upon a received selection of series, data sources, and entities that adheres to the restrictions defined in the template.

Abstract: A band cutter assembly and related methods for cutting bands used to bind coils of flexible pipe used in the oil and gas industry are provided. Band-cutter assembly can be disposed on a coil deployment apparatus, or alternatively, can be disposed on a separate apparatus that is disposed on and/or adjacent to a coil deployment apparatus and capable of bringing the band-cutter assembly into proximity with retaining bands on a coil of flexible pipe.

Abstract: Various systems and methods are provided that display various geographic maps and depth graphs in an interactive user interface in substantially real-time in response to input from a user in order to determine information related to measured data points, depth levels, and geological layers and provide the determined information to the user in the interactive user interface. For example, a computing device may be configured to retrieve data from one or more databases and generate one or more interactive user interfaces. The one or more interactive user interfaces may display the retrieved data in a geographic map, a heat map, a cross-plot graph, or one or more depth graphs. The user interface may be interactive in that a user may manipulate any of the graphs to identify trends or current or future issues.

Abstract: Systems and methods for creating and using a workflow template for analyzing data entities stored in the one or more databases. After a desired workflow is identified, one or more series, data source, and/or entity restrictions based upon the workflow may be received. In addition, one or more chart configuration settings based upon the workflow may also be received. The restrictions and configuration settings may be saved as the workflow template. The workflow may then be performed by loading the saved workflow template, in order to automatically generate charts in accordance with the configuration settings of the template, based upon a received selection of series, data sources, and entities that adheres to the restrictions defined in the template.

Abstract: Methods and systems for visualizing gene expression data in a way that permits the comparison of different patient groups to facilitate medical applications, including cancer diagnostics and treatment planning, particularly breast cancer. The method organises gene expression data for at least one patient into a plurality of windows of a specified size, calculates an average RSEM score for all of the genes in each window and presents the average RSEM scores in a two-dimensional array, wherein one axis organises the windows by patient and the other axis organises the windows by sequence.

Abstract: A projectile resistant desk. The desk includes a desktop support having a receptacle and a removable desktop hingedly coupled to a slip rod; wherein the slip rod substantially corresponds to the receptacle and allows the desktop to be removably secured to the desktop support. The projectile resistant desk is suited for frame styled or storage styled supports. The desktop can be made of a variety of materials including bullet-resistant glass, polycarbonates, polyurethane, fiberglass and resins and can include one or more handles on its underside. The desk can further include a projectile resistant leg shield.

Abstract: Methods and apparatus for a secure framework for storing and analyzing genomic data. Embodiments of the present invention apply persistent governance to sensitive information and to the analytics that operate upon it, managing the interaction between the two.

Abstract: Systems and methods for creating and using a workflow template for analyzing data entities stored in the one or more databases. After a desired workflow is identified, one or more series, data source, and/or entity restrictions based upon the workflow may be received. In addition, one or more chart configuration settings based upon the workflow may also be received. The restrictions and configuration settings may be saved as the workflow template. The workflow may then be performed by loading the saved workflow template, in order to automatically generate charts in accordance with the configuration settings of the template, based upon a received selection of series, data sources, and entities that adheres to the restrictions defined in the template.

Abstract: Clinical decision support visualization methods that use information, pathways, or inferred regulatory networks for the entire genome, transcriptome, exome, or methylome to highlight genomic activity to further the understanding of the clinical condition of a patient or to contrast different patient groups.