Patents by Inventor Alexander Schinagl

Alexander Schinagl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IMPROVED ANTI-oxMIF ANTIBODIES WITH REDUCED AGGREGATION POTENTIAL AND REDUCED HYDROPHOBICITY
    Publication number: 20230365671
    Abstract: The invention refers to anti-oxMIF antibodies with improved properties such as reduced aggregation potential and reduced hydrophobicity due to selected amino acid substitutions in the light and heavy chain variable domains and optionally increased effector functions due to further substitutions in the heavy chain constant regions, and their use in the treatment of oxMIF-related conditions.
    Type: Application
    Filed: October 1, 2021
    Publication date: November 16, 2023
    Inventors: Alexander SCHINAGL, Irina MIRKINA, Randolf KERSCHBAUMER, Robert Michael THIELE
  • ANTI-oxMIF/ANTI-CD3 BISPECIFIC ANTIBODY CONSTRUCTS
    Publication number: 20230045873
    Abstract: The invention refers to an anti-oxMIF/anti-CD3 antibody comprising at least one binding site specifically recognizing oxMIF and one binding site specifically recognizing CD3, which is an IgG wherein a scFv is fused to only one of the two heavy IgG chains, an IgG wherein one Fab arm is replaced by a bispecific-T-cell-engager (BiTE), or an IgG wherein both Fab arms are replaced by scFvs with different binding specificities, and its use in the treatment of hyperproliferative diseases, specifically in the treatment of cancer.
    Type: Application
    Filed: December 4, 2020
    Publication date: February 16, 2023
    Inventors: Alexander SCHINAGL, Michael Robert THIELE, Randolf KERSCHBAUMER
  • Anti-MIF immunohistochemistry
    Patent number: 11402388
    Abstract: The present invention pertains to the specific detection of MIF, in particular oxMIF, in tissues. A detection method is provided which uses immunohistochemistry and wherein specific anti-oxMIF antibodies are used.
    Type: Grant
    Filed: July 9, 2013
    Date of Patent: August 2, 2022
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Michael Thiele, Randolf Kerschbaumer, Dirk Voelkel, Patrice Douillard, Friedrich Scheiflinger, Alexander Schinagl
  • ANTI-oxMIF/ANTI-CD3 ANTIBODY FOR CANCER TREATMENT
    Publication number: 20220002398
    Abstract: The invention refers to an anti-ox MIF/anti-CD3 antibody comprising at least one binding site specifically recognizing ox MIF and at least one binding site specifically recognizing CD3 and its use in the treatment of hyperproliferative diseases, specifically in the treatment of cancers.
    Type: Application
    Filed: June 7, 2019
    Publication date: January 6, 2022
    Inventors: Michael Robert THIELE, Alexander SCHINAGL, Randolf KERSCHBAUMER
  • Anti-MIF immunohistochemistry
    Patent number: 10613100
    Abstract: The present invention pertains to the specific detection of MIF, in particular oxMIF, and of anti-oxMIF antibodies in tissues. A detection method is provided which uses immunohistochemistry or immunofluorescence and wherein specific anti-oxMIF antibodies and specific idiotypic monoclonal rabbit antibodies are used.
    Type: Grant
    Filed: January 2, 2015
    Date of Patent: April 7, 2020
    Assignees: Baxalta Incorporated, Baxalta GmbH
    Inventors: Alexander Schinagl, Michael Thiele, Patrice Douillard, Gerhard Antoine, Randolf Kerschbaumer
  • ANTI-MIF IMMUNOHISTOCHEMISTRY
    Publication number: 20160334414
    Abstract: The present invention pertains to the specific detection of MIF, in particular oxMIF, and of anti-oxMIF antibodies in tissues. A detection method is provided which uses immunohistochemistry or immunofluorescence and wherein specific anti-oxMIF antibodies and specific idiotypic monoclonal rabbit antibodies are used.
    Type: Application
    Filed: January 2, 2015
    Publication date: November 17, 2016
    Inventors: Alexander Schinagl, Michael Thiele, Patrice Douillard, Gerhard Antoine, Randolf Kerschbaumer
  • ANTI-MIF IMMUNOHISTOCHEMISTRY
    Publication number: 20150160235
    Abstract: The present invention pertains to the specific detection of MIF, in particular oxMIF, in tissues. A detection method is provided which uses immunohistochemistry and wherein specific anfi-oxMIF antibodies are used.
    Type: Application
    Filed: July 9, 2013
    Publication date: June 11, 2015
    Inventors: Michael Thiele, Randolf Kerschbaumer, Dirk Voelkel, Patrice Douillard, Friedrich Scheiflinger, Alexander Schinagl