Abstract: According to some embodiments, methods and systems may be associated with a cloud computing environment. A workload prediction framework may receive observed workload information associated with a database in the cloud computing environment (e.g., a DataBase as a Service (“DBaaS”)). Based on the observed workload information, a Statement Arrival Rate (“SAR”) prediction may be generated. In addition, a host variable assignment prediction may be generated based on the observed workload information. The workload prediction framework may then use the SAR prediction and the host variable assignment prediction to automatically create a workload prediction for the database. A physical database design advisor (e.g., a table partitioning advisor) may receive the workload prediction and, responsive to the workload prediction, automatically generate a recommended physical layout for the database (e.g., using a cost model, the current physical layout, and an objective function).

Abstract: An air-conditioning system for an electrically drivable motor vehicle includes a first vehicle component to be temperature-controlled, a second vehicle component to be temperature-controlled, which is arranged on at least one cooling body, and a heat transport medium-carrying first circuit, which is provided for controlling the temperature of the vehicle components and to which the first vehicle component and the at least one cooling body of the second vehicle component are connected. A heating device which is configured to release heating energy to the heat transport medium is arranged on the at least one cooling body, wherein via the heat transport medium, the heating energy can be transported at least partially to the first vehicle component for the purpose of heating the first vehicle component.

Abstract: An air-conditioning system for an electrically drivable motor vehicle includes a first vehicle component to be temperature-controlled, a second vehicle component to be temperature-controlled, which is arranged on at least one cooling body, and a heat transport medium-carrying first circuit, which is provided for controlling the temperature of the vehicle components and to which the first vehicle component and the at least one cooling body of the second vehicle component are connected. A heating device which is configured to release heating energy to the heat transport medium is arranged on the at least one cooling body, wherein via the heat transport medium, the heating energy can be transported at least partially to the first vehicle component for the purpose of heating the first vehicle component.

Abstract: A round-trip autoclave sample-extracting device for extracting a sample at a sample extraction location of a geological formation, the device includes a self-closing pressure chamber module for receiving the sample. The pressure chamber module is connected to a lifting module in order to lift the sample into the pressure chamber module in one sampling stroke. The round-trip autoclave sample-extracting device has a triggering module and a pressure regulating module, the triggering module acting on the lifting module in order to trigger the sampling stroke, and the pressure regulating module is coupled to the pressure chamber module at least on the pressure side after the sampling stroke in order to influence a pressure in the pressure chamber module. A round-trip method is proposed which includes a first trip and at least one second trip for extracting a sample while maintaining a pressure that is present at the sample extraction location.

Abstract: The invention provides compounds that are effective as inhibitors of human plasmin and plasma kallikrein, and that are useful for the prevention of blood loss and as components of fibrin adhesives. The invention further provides methods of making and using the compounds.

Abstract: The invention relates to a method and a device for optically measuring the interior of a seamless pipe which is manufactured by rolling or of a pipe which is welded with a longitudinal seam and is manufactured from sheet-metal plates shaped to form half-shells or from a shaped sheet-metal plate or from a metal strip which is unwound from a coil, comprising a sensor means (9) which emits a laser beam (10) in the interior of the pipe (3). In such a method and device, an internal measurement of seamless pipes or pipes which are welded with a longitudinal seam is to be provided with which it is easily possible to determine and model precisely the ovalness and straightness of the pipe (3) in a station.

Abstract: The invention relates to a machine for machining the ends of pipes which, for control purposes, is assigned at least one computer unit and in the case of which the tools (13) are arranged displaceably such that they can engage radially in relation to the pipe in a tool head (11) which is driven by a motor (4) via a main spindle (10) guided through a headstock (6), the tool head rotating coaxially about the fixedly clamped pipe end, wherein the tools are arranged in tool holders in the form of slides (14A, 14B; 15A, 15B; 16A, 16B) and adjacent slides together mesh with a toothed wheel which is formed with weight compensation. According to the invention, the tool head (11) is formed with integrated advance motors (17) assigned to the slides (14A, 14B; 15A, 15B; 16A, 16B), and each slide is assigned a measuring device (24).

Abstract: The invention relates to a machine for machining the ends of pipes which, for control purposes, is assigned at least one computer unit and in the case of which the tools (13) are arranged displaceably such that they can engage radially in relation to the pipe in a tool head (11) which is driven by a motor (4) via a main spindle (10) guided through a headstock (6), the tool head rotating coaxially about the fixedly clamped pipe end, wherein the tools are arranged in tool holders in the form of slides (14A, 14B; 15A, 15B; 16A, 16B) and adjacent slides together mesh with a toothed wheel which is formed with weight compensation. According to the invention, the tool head (11) is formed with integrated advance motors (17) assigned to the slides (14A, 14B; 15A, 15B; 16A, 16B), and each slide is assigned a measuring device (24).

Abstract: The invention relates to a method and a device for optically measuring the interior of a seamless pipe which is manufactured by rolling or of a pipe which is welded with a longitudinal seam and is manufactured from sheet-metal plates shaped to form half-shells or from a shaped sheet-metal plate or from a metal strip which is unwound from a coil, comprising a sensor means (9) which emits a laser beam (10) in the interior of the pipe (3). In such a method and device, an internal measurement of seamless pipes or pipes which are welded with a longitudinal seam is to be provided with which it is easily possible to determine and model precisely the ovalness and straightness of the pipe (3) in a station.

Abstract: A round-trip autoclave sample-extracting device for extracting a sample at a sample extraction location of a geological formation, the device includes a self-closing pressure chamber module for receiving the sample. The pressure chamber module is connected to a lifting module in order to lift the sample into the pressure chamber module in one sampling stroke. The round-trip autoclave sample-extracting device has a triggering module and a pressure regulating module, the triggering module acting on the lifting module in order to trigger the sampling stroke, and the pressure regulating module is coupled to the pressure chamber module at least on the pressure side after the sampling stroke in order to influence a pressure in the pressure chamber module. A round-trip method is proposed which includes a first trip and at least one second trip for extracting a sample while maintaining a pressure that is present at the sample extraction location.

Abstract: The invention provides compounds that are effective as inhibitors of human plasmin and plasma kallikrein, and that are useful for the prevention of blood loss and as components of fibrin adhesives. The invention further provides methods of making and using the compounds.

Abstract: The invention relates to compounds of general formula 1 to processes for the production thereof, to pharmaceutical preparations containing said compounds and/or physiologically compatible salts and/or solvates which can be produced therefrom as well as to the pharmaceutical use of said compounds, the salts or solvates thereof as inductors of apoptosis in the case of non-solid malignant tumors of the hematopoietic system, in particular in the case of leukemias and lymphomas, more particularly in the case of leukemic B lymphocytes.

Abstract: The invention provides compounds that are effective as inhibitors of human plasmin and plasma kallikrein, and that are useful for the prevention of blood loss and as components of fibrin adhesives. The invention further provides methods of making and using the compounds.

Abstract: The invention relates to inhibitors of trypsin-like serine proteases, including those of the general formula (IV) which, as well as plasmin, also inhibit plasma kallikrien, and to their use as medicaments, preferably for treatment of blood loss, especially in the case of hyperfibrinolytic states, in organ transplants or heart surgery interventions, in particular with a cardiopulmonary bypass, or as a constituent of a fibrin adhesive.

Abstract: The invention provides methods of making and using compounds of the formula: or a pharmaceutically acceptable salt thereof; wherein n is an integer between 1 and 2 inclusively; m is an integer between 0 and 2 inclusively; X is selected from the group consisting of CH or N; R1 is selected from the group consisting of —CH2NH2, and R2 is selected from the group consisting of —H, —OH, —NH2 and acetyl; R3 is selected from the group consisting of —H, benzyloxycarbonyl and benzylsulfonyl; and R4 is selected from the group consisting of —OH, wherein p is an integer between 0 and 2 inclusively, Y is selected from the group consisting of —O—, —S—, —S(?O)—, —SO2—, methylene, —CH(OH)—, —CH(NH2)—, —CH(CH2—OH)—, —CH(CH2—NH2)— or —N(R6)—, R5 is selected from the group consisting of —H or a simple (C1-C3) alkyl and R6 is selected from the group consisting of —H, a simple (C1-C3) alkyl or a simple (C1-C3) acyl.

Abstract: The invention relates to inhibitors of trypsin-like serine proteases of the general formula (I) which, as well as plasmin, also inhibit plasma kallikrein, and to their preparation and use as medicaments, preferably for treatment of blood loss, especially in the case of hyperfibrinolytic states, in organ transplants or heart surgery interventions, in particular with a cardiopulmonary bypass, or as a constituent of a fibrin adhesive.

Abstract: The invention provides methods of making and using compounds of the formula: or a pharmaceutically acceptable salt thereof; wherein n is an integer between 1 and 2 inclusively; m is an integer between 0 and 2 inclusively; X is selected from the group consisting of CH or N; R1 is selected from the group consisting of —CH2NH2, and R2 is selected from the group consisting of —H, —OH, —NH2 and acetyl; R3 is selected from the group consisting of —H, benzyloxycarbonyl and benzylsulfonyl; and R4 is selected from the group consisting of —OH, wherein p is an integer between 0 and 2 inclusively, Y is selected from the group consisting of —O—, —S—, —S(?O)—, —SO2—, methylene, —CH(OH)—, —CH(NH2)—, —CH(CH2—OH)—, —CH(CH2—NH2)— or —N(R6)—, R5 is selected from the group consisting of —H or a simple (C1-C3) alkyl and R6 is selected from the group consisting of —H, a simple (C1-C3) alkyl or a simple (C1-C3) acyl.

Abstract: The invention relates to inhibitors of trypsin-like serine proteases of the general formula (I) which, as well as plasmin, also inhibit plasma kallikrein, and to their preparation and use as medicaments, preferably for treatment of blood loss, especially in the case of hyperfibrinolytic states, in organ transplants or heart surgery interventions, in particular with a cardiopulmonary bypass, or as a constituent of a fibrin adhesive.

Abstract: The invention relates to inhibitors of trypsin-like serine proteases of the general formula (I) which, as well as plasmin, also inhibit plasma kallikrien, and to their preparation and use as medicaments, preferably for treatment of blood loss, especially in the case of hyperfibrinolytic states, in organ transplants or heart surgery interventions, in particular with a cardiopulmonary bypass, or as a constituent of a fibrin adhesive.

Abstract: The invention relates to compounds of general formula (I); 1a, 1b, 1c and 1d. The invention also relates to a method for the production thereof, pharmaceutical preparations containing said compounds and/or physiologically compatible salts thereof which can be produced therefrom and/or solvates thereof, and to the pharmaceutical use of said compounds, salts or solvates thereof as inhibitors of phosphodiesterase 4. The compounds comprise active ingredients for the treatment of diseases which can have a positive influence by inhibiting the activity of phosphodiesterase 4 and/or TNF?-release, for example, in lymphocytes, eosinophile and basophile granulocytes, macrophages and mastocytes.