Patents by Inventor Alexander Seiler
Alexander Seiler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240108709Abstract: The present invention provides vaccine compositions and methods of producing such compositions. Other embodiments of the invention include methods of treating a pathogen infection, methods of vaccinating a subject against a pathogen infection, and methods for treating an antibiotic-resistance bacterial infection in a subject in need thereof. In further embodiments, the invention includes methods of decreasing the level of a pathogen in a subject having a pathogen infection, methods of increasing the surviving rate of a subject having a pathogen infection, methods of reducing the level of pain associated with a pathogen infection, and methods of reducing the level of distress associated with a pathogen infection in a subject in need thereof. Novel scaffold compositions and opsonin-bound or lectin-bound pathogen compositions, and uses thereof, are also provided herein.Type: ApplicationFiled: March 20, 2023Publication date: April 4, 2024Applicant: President and Fellows of Harvard CollegeInventors: Michael Super, Edward J. Doherty, Mark Joseph Cartwright, Des White, Alexander Stafford, Omar Abdel-Rahman Ali, Amanda Graveline, Donald E. Ingber, David J. Mooney, Benjamin Seiler
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Patent number: 11879904Abstract: A method of washing an aspiration probe of an in-vitro diagnostic system is disclosed. The aspiration probe comprises an outer surface and an inner surface forming an inner space for receiving a fluid. The method comprises dipping the aspiration probe into a first wash fluid so that the outer surface is immersed at least in part into the first wash fluid, aspirating an amount of the first wash fluid into the inner space of the aspiration probe, propagating an ultrasonic vibration to the outer surface of the aspiration probe via the first wash fluid, and rinsing the outer surface and the inner surface of the aspiration probe with a second wash fluid. Further, an in-vitro diagnostic method and an in-vitro diagnostic system are disclosed.Type: GrantFiled: October 22, 2021Date of Patent: January 23, 2024Assignees: Roche Diagnostics Operations, Inc., Hitachi High-Technologies CorporationInventors: Kouhei Nonaka, Takamichi Mori, Yoichi Aruga, Yosuke Horie, Andrew McCaughey, Alexander Seiler
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Publication number: 20230341426Abstract: An automatic analyzer is capable of reducing the time required for a series of maintenance operations in that the user’s maintenance work is linked to the device driving so that the maintenance work proceeds in the order of the maintenance work tools. An automatic analyzer includes a plurality of processing units for processing a specimen: an agitation mechanism, a reagent dispensing mechanism, a mixer, an incubator, and a specimen dispensing mechanism. A control unit controls a processing unit, an analysis unit, and a display unit and causes the display unit to display a plurality of maintenance work tools used for maintenance work performed by the operator on the plurality of processing units and to display the maintenance work contents of the plurality of processing units that continuously use one of the plurality of maintenance work tools, selected by the operator via the display unit.Type: ApplicationFiled: December 14, 2020Publication date: October 26, 2023Inventors: Yusuke MIZUKI, Marina NAKAI, Shunsuke SASAKI, Kenta IMAI, Alexander SEILER, Gertraud EHRLICH-WEINREICH
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Publication number: 20220113331Abstract: A method of washing an aspiration probe of an in-vitro diagnostic system is disclosed. The aspiration probe comprises an outer surface and an inner surface forming an inner space for receiving a fluid. The method comprises dipping the aspiration probe into a first wash fluid so that the outer surface is immersed at least in part into the first wash fluid, aspirating an amount of the first wash fluid into the inner space of the aspiration probe, propagating an ultrasonic vibration to the outer surface of the aspiration probe via the first wash fluid, and rinsing the outer surface and the inner surface of the aspiration probe with a second wash fluid. Further, an in-vitro diagnostic method and an in-vitro diagnostic system are disclosed.Type: ApplicationFiled: October 22, 2021Publication date: April 14, 2022Applicants: Roche Diagnostics Operations, Inc., Hitachi High-Technologies CorporationInventors: Kouhei Nonaka, Takamichi Mori, Yoichi Aruga, Yosuke Horie, Andrew McCaughey, Alexander Seiler
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Patent number: 11169169Abstract: A method of washing an aspiration probe of an in-vitro diagnostic system is disclosed. The aspiration probe comprises an outer surface and an inner surface forming an inner space for receiving a fluid. The method comprises dipping the aspiration probe into a first wash fluid so that the outer surface is immersed at least in part into the first wash fluid, aspirating an amount of the first wash fluid into the inner space of the aspiration probe, propagating an ultrasonic vibration to the outer surface of the aspiration probe via the first wash fluid, and rinsing the outer surface and the inner surface of the aspiration probe with a second wash fluid. Further, an in-vitro diagnostic method and an in-vitro diagnostic system are disclosed.Type: GrantFiled: June 7, 2019Date of Patent: November 9, 2021Assignees: ROCHE DIAGNOSTICS OPERATIONS, INC., HITACHI HIGH-TECH CORPORATIONInventors: Kouhei Nonaka, Takamichi Mori, Yoichi Aruga, Yosuke Horie, Andrew McCaughey, Alexander Seiler
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Publication number: 20190369132Abstract: A method of washing an aspiration probe of an in-vitro diagnostic system is disclosed. The aspiration probe comprises an outer surface and an inner surface forming an inner space for receiving a fluid. The method comprises dipping the aspiration probe into a first wash fluid so that the outer surface is immersed at least in part into the first wash fluid, aspirating an amount of the first wash fluid into the inner space of the aspiration probe, propagating an ultrasonic vibration to the outer surface of the aspiration probe via the first wash fluid, and rinsing the outer surface and the inner surface of the aspiration probe with a second wash fluid. Further, an in-vitro diagnostic method and an in-vitro diagnostic system are disclosed.Type: ApplicationFiled: June 7, 2019Publication date: December 5, 2019Applicants: Roche Diagnostics Operations, Inc., Hitachi High-Technologies CorporationInventors: Kouhei Nonaka, Takamichi Mori, Yoichi Aruga, Yosuke Horie, Andrew McCaughey, Alexander Seiler
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Patent number: 9200246Abstract: An insert device and co-culture device assembly incorporating the insert device, which includes an insert chamber with two fluid impermeable side walls that extend from a microporous bottom to an open top to form an inner cavity. The first side wall is shaped to form a convex arc that follows between about half of a circumference of the well and less than an entire circumference of the well. The second side wall joins ends of the first side wall and protrudes inward towards a center of the convex arc. A flange extends outward from or beneath the top and is notched to form a gap adjacent to the second side wall, which forms an access port allowing access to the lower chamber with a micropipette tip when the insert device is inserted into a well of a single or multi-well plate.Type: GrantFiled: December 1, 2011Date of Patent: December 1, 2015Assignee: ACEA Biosciences, Inc.Inventors: Donald Thomas, Wei Li, Ning Ke, Nan Li, Adrian Papas, Manfred Watzele, Alexander Seiler, Tianxing Wang, Yama Abassi, Xiaobo Wang
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Publication number: 20130143254Abstract: An insert device and co-culture device assembly incorporating the insert device, which includes an insert chamber with two fluid impermeable side walls that extend from a microporous bottom to an open top to form an inner cavity. The first side wall is shaped to form a convex arc that follows between about half of a circumference of the well and less than an entire circumference of the well. The second side wall joins ends of the first side wall and protrudes inward towards a center of the convex arc. A flange extends outward from or beneath the top and is notched to form a gap adjacent to the second side wall, which forms an access port allowing access to the lower chamber with a micropipette tip when the insert device is inserted into a well of a single or multi-well plate.Type: ApplicationFiled: December 1, 2011Publication date: June 6, 2013Applicants: ROCHE DIAGNOSTICS OPERATIONS, INC., ACEA BIOSCIENCES, INC.Inventors: Donald Thomas, Wei Li, Ning Ke, Nan Li, Adrian Papas, Manfred Watzele, Alexander Seiler, Tianxing Wang, Yama Abassi, Xiaobo Wang
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Patent number: D581811Type: GrantFiled: January 19, 2006Date of Patent: December 2, 2008Assignee: Rado Uhren AG (Rado Watch Co. Ltd.) (Montres Rado SA)Inventors: Stephan Messmer, Alexander Seiler
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Patent number: D588472Type: GrantFiled: June 22, 2007Date of Patent: March 17, 2009Assignee: Rado Uhren AG (Radio Watch Co. Ltd.) (Montres Rado SA)Inventors: Stephan Messmer, Alexander Seiler
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Patent number: D684703Type: GrantFiled: November 28, 2011Date of Patent: June 18, 2013Assignees: ACEA Biosciences, Inc., Roche Diagnostics Operations, Inc.Inventors: Manfred Watzele, Alexander Seiler, Donald Thomas, Wei Li, Tianxing Wang, Nan Li, Xiaobo Wang