Abstract: A device for producing a 3D-printed active substance-releasing system with active substance depots, such that a radiation source in operation causes a polymerisation of a layer of the base material on the construction platform and that an inkjet printhead incorporates an active substance mixture, which has at least one active substance, into the base material in a locationally selective manner. A trough is provided, in which a base material and a construction platform are arranged, and polymerising selected regions of a layer of the base material on the construction platform and introducing, by means of an inkjet printing method, an active substance mixture, which has at least one active substance, into the base material and/or polymerised base material in a locationally selective manner in order to thereby create active ingredient depots in the active ingredient-releasing system.

Abstract: A method for separating blanks includes continuous conveying of a sheet metal strip in a transport direction to a laser cutting station, concurrent cutting of the sheet metal strip by at least one cutting laser, wherein a cut sheet metal strip is formed from successive sections of the same cutting geometry, transporting the cut sheet metal strip on a first conveyor belt in the transport direction, taking over the cut sheet metal strip from the first conveyor belt, transporting the cut sheet metal strip in the transport direction, separately ejecting the at least one residual blank of each section, transporting the at least one blank of each section into overlap with a second conveyor belt and ejecting the at least one blank from the suction conveyor, and transporting the blanks ejected one after the other from the suction conveyor horizontally in the transport direction to a collecting station.

Abstract: The invention relates to a method for cutting a sheet metal blank from a sheet metal strip (1) continuously conveyed in a transport direction (T), by means of at least one laser cutting device (3), having the following steps: providing a laser cutting device (3) with at least one laser cutting head (5) which has a cutting nozzle (7) and which can be moved along a cutting path (S1, S2, S1?, S2?) specified so as to correspond to the geometry of the sheet metal blank by means of a controller (6), incrementally measuring the distance between the cutting nozzle (7) and the surface of the sheet metal strip (1) at at least one radially outer position (P1, P2) relative to the cutting nozzle (7) by means of a first distance measuring device (8), controlling the movement of the laser cutting head such that the first distance measuring device (8, 9) constantly remains overlapping the sheet metal strip (1), into a second position, in which the cutting nozzle is overlapping the sheet metal strip (1), wherein the height

Abstract: A method of generating transcribed nucleic acids, comprising the steps of hybridizing an oligonucleotide probe to a nucleic acid template, wherein said oligonucleotide probe comprises a noncomplementary part in 5? direction of the complementary part that does not hybridize to the nucleic acid template and comprises a sequence of a transcription promoter, hydrolysing a 3? part of the nucleic acid template that is in 3? direction to a part of the nucleic acid template that hybridizes to the oligonucleotide probe and wherein said 3? part is not hybridized to the oligonucleotide probe, extending the nucleic acid template with nucleic acids complementary to the non-complementary part of the oligonucleotide probe, thereby generating a duplex of the sequence of the transcription promoter in sequence with the nucleic acid template, and transcribing the nucleic acid template with a transcriptase that binds the duplex of the sequence of the transcription promoter.

Abstract: A method and a device for producing bipolar plates for fuel cells. A bipolar plate is formed by joining an anode plate to a cathode plate, wherein the anode plate and the cathode plate are formed by forming a substrate plate. In order to provide a cost-effective and automated method, it is proposed that a plate already provided with a reactive coating or catalyst coating, which is transported, automatically driven, via a transport device from the forming device to the joining device, is used as substrate plate.

Abstract: A method for separating blanks includes continuous conveying of a sheet metal strip in a transport direction to a laser cutting station, concurrent cutting of the sheet metal strip by at least one cutting laser, wherein a cut sheet metal strip is formed from successive sections of the same cutting geometry, transporting the cut sheet metal strip on a first conveyor belt in the transport direction, taking over the cut sheet metal strip from the first conveyor belt, transporting the cut sheet metal strip in the transport direction, separately ejecting the at least one residual blank of each section, transporting the at least one blank of each section into overlap with a second conveyor belt and ejecting the at least one blank from the suction conveyor, and transporting the blanks ejected one after the other from the suction conveyor horizontally in the transport direction to a collecting station.

Abstract: In a method for setting bending of at least one straightening roller in a roller straightening machine, the straightening roller is supported by a plurality of supporting roller devices arranged beside one another in the axial direction, wherein each supporting roller device can be adjusted by an actuating device such that stresses are produced in the straightening roller. To control the actuating device, a control system is provided, by which the adjustment of the supporting roller device can be set manually. Limiting values (vMA, vMI) with respect to the stresses produced in the straightening roller are stored in the control system. In the event of adjustment of one of the supporting roller devices, maxima (MA) and minima (MI) of the stresses produced in the straightening roller are calculated and it is checked whether the maxima (MA) and minima (MI) lie within the limiting values (vMA, vMI).

Abstract: Disclosed herein are systems and methods for monitoring performance of an ambulatory infusion pump. An ambulatory infusion pump can include a reservoir configured to contain a medicament including a plunger at a proximal end of the reservoir and an outlet port at a distal end of the reservoir. A motor can be configured to cause linear motion of a pushrod to contact and move the plunger to cause medicament to flow from the reservoir out of the outlet port to a patient. An optical encoder can be employed to monitor a linear position of the pushrod. In addition, the optical encoder can be employed to monitor additional system conditions and/or a secondary encoder can be employed to monitor the performance of the optical encoder.

Abstract: Disclosed herein are systems and methods for monitoring performance of an ambulatory infusion pump. An ambulatory infusion pump can include a reservoir configured to contain a medicament including a plunger at a proximal end of the reservoir and an outlet port at a distal end of the reservoir. A motor can be configured to cause linear motion of a pushrod to contact and move the plunger to cause medicament to flow from the reservoir out of the outlet port to a patient. An optical encoder can be employed to monitor a linear position of the pushrod. In addition, the optical encoder can be employed to monitor additional system conditions and/or a secondary encoder can be employed to monitor the performance of the optical encoder.

Abstract: A method and a device for producing bipolar plates for fuel cells. A bipolar plate is formed by joining an anode plate to a cathode plate, wherein the anode plate and the cathode plate are formed by forming a substrate plate. In order to provide a cost-effective and automated method, it is proposed that a plate already provided with a reactive coating or catalyst coating, which is transported, automatically driven, via a transport device from the forming device to the joining device, is used as substrate plate.

Abstract: A method and a device for producing bipolar plates for fuel cells. A bipolar plate is formed by joining an anode plate to a cathode plate, wherein the anode plate and the cathode plate are formed by forming a substrate plate. In order to provide a cost-effective and automated method, it is proposed that a plate already provided with a reactive coating or catalyst coating, which is transported, automatically driven, via a transport device from the forming device to the joining device, is used as substrate plate.

Abstract: A method of ligating DNA molecules, wherein the DNA molecules are in a hybrid with an RNA molecule, including the steps of providing DNA molecules that are in a RNA:DNA hybrid with an RNA molecule, and ligating the DNA molecules to each other with a double strand specific ligase

Abstract: The invention relates to a method for cutting a sheet metal blank from a sheet metal strip (1) continuously conveyed in a transport direction (T), by means of at least one laser cutting device (3), having the following steps: providing a laser cutting device (3) with at least one laser cutting head (5) which has a cutting nozzle (7) and which can be moved along a cutting path (S1, S2, S1?, S2?) specified so as to correspond to the geometry of the sheet metal blank by means of a controller (6), incrementally measuring the distance between the cutting nozzle (7) and the surface of the sheet metal strip (1) at at least one radially outer position (P1, P2) relative to the cutting nozzle (7) by means of a first distance measuring device (8), controlling the movement of the laser cutting head such that the first distance measuring device (8, 9) constantly remains overlapping the sheet metal strip (1), into a second position, in which the cutting nozzle is overlapping the sheet metal strip (1), wherein the height o

Abstract: A method of ligating DNA molecules, wherein the DNA molecules are in a hybrid with an RNA molecule, including the steps of providing DNA molecules that are in a RNA:DNA hybrid with an RNA molecule, and ligating the DNA molecules to each other with a double strand specific ligase.

Abstract: A method and a device for producing bipolar plates for fuel cells. A bipolar plate is formed by joining an anode plate to a cathode plate, wherein the anode plate and the cathode plate are formed by forming a substrate plate. In order to provide a cost-effective and automated method, it is proposed that a plate already provided with a reactive coating or catalyst coating, which is transported, automatically driven, via a transport device from the forming device to the joining device, is used as substrate plate.

Abstract: In a method for setting bending of at least one straightening roller in a roller straightening machine, the straightening roller is supported by a plurality of supporting roller devices arranged beside one another in the axial direction, wherein each supporting roller device can be adjusted by an actuating device such that stresses are produced in the straightening roller. To control the actuating device, a control system is provided, by which the adjustment of the supporting roller device can be set manually. Limiting values (vMA, vMI) with respect to the stresses produced in the straightening roller are stored in the control system. In the event of adjustment of one of the supporting roller devices, maxima (MA) and minima (MI) of the stresses produced in the straightening roller are calculated and it is checked whether the maxima (MA) and minima (MI) lie within the limiting values (vMA, vMI).

Abstract: A device for cutting sheet metal plates out of a sheet metal strip includes a laser cutting device moving back and forth in a transport direction of the sheet metal strip and a y-direction running perpendicular to the transport direction, a first conveyor belt having first end moving back and forth together with the laser cutting device in the transport direction, a second conveyor belt having a second end opposite the first end and moving back and forth in the transport direction. The first and second ends are moved such that a laser beam generated by the laser cutting device is directed towards a gap formed between the first and second ends and extending in the y-direction. In order to avoid adhesions to an underside of the sheet metal strip, at least one support strip and/or the dust discharge shaft is provided with a ventilation device for ventilating the gap.

Abstract: An apparatus for cutting metal plates out of a metal strip includes a laser cutting apparatus that is movable back and forth in a transport direction of the metal strip, and a support device for supporting the metal strip to be cut. The support device includes a first support device having a first support strip and a second support device having a second support strip located opposite the first support strip, wherein the first and the second support strip are moved concurrently with the laser cutting apparatus such that a laser beam of the laser cutting apparatus is always oriented towards a gap formed between the first and the second support strip. A dust discharging device is arranged downstream of the support strips in a discharging direction directed away from the laser cutting apparatus. The support strip and/or the dust discharge shaft includes a ventilation device for ventilating the gap.

Abstract: The present invention relates to methods for generating an amplified nucleic acid portion of a template nucleic acid, comprising obtaining said template nucleic acid, annealing at least one oligonucleotide primer to said template nucleic acid, annealing at least one oligonucleotide stopper to said template nucleic acid, elongating the at least one oligonucleotide primer in a template specific manner until the elongating product nucleic acid reaches the position of an annealed oligonucleotide stopper, whereby the elongation reaction is stopped, wherein in said elongation reaction said oligonucleotide stopper is not elongated, and wherein the elongated product nucleic acid is ligated to the 3? end of said oligonucleotide stopper—said stopper may also be a primer itself and uses and kits for performing said method.

Abstract: The invention relates to a method for correcting a predetermined cutting path for cutting a metal blank from a metal strip continuously transported in a transport direction x with the following steps: Simultaneously determining a first x coordinate x1 and a first y coordinate y1 of a point on a surface of the metal strip with respect to an x and a y reference; Determining a second coordinate y2 of the point with respect to the y reference at precisely the time when the metal strip has been moved in the transport direction x by a predetermined first distance dx1 with respect to the first x coordinate x1; Determining a first y correction value Ky1 by taking the difference between the first y coordinate y1 and the second y coordinate y2; and Using the first y correction value Ky1 to correct the cutting path coordinates describing the predetermined cutting path.