Patents by Inventor Alexander Sevy
Alexander Sevy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240092905Abstract: The present disclosure relates to systems for the expression of antibodies or antigen binding fragments in a subject, as well as methods of treatments of diseases therewith.Type: ApplicationFiled: April 19, 2023Publication date: March 21, 2024Inventors: Alexander SEVY, Brian ABEL, Hong JIANG, Arun RATURI, Thornton THOMPSON, John LEWIS, Ping WEE
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Publication number: 20230257803Abstract: Disclosed herein, inter alia, are novel strand-displacing polymerases and methods of use thereof.Type: ApplicationFiled: December 21, 2022Publication date: August 17, 2023Inventors: Souad NAJI, Eli N. GLEZER, Bruna Krebs KUTCHE, Ali NIKOOMANZAR, Alexander SEVY, Caleb NEWMAN, Ryan SHULTZABERGER, Abrehet ABDU, Youngjin CHO, Janell J. KOSMATKA
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Publication number: 20230203578Abstract: Disclosed herein, inter alia, are methods, enzymes, and compositions useful for nucleic acid sequencing.Type: ApplicationFiled: December 21, 2022Publication date: June 29, 2023Inventors: Souad NAJI, Eli N. GLEZER, Bruna Krebs KUTCHE, Ali NIKOOMANZAR, Alexander SEVY, Caleb NEWMAN, Ryan SHULTZABERGER, Abrehet ABDU, Youngjin CHO, Janell J. KOSMATKA
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Patent number: 10231820Abstract: Methods and materials for making complex, living, vascularized tissues for organ and tissue replacement, especially complex and/or thick, structures, such as liver tissue is provided. Tissue lamina is made in a system comprising an apparatus having (a) a first mold or polymer scaffold, a semi-permeable membrane, and a second mold or polymer scaffold, wherein the semi-permeable membrane is disposed between the first and second molds or polymer scaffolds, wherein the first and second molds or polymer scaffolds have means defining microchannels positioned toward the semi-permeable membrane, wherein the first and second molds or polymer scaffolds are fastened together; and (b) animal cells. Methods for producing complex, three-dimensional tissues or organs from tissue lamina are also provided.Type: GrantFiled: November 17, 2016Date of Patent: March 19, 2019Assignees: The Charles Stark Draper Laboratory, Inc., The General Hospital CorporationInventors: Joseph P. Vacanti, Young-Moon M. Shin, Jennifer Ogilvie, Alexander Sevy, Tomoyuki Maemura, Osamu Ishii, Mohammad R. Kaazempur-Mofrad, Jeffrey T. Borenstein, Kevin R. King, Chiao-Chun Wang, Eli Weinberg
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Publication number: 20170296322Abstract: Methods and materials for making complex, living, vascularized tissues for organ and tissue replacement, especially complex and/or thick, structures, such as liver tissue is provided. Tissue lamina is made in a system comprising an apparatus having (a) a first mold or polymer scaffold, a semi-permeable membrane, and a second mold or polymer scaffold, wherein the semi-permeable membrane is disposed between the first and second molds or polymer scaffolds, wherein the first and second molds or polymer scaffolds have means defining microchannels positioned toward the semi-permeable membrane, wherein the first and second molds or polymer scaffolds are fastened together; and (b) animal cells. Methods for producing complex, three-dimensional tissues or organs from tissue lamina are also provided.Type: ApplicationFiled: November 17, 2016Publication date: October 19, 2017Inventors: Joseph P. Vacanti, Young-Moon M. Shin, Jennifer Ogilvie, Alexander Sevy, Tomoyuki Maemura, Osamu Ishii, Mohammad R. Kaazempur-Mofrad, Jeffrey T. Borenstein, Kevin R. King, Chiao-Chun Wang, Eli Weinberg
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Patent number: 9738860Abstract: Methods and materials for making complex, living, vascularized tissues for organ and tissue replacement, especially complex and/or thick, structures, such as liver tissue is provided. Tissue lamina is made in a system comprising an apparatus having (a) a first mold or polymer scaffold, a semi-permeable membrane, and a second mold or polymer scaffold, wherein the semi-permeable membrane is disposed between the first and second molds or polymer scaffolds, wherein the first and second molds or polymer scaffolds have means defining microchannels positioned toward the semi-permeable membrane, wherein the first and second molds or polymer scaffolds are fastened together; and (b) animal cells. Methods for producing complex, three-dimensional tissues or organs from tissue lamina are also provided.Type: GrantFiled: January 13, 2014Date of Patent: August 22, 2017Assignees: The General Hospital Corporation, The Charles Stark Draper Laboratory, Inc.Inventors: Joseph P. Vacanti, Young-Moon M. Shin, Jennifer Ogilvie, Alexander Sevy, Tomoyuki Maemura, Osamu Ishii, Mohammad R. Kaazempur-Mofrad, Jeffrey T. Borenstein, Kevin R. King, Chiao-Chun Wang, Eli Weinberg
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Publication number: 20140234953Abstract: Methods and materials for making complex, living, vascularized tissues for organ and tissue replacement, especially complex and/or thick, structures, such as liver tissue is provided. Tissue lamina is made in a system comprising an apparatus having (a) a first mold or polymer scaffold, a semi-permeable membrane, and a second mold or polymer scaffold, wherein the semi-permeable membrane is disposed between the first and second molds or polymer scaffolds, wherein the first and second molds or polymer scaffolds have means defining microchannels positioned toward the semi-permeable membrane, wherein the first and second molds or polymer scaffolds are fastened together; and (b) animal cells. Methods for producing complex, three-dimensional tissues or organs from tissue lamina are also provided.Type: ApplicationFiled: January 13, 2014Publication date: August 21, 2014Applicants: THE GENERAL HOSPITAL CORPORATION, THE CHARLES STARK DRAPER LABORATORYInventors: Joseph P. Vacanti, Young-Moon M. Shin, Jennifer Ogilvie, Alexander Sevy, Tomoyuki Maemura, Osamu Ishii, Mohammad R. Kaazempur-Mofrad, Jeffrey T. Borenstein, Kevin R. King, Chiao-Chun Wang, Eli Weinberg
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Patent number: 8642336Abstract: Methods and materials for making complex, living, vascularized tissues for organ and tissue replacement, especially complex and/or thick structures, such as liver tissue is provided. Tissue lamina is made in a system comprising an apparatus having (a) a first mold or polymer scaffold, a semi-permeable membrane, and a second mold or polymer scaffold, wherein the semi-permeable membrane is disposed between the first and second molds or polymer scaffolds, wherein the first and second molds or polymer scaffolds have means defining microchannels positioned toward the semi-permeable membrane, wherein the first and second molds or polymer scaffolds are fastened together; and (b) animal cells. Methods for producing complex, three-dimensional tissues or organs from tissue lamina are also provided.Type: GrantFiled: May 24, 2010Date of Patent: February 4, 2014Assignees: The General Hospital Corporation, The Charles Stark Draper LaboratoryInventors: Joseph P. Vacanti, Young-Moon Michael Shin, Jennifer Ogilvie, Alexander Sevy, Tomoyuki Maemura, Osamu Ishii, Mohammad Reza Kaazempur-Mofrad, Jeffrey T. Borenstein, Kevin R. King, Chiao-Chun Wang, Eli Weinberg
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Publication number: 20100267136Abstract: Methods and materials for making complex, living, vascularized tissues for organ and tissue replacement, especially complex and/or thick structures, such as liver tissue is provided. Tissue lamina is made in a system comprising an apparatus having (a) a first mold or polymer scaffold, a semi-permeable membrane, and a second mold or polymer scaffold, wherein the semi-permeable membrane is disposed between the first and second molds or polymer scaffolds, wherein the first and second molds or polymer scaffolds have means defining microchannels positioned toward the semi-permeable membrane, wherein the first and second molds or polymer scaffolds are fastened together; and (b) animal cells. Methods for producing complex, three-dimensional tissues or organs from tissue lamina are also provided.Type: ApplicationFiled: May 24, 2010Publication date: October 21, 2010Applicants: THE GENERAL HOSPITAL CORPORATION, THE CHARLES STARK DRAPER LABORATORYInventors: Joseph P. Vacanti, Young-Moon Michael Shin, Jennifer Ogilvie, Alexander Sevy, Tomoyuki Maemura, Osamu Ishii, Mohammad Reza Kaazempur-Mofrad, Jeffrey T. Borenstein, Kevin R. King, Chiao-Chun Wang, Eli Weinberg
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Patent number: 7759113Abstract: Methods and materials for making complex, living, vascularized tissues for organ and tissue replacement, especially complex and/or thick structures, such as liver tissue is provided. Tissue lamina is made in a system comprising an apparatus having (a) a first mold or polymer scaffold, a semi-permeable membrane, and a second mold or polymer scaffold, wherein the semi-permeable membrane is disposed between the first and second molds or polymer scaffolds, wherein the first and second molds or polymer scaffolds have means defining microchannels positioned toward the semi-permeable membrane, wherein the first and second molds or polymer scaffolds are fastened together; and (b) animal cells. Methods for producing complex, three-dimensional tissues or organs from tissue lamina are also provided.Type: GrantFiled: June 28, 2002Date of Patent: July 20, 2010Assignees: The General Hospital Corporation, The Charles Stark Draper LaboratoryInventors: Joseph P. Vacanti, Young-Moon Michael Shin, Jennifer Ogilvie, Alexander Sevy, Tomoyuki Maemura, Osamu Ishii, Mohammad Reza Kaazempur-Mofrad, Jeffrey T. Borenstein, Kevin R. King, Chiao-Chun Wang, Eli Weinberg
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Publication number: 20100098742Abstract: Methods and materials for making complex, living, vascularized tissues for organ and tissue replacement, especially complex and/or thick structures, such as liver tissue is provided. Tissue lamina is made in a system comprising an apparatus having (a) a first mold or polymer scaffold, a semi-permeable membrane, and a second mold or polymer scaffold, wherein the semi-permeable membrane is disposed between the first and second molds or polymer scaffolds, wherein the first and second molds or polymer scaffolds have means defining microchannels positioned toward the semi-permeable membrane, wherein the first and second molds or polymer scaffolds are fastened together; and (b) animal cells. Methods for producing complex, three-dimensional tissues or organs from tissue lamina are also provided.Type: ApplicationFiled: June 28, 2002Publication date: April 22, 2010Inventors: Joseph P. Vacanti, Young-Moon Michael Shin, Jennifer Ogilvie, Alexander Sevy, Tomoyuki Maemura, Osamu Ishii, Mohammad Reza Kaazempur-Mofrad, Jeffrey T. Borenstein, Kevin R. King, Chiao-Chun Wang, Eli Weinberg