Patents by Inventor Alexander Sibley

Alexander Sibley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of predicting responsiveness of a cancer to a VEGF targeting agent and methods of prognosing and treating cancer
    Patent number: 11499973
    Abstract: Methods of predicting responsiveness of a cancer in a subject to a cancer therapy including a VEGF targeting agent are provided. The methods may include obtaining a sample from the subject, determining an expression level of at least one biomarker selected from the group consisting of VEGF-D and PlGF in a sample from the subject, comparing the expression level of the biomarker in the sample to a reference level of the biomarker, and predicting the responsiveness of the cancer to treatment with the cancer therapy including a VEGF targeting agent. Optionally, the methods may further include administering a VEGF target agent and/or an anticancer or chemotherapy agent to the subject. Additional methods of prognosing and treating a cancer in a subject are also provided.
    Type: Grant
    Filed: May 17, 2017
    Date of Patent: November 15, 2022
    Assignee: Duke University
    Inventors: Andrew Nixon, Chris Brady, Yingmiao Liu, Herbert Hurwitz, Kouros Owzar, Alexander Sibley, Chen Jiang, Ace Hatch, Mark Starr
  • Methods of Predicting Responsiveness of a Cancer to a VEGF Targeting Agent and Methods of Prognosing and Treating Cancer
    Publication number: 20190204320
    Abstract: Methods of predicting responsiveness of a cancer in a subject to a cancer therapy including a VEGF targeting agent are provided. The methods may include obtaining a sample from the subject, determining an expression level of at least one biomarker selected from the group consisting of VEGF-D and PlGF in a sample from the subject, comparing the expression level of the biomarker in the sample to a reference level of the biomarker, and predicting the responsiveness of the cancer to treatment with the cancer therapy including a VEGF targeting agent. Optionally, the methods may further include administering a VEGF target agent and/or an anticancer or chemotherapy agent to the subject. Additional methods of prognosing and treating a cancer in a subject are also provided.
    Type: Application
    Filed: May 17, 2017
    Publication date: July 4, 2019
    Applicant: Duke University
    Inventors: Andrew Nixon, Chris Brady, Yingmiao Liu, Herbert Hurwitz, Kouros Owzar, Alexander Sibley, Chen Jiang, Ace Hatch, Mark Starr