Abstract: Improved methods of producing nucleic acid molecules, proteins and peptides in host cells and genetically engineered plants, vectors and constructs therefor.

Abstract: Methods, reagents and compositions for providing more accurate and reliable genetic modification are provided. In particular, a nucleic acid encoding a fusion protein comprising a 5? to 3? DNA exonuclease domain and an RNA binding domain is described. Also provided are methods, reagents and compositions for in vivo genetic modification of the genome of a human or animal cell. Furthermore, the present application relates to uses of the said methods, reagents and compositions in the treatment of disease and production of transgenic animals.

Abstract: Systems and methods of dynamic optimization for data quality control in crowd sourcing tasks to crowd labor are disclosed. In one aspect, embodiments of the present disclosure include a method, which may be implemented on a system, for dynamically monitoring results received from workers for a task distributed for evaluation via a job distribution platform, incrementally assigning additional workers to the task using the results and continuously monitoring additional results to assign any additional workers if needed to meet a quality metric for the task.

Abstract: Methods, reagents and compositions for providing more accurate and reliable genetic modification are provided. In particular a nucleic acid encoding a fusion protein comprising an endonuclease domain and a binding domain for an origin of replication is described. Also provided are methods, reagents and compositions for in vivo genetic modification of the genome of a non-animal cell or organism. Furthermore, the present application relates to uses of the said methods, reagents and compositions for introducing desirable traits to non-animal organisms or ameliorating or removing non-desirable traits in these organisms including in the treatment of disease.

Abstract: Systems and methods of a job distribution platform for aggregating performance data in a worker profile for workers in performing crowd sourced tasks are disclosed. In one aspect, embodiments of the present disclosure include a method, which may be implemented on a system, of generating and storing performance data when a worker performs one or more tasks distributed online to their respective computing devices by a job distribution platform which crowd sources tasks over a network to remote workers. The tasks can span current jobs and a history of previous jobs distributed to the worker and the job performance data for the worker is collected for current and previous jobs. New jobs can be assigned to a worker selected based on performance data of the worker. Other types of worker information may also be tracked and generated for multiple workers in various worker pools (channels), for example, psych questions or other more subjective data collected from a worker or contributor in addition to performance.

Abstract: An isolated polynucleotide sequence that encodes for a multi domain recombination protein, comprising a donor DNA-Binding domain (BDB); and a chromosomal binding domain (CBD). A plant cell can be transformed by introducing into the cell a first nucleic acid sequence, which comprises a plant nuclear promoter operably linked to a first nucleic acid sequence comprising the stated polynucleotide sequence, and a second nucleic acid sequence, which comprises a donor nucleic acid sequence and at least two flanking sequences capable of binding to a donor binding domain of the protein, the sequences being located adjacent to each end of the donor polynucleotide sequence forming left and right borders thereto.

Abstract: An isolated polynucleotide sequence that encodes for a multi domain recombination protein, comprising a donor DNA-Binding domain (BDB); and a chromosomal binding domain (CBD). A plant cell can be transformed by introducing into the cell a first nucleic acid sequence, which comprises a plant nuclear promoter operably linked to a first nucleic acid sequence comprising the stated polynucleotide sequence, and a second nucleic acid sequence, which comprises a donor nucleic acid sequence and at least two flanking sequences capable of binding to a donor binding domain of the protein, the sequences being located adjacent to each end of the donor polynucleotide sequence forming left and right borders thereto.

Abstract: Improved methods of producing nucleic acid molecules, proteins and peptides in host cells and genetically engineered plants, vectors and constructs therefor.

Abstract: Method for heterologous protein production in plant cell plastids comprising introducing into plant cells nucleic acid components that encode heterologous proteins under the control of promoters operative in plastids, vectors, host cells, plants and uses thereof.

Abstract: Method for heterologous RNA species and protein production in plant cell mitochondria comprising introducing into plant cells nucleic acid components that encode heterologous proteins/RNAS under the control of promoters operative in mitochondria, vectors, host cells, plants and uses thereof.

Abstract: Method for heterologous protein production in plant cell plastids comprising introducing into plant cells nucleic acid components that encode heterologous proteins under the control of promoters operative in plastids, vectors, host cells, plants and uses thereof.

Abstract: Method for heterologous protein production in plant cell plastids comprising introducing into plant cells nucleic acid components that encode heterologous proteins under the control of promoters operative in plastids, vectors, host cells, plants and uses thereof.

Abstract: The present invention relates to the use of catalysts of general formula (I): (L1)M1-X-M2(L2)??(I) wherein: M1 and M2, either identical or different, represent metal atoms; X represents a nitrogen atom; L1 and L2, either identical or different are coordinated with M1 and M2, respectively, and represent ligands of the tetradentate type, for catalytic oxidation of halogenated compounds.

Abstract: Systems and methods of a job distribution platform for aggregating performance data in a worker profile for workers in performing crowd sourced tasks are disclosed. In one aspect, embodiments of the present disclosure include a method, which may be implemented on a system, of generating and storing performance data when a worker performs one or more tasks distributed online to their respective computing devices by a job distribution platform which crowd sources tasks over a network to remote workers. The tasks can span current jobs and a history of previous jobs distributed to the worker and the job performance data for the worker is collected for current and previous jobs. New jobs can be assigned to a worker selected based on performance data of the worker. Other types of worker information may also be tracked and generated for multiple workers in various worker pools (channels), for example, psych questions or other more subjective data collected from a worker or contributor in addition to performance.

Abstract: Systems and methods for evaluating a worker in performing crowd sourced tasks and providing in-task training are disclosed. In one aspect, embodiments of the present disclosure include a method, which may be implemented on a system, for selecting a job distributed through a job distribution platform for workers to work on, for use to generate a test task, the job being associated with a known correct result, associating a manipulated result, known to be an incorrect result for the job, with the job to generate the test task, and/or presenting the job with the manipulated result as the test task to a worker for evaluation of work quality of the worker. The job distribution platform crowd sources tasks online to workers to work on via their respective computing devices.

Abstract: Systems and methods for evaluating a worker in performing crowd sourced tasks and providing in-task training are disclosed. In one aspect, embodiments of the present disclosure include a method, which may be implemented on a system, for selecting a job distributed through a job distribution platform for workers to work on, for use to generate a test task, the job being associated with a known correct result, associating a manipulated result, known to be an incorrect result for the job, with the job to generate the test task, and/or presenting the job with the manipulated result as the test task to a worker for evaluation of work quality of the worker. The job distribution platform crowd sources tasks online to workers to work on via their respective computing devices.

Abstract: The present invention relates to the use of catalysts of general formula (I): (L1)M1-X-M2(L2) ??(I) wherein: M1 and M2, either identical or different, represent metal atoms; X represents a nitrogen atom; L1 and L2, either identical or different are coordinated with M1 and M2, respectively, and represent ligands of the tetradentate type, for catalytic oxidation of halogenated compounds.

Abstract: Systems and methods for evaluating a worker in performing crowd sourced tasks and providing in-task training are disclosed. In one aspect, embodiments of the present disclosure include a method, which may be implemented on a system, for selecting a job distributed through a job distribution platform for workers to work on, for use to generate a test task, the job being associated with a known correct result, associating a manipulated result, known to be an incorrect result for the job, with the job to generate the test task, and/or presenting the job with the manipulated result as the test task to a worker for evaluation of work quality of the worker. The job distribution platform crowd sources tasks online to workers to work on via their respective computing devices.

Abstract: Systems and methods of dynamic optimization for data quality control in crowd sourcing tasks to crowd labor are disclosed. In one aspect, embodiments of the present disclosure include a method, which may be implemented on a system, for dynamically monitoring results received from workers for a task distributed for evaluation via a job distribution platform, incrementally assigning additional workers to the task using the results and continuously monitoring additional results to assign any additional workers if needed to meet a quality metric for the task.

Abstract: A method and system tracks models and predict object movement in an environment. Sequences of temporally and spatially adjacent events sensed by the set of sensors are linked to form a set of tracklets. Each tracklet has an associated starting and terminating location. The tracklets are used to construct a directed graph including starting nodes, terminating nodes, and, intermediate nodes connected by edges. The intermediate nodes can be split nodes where tracklets diverge onto different tracks, and join nodes where multiple tracklets converge onto a single path. Probabilities are assigned to the edges to model and predict movement of the objects in the environment.